Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | mDia2 is a downstream effector of the Rho GTPases Rac1 and Rac2, Rac1 and Rac2 bind to mDia2 GBD in a GTP-dependent manner | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G12V | constitutively active Rac mutant | Mus musculus |
T17N | dominant negative Rac mutant | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NSC23766 | Rac-specific inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | Rac GTPases play an important role in enucleation of mammalian erythroblasts | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione-Sepharose 4B bead chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 5'-O-(3-thiotriphosphate) + H2O | - |
Mus musculus | guanosine 5'-O-diphosphate + thiophosphate | - |
? | |
additional information | Rac GTPases play an important role in enucleation of mammalian erythroblasts | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rac GTPase | - |
Mus musculus |
Rac1 | isoform | Mus musculus |
Rac2 | isoform | Mus musculus |