3.6.5.2: small monomeric GTPase
This is an abbreviated version!
For detailed information about small monomeric GTPase, go to the full flat file.
Word Map on EC 3.6.5.2
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3.6.5.2
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actin
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oncogene
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cytoskeleton
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endosomes
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colorectal
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pancreatic
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metastasis
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endothelial
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adenocarcinoma
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gtp-bound
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tumorigenesis
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carcinogenesis
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endocytic
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integrins
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gdp
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gtpase-activating
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dominant-negative
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phosphatidylinositol
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mapk
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vesicular
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erk
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microtubule
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synaptic
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exocytosis
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filopodia
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cargo
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neurite
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traffic
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myosin
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3-kinase
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guanosine
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cell-cell
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protrusion
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cytokinesis
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ruffle
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proto-oncogene
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farnesylation
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prenylation
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geranylgeranylation
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rock
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adhesions
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lamellipodia
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adherens
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pleckstrin
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raf
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aminoacyl-trnas
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melanosomes
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farnesyltransferase
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rho-associated
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actomyosin
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analysis
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drug development
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pharmacology
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medicine
- 3.6.5.2
- actin
- oncogene
- cytoskeleton
- endosomes
- colorectal
- pancreatic
- metastasis
- endothelial
- adenocarcinoma
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gtp-bound
- tumorigenesis
- carcinogenesis
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endocytic
- integrins
- gdp
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gtpase-activating
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dominant-negative
- phosphatidylinositol
- mapk
- vesicular
- erk
- microtubule
- synaptic
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exocytosis
- filopodia
-
cargo
-
neurite
-
traffic
- myosin
- 3-kinase
- guanosine
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cell-cell
-
protrusion
-
cytokinesis
-
ruffle
- proto-oncogene
-
farnesylation
-
prenylation
-
geranylgeranylation
-
rock
-
adhesions
- lamellipodia
-
adherens
-
pleckstrin
- raf
- aminoacyl-trnas
- melanosomes
-
farnesyltransferase
-
rho-associated
- actomyosin
- analysis
- drug development
- pharmacology
- medicine
Reaction
Synonyms
ADP-ribosylation factor 6, ADP-ribosylation factor-like protein 2, Alp41, Alp41/Arl2, ARD1, Arf 1, Arf 1-6, Arf-like 3 small GTPase, Arf6, ARL2, Arl6, Arl6/BBS3, Arl9, AtRopGEF12, Cdc42, Cdc42Hs, Der, Der GTPase, double Era-like protein, EC 3.6.1.47, EF-Tu, EhRab11B, elF-2, EmRas, FgCdc42, FgRac1, FgRHO1, FgRHO2, FgRHO3, FgRHO4, GCC185, Gem, GhRac1 GTPase, Gsp1p, GTP-phosphohydrolase, GTPase, GTPase Alp41/Arl2, GTPase TcRho1, GTPase Toc33, GTPase Toc33/34, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, H-Ras, K-Ras, Kir, Krev-1, M-Ras, monomeric G protein, monomeric GTPase, More, non-canonical Ras-like G protein, OsRac1, p21 ras, Pc-Rac1, PfG, PRA, Pra2, Pra3, Rab GTPase, Rab GTPase protein 5, Rab11, Rab13, Rab15, Rab18, Rab1a, Rab1B, Rab21, Rab23, Rab27a, Rab27a GTPase, Rab27B, Rab2A, Rab2B, Rab30, Rab33A, Rab35, Rab36, Rab37, Rab38, Rab3A, Rab4a, Rab6A, Rab6B, Rab8, Rab8A, Rab9A, Rab9B, RabE, RabE1d, Rac, Rac GTPase, Rac-like GTP-binding protein 1, Rac1, Rac1 GTPase, Rac2, Rac3, Rac4, Rad, Rad GTPase, Ral GTPase, RalA, RalB, Ran, RAP, Rap GTPase, Rap1, Rap1 small GTPase, Rap1A, Rap1b, Rap2, Rap2 small GTPase, Rap2a, Rap2C, RAS, Ras GTPase, Ras homolog enriched in brain-like protein 1, Ras proximity 1, Ras related GTPase Rap, Ras-associated protein 1, Ras-like G-protein, Ras-like GTpase, Ras-related C3 botulinum toxin substrate 1, Ras-related protein rab-5, putative, Ras-related small GTPase, RAS1, RAS2, RasL10B, Rasl11a, Rem2, Rhb1, Rheb, Rheb GTPase, RHEBL1, Rho, Rho family small GTPase, Rho GTPase, RHO-1, Rho-GTPase, Rho-type GTPase, Rho-type small GTPase, Rho1, Rho1p, Rho3, Rho3p, RhoA, rhoA p21, RhoB, rhoB p20, RhoC, RhoGTPase, RhoH, ribosomal GTPase, ribosome-small-subunit-dependent GTPase A, RsgA, Ryh1, Ryh1 GTPase, Sar1, SdArf1, SdArf1-like, SdArf10, SdArf5, SdArf6, SdArl1, SdCdc42, SdK-Ras2, SdRab-like1, SdRab-like2, SdRab-like3, SdRab-like4, SdRab-like5, SdRab-like6, SdRab1-like, SdRab10, SdRab11, SdRab14, SdRab18, SdRab2, SdRab20-like, SdRab21, SdRab21-like, SdRab24, SdRab28, SdRab3, SdRab32, SdRab35, SdRab39, SdRab4, SdRab41/43, SdRab5, SdRab8, SdRac, SdRalA, SdRan, SdRap1, SdRap1-like, SdRheb, SdRho1, SdRho2, SdRho3, small G protein, small GTPase, small GTPase ARF6, small GTPase LIP1, small GTPase protein Rac-1, small GTPase Rab1, small GTPase Rab11b, small GTPase Rab2, small GTPase Rab21, small GTPase Rab27b, small GTPase Rac, small GTPase Rac-1, small GTPase Ral, small GTPase Ras, small GTPase Ras-related protein in brain 13, small GTPase Rho, small GTPase RhoA, small GTPase RhoV, small GTPase Rnd1, small GTPases Rab5, small GTPases Ral5, small nuclear GTPase Ran, small Rho GTPase, small Rho GTPase Rac1, small, monomeric G protein, small-GTPase, SmGTP, TbArl6, TcRABL4, vacuolar Rab GTPase, Wrch-1, YjeQ, Ypt1, Ypt1p, Ypt7, Ypt7p, YsxC
ECTree
3.6.5.2 small monomeric GTPaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.6.5.2 - small monomeric GTPase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
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human alveolar epithelial cell HAEC exposed to hypoxia, RhoA/ROCK activation is necessary for Na,K-ATPase endocytosis via a mechanism that requires mitochondrial reactive oxygen species
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tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb
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mRNA levels of RasL10B are down-regulated in all breast cancer cells tested (HBL100, MCF7, MDA-MB-468, MDA-MB-231 and MDA-MB-435. RasL10B) is a member of ras superfamily with tumor suppressor potential
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small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes
two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb
the enzyme is expressed in the R7 photoreceptor, localization study, overview
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GhRac1 is highly expressed during the elongation stage of fiber development with expression decreasing dramatically when the rate of the fiber elongation declines
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differential expression dynamics of small GTPases encoding genes during fruit development and ripening, overview
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important role for Rho-GTPases in the morphology and function of glomerular epithelial cells. Activation of RhoA appears to be protective against complement-mediated injury
lung cancer patients with metastasis and poor survival show low hRAB37 protein expression coinciding with low TIMP1 in tumours, hRAB37 is downregulated mainly by promoter hypermethylation in lung cancer cells and patients, low mRNA expression of hRAB37 gene is associated with tumour metastasis in lung cancer patients
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tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
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Rac1 activity serves as a regulator of cell senescence through modulation of cellular ROS, genomic stability, and p53 activity
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expression of Rap2C may be down-regulated diring the late phase of megakaryocyte differentiation and platelet formation
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small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression
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transient transcriptional upregulation of PpARF genes and of PpRAB genes of the A and D clades appears to coincide with peaks of growth speed and sugar accumulation and with the final phases of ripening
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a transient increase in Rac activity coupled with a transient decrease in RhoA activity occurs in honey bees with 4 days foraging experience compared with same-aged new foragers
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signal relay in which pollen receptor kinase AtPRK2a at the plasma membrane recruits AtRopGEF12 through its C terminus to maintain polar Rop activity in the pollen tube
adjacent, two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb, the abundance of the RASL11A transcript is diminished in prostate tumors in comparison to normal adjacent prostate tissue
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macrovascular lung pulmonary artery endothelial cell
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tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
smGTP gene displays low levels of expression prior to harvesting and increased 12 h after harvest. Low level of expression as the seed head emerges and shows a strong induction in late to post-anthesis tissues. Surprisingly very little expression is observed in seed heads at the milk and ripe seed head stages. A low level of smGTP expression is observed in stem and leaf tissue at this stage of development
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proliferation of dermal fibroblasts is crucial for the maintenance of skin. Rac1 activates proliferation of normal fibroblasts through stimulation of c-myc phosphorylation without affecting ERK1/2 activity
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Rac1 appears to be important for parenchyma expansion at the beginning of cytodifferentiation, while RhoC, Cdc42 and the inactive phosphorylated form of Rac1 seemed associated with lumen formation and cell polarization in terminal tubules in the developing submandilbular gland
Drosophila sp. (in: flies)
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conversion of plasma membrane topology during epithelial tube connection requires Arf-like 3 small GTPase
low content in late trophozoites, very low in early trophozoites
additional information
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in the adult mouse brain, Rab23 is detected in betaIII tubulin positive neuronal cell bodies and are most prominent in cortex, hypothalamus and the cerebellum
upon infection with Candida albicans, a significant increase in the mRNA level is observed
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prepared from tumor-bearing mice ex vivo. Tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
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RhoV mRNA is maternally expressed and accumulates shortly after gastrulation in the neural crest forming region. Rho functions in pathways that control neural crest cells specification
Rac2 is predominantly expressed in cells of the hematopoietic lineage
Rac2 is mainly present in the hematopoietic cells
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Vascular endothelial cadherin-mediated cell-cell adhesion is regulated by a Small GTPase, Rap1
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Ras is detected in glomerular cells, proximal convoluted tubule cells, distal convoluted tubule cells, cortical collecting tubule cells, medullar collecting duct cells, interstitial cells and subcapsular fibroblast. Ras plays a role in renal fibrosis
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Ras is detected in medullary endothelial cells, medullary interstitial cells, cortical interstitial cells and glomerular endothelial cells. Ras plays a role in renal fibrosis
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ARF6 is an essential component in the signaling pathway coupling hepatocyte growth factor signaling to hepatic cord formation
TLRs agonists induce changes in the expression of Rap2a in macrophages. In contrast to mRNA levels, Rap2a protein levels are increased after LPS treatments of macrophages
constitutively active RhoA in primary culture of spinal motoneurons
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hippocampal neuron. Rnd1 plays a critical role in neuronal activity-dependent dendritic development in hippocampal neurons. Overexpression of Rnd1 promotes dendritic growth and branching in cultured hippocampal neurons. Suppression of endogenous Rnd1 expression by RNA interference significantly inhibits neuronal activity-dependent dendritic development
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Rap1 and Rap2 share the ability to suppress synaptic transmission by inhibiting surface expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors containing the glutamate receptor alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor subunit GluR2. Rap1 and Rap2 have overlapping but distinct actions that potentially link the inhibition of synaptic transmission with the retraction of axons and dendrites. Rap2 in particular induced the retraction of axons and dendrites and the loss of spines and excitatory synapses, in a cell type-specific and activity-regulated fashion
Rap1b is the predominant Rap1 isoform expressed in neutrophils
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Rho-mediated signaling in osteoblasts seems to introduce major biases to bone resorption
uninfected normal cells have considerable levels of Cdc42, upon infection with Candida albicans and a significant increase in the mRNA level
uninfected normal cells have negligible quantities of mRNA for Rac1, upon infection with Candida albicans a significant increase in the mRNA level is observed
uninfected normal cells have negligible quantities of mRNA for RhoA, upon infection with Candida albicans a significant increase in the mRNA level is observed
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Rad GTPase is overexpressed in skeletal muscle of humans with type II diabetes
RhoH is expressed strongest in T-lymphocytes and acts as a positive regulatory factor for thymocyte selection and T-cell receptor signalling
RhoH is expressed strongest in T-lymphocytes and acts as a positive regulatory factor for thymocyte selection and T-cell receptor signalling
two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb
additional information
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mutant Rab27a is isolated from patients with Griscelli syndrome type 2
additional information
the RASL11A transcript is ubiquitously expressed in human tissues, no expression in thymus and leukocytes
additional information
the RASL11A transcript is ubiquitously expressed in human tissues, no expression in thymus and leukocytes
additional information
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the RASL11A transcript is ubiquitously expressed in human tissues, no expression in thymus and leukocytes
additional information
RhoH is underexpressed in hairy cell leukaemia and acute myeloid leukaemia cells
additional information
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RhoH is underexpressed in hairy cell leukaemia and acute myeloid leukaemia cells
additional information
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the enzyme expression is frequently lost in lung adenocarcinoma cells
additional information
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Rab23 is absent from glial fibrillary acidic protein positive astrocytes or CNPase positive oligodendrocytes
additional information
Rap1b is expressed in all tissues, including endothelial cells
additional information
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Rap1b is expressed in all tissues, including endothelial cells
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additional information
transcript levels and expression of the enzyme are significantly increased in the erythrocytic phase in particular during schizont and gametocyte formation
additional information
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transcript levels and expression of the enzyme are significantly increased in the erythrocytic phase in particular during schizont and gametocyte formation
additional information
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Pc-Rac1 is expressed in all examined tissues with the highest expression level in hemocytes
