the enzyme is involved in nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Nuclear import of Ran relies on a small RanGTP-binding protein, nuclear transport factor 2
Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1. LIP1 plays a unique negative role in controlling circadian light input and is required for precise entrainment of the plant
Rac1 regulates gene expression, cell cycle progression and rearrangement of the actin cytoskeleton, Rac1 is ubiquitously expressed and regulates a wide variety of cellular processes
RhoA promotes actin-myosin contractility and, thereby, the formation of stress fibers and focal adhesions, regulating cell shape, attachment and motility
tuberous sclerosis complex TSC2 displays activity of a GTPase-activating protein specifically towards the small G protein Rheb and inhibits its ability to stimulate the mTOR signalling pathway
small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. Altering the intracellular trafficking of P-glycoprotein by modulation of its small GTPase regulators can be potential strategy to overcome multidrug resistance, a major obstacle in cancer chemotherapy
small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions
the small GTPase Rac plays a crucial role in activation of Nox2- and Nox1-based oxidases i all the possible combinations of the organizer p47phox or Noxo1 with the activator p67phox or Noxa1
small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions
Rho3p and Rho4p are involved in regulating cell polarity by controlling polarized exocytosis. It is proposed that Wsc1p participates in the regulation of a Rho3/4-dependent cellular mechanism
Campylobacter jejuni invade host target cells by a unique mechanism and the activation of the Rho GTPase members Rac1 and Cdc42 play a crucial role in this entry process
Rho1 activity is required for proper development of the circular visceral mesoderm upon which the gland migrates, Rho1 GTPase regulates salivary gland invagination by maintaining apical localization of Crumbs, Drosophila atypical protein kinase C and Stardust and that this occurs partially through regulation of Crumbs RNA level and apical localization of the transcript and by inducing apical constriction and cell shape change through Rho-kinase
Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization
RhoA activity is required for modulating cell migration and proliferation through cytoskeleton reorganization and focal adhesion formation in response to wounding
enzyme Rheb does not co-localize with microtubules but interacts with unpolymerized free alphabeta-tubulin, alphabeta-tubulin is a Rheb-binding protein. Rheb binds to deacetylated soluble alphabeta-tubulin
Knock down of Rab21 impairs integrin-mediated cell adhesion and motility, its overexpression stimulates cell migration and cancer cell adhesion to collagen and human bone
in 3T3-L1 adipocytes, stimulation of lipolysis increases the association of Rab18 with lipid droplets, suggesting that recruitment of Rab18 is regulated by the metabolic state of individual lipid droplets
Rab and Ral GTPases function in exocyst assembly and vesicle-tethering processes, whereas the Rho family of GTPases functions in the local activation of the exocyst complex to facilitate downstream vesicle-fusion events
Rac1 and Cdc42 are not required for differentiation and migration of neural crest cells, but are essential for mitotic activity and cell-cycle control in neural crest cell target structures
Rac1 is a central regulator of rapid encoding of novel spatial information in vivo, Rac1 mutants display deficits in working/episodic-like memory in the delayed matching-to-place
Rac2 selectively controls phagosomal alkalinization and antigen crosspresentation in CD8+ dendritic cells, Rac2 determines the subcellular assembly of the NADPH oxidase complex to phagosomes in CD8+ cells whereas in CD8- cells Rac1 mediates the assembly of NOX2 at the plasma membrane
Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization
Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
Ras-related, small GTPases act as molecular switches that control a variety of cellular processes by cycling between alternative conformational states: in the active state, they are bound with GTP, and in the inactive state, they are bound with GDP. In their active state, GTPases recognize their target effector proteins and evoke responses until GTP hydrolysis returns the switch to the off position
RhoA activity is required for modulating cell migration and proliferation through cytoskeleton reorganization and focal adhesion formation in response to wounding