Literature summary for 3.6.5.2 extracted from

Fu, Z.; Lee, S.H.; Simonetta, A.; Hansen, J.; Sheng, M.; Pak, D.T.
Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons (2007), J. Neurochem., 100, 118-131.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	Rap1 and Rap2 share the ability to suppress synaptic transmission by inhibiting surface expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors containing the glutamate receptor alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor subunit GluR2. Rap1 and Rap2 have overlapping but distinct actions that potentially link the inhibition of synaptic transmission with the retraction of axons and dendrites. Rap2 in particular induced the retraction of axons and dendrites and the loss of spines and excitatory synapses, in a cell type-specific and activity-regulated fashion	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
Rap1 small GTPase	-	Rattus norvegicus
Rap2 small GTPase	-	Rattus norvegicus

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Release 2023.1 (January 2023)