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Literature summary for 3.6.5.2 extracted from

  • Quilliam, L.A.; Der, C.J.; Clark, R.; O'Rourke, E.C.; Zhang, K.; McCormick, F.; Bokoch, G.M.
    Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins (1990), Mol. Cell. Biol., 10, 2901-2908.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
GTPase activating protein GAP Rap-GAP in neutrophil cytosol, increased rate of GTP hydrolysis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
T35A Rap1A, blocks abilitiy of Rap-GAP to stimulate GTP hydrolysis Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ in absence of Mg2+ rapid release of GDP but dissociation rate of GTP very slow Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens
-
GDP + phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Homo sapiens GDP + phosphate
-
ir

Synonyms

Synonyms Comment Organism
Krev-1
-
Homo sapiens
Rap1A
-
Homo sapiens