Reference on EC 3.6.5.2 - small monomeric GTPase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sauvage, C.; Rumigny, J.F.; Maitre, M.
Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation
Mol. Cell. Biochem.
107
65-77
1991
Homo sapiens
Finlin, B.S.; Shao, H.; Kadono-Okuda, K.; Guo, N.; Andres, D.A.
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
Biochem. J.
347
223-231
2000
Rattus sp.
Albert, S.; Will, E.; Gallwitz, D.
Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases
EMBO J.
18
5216-5225
1999
Saccharomyces cerevisiae
Seastone, D.J.; Zhang, L.; Buczynski, G.; Rebstein, P.; Weeks, G.; Spiegelman, G.; Cardelli, J.
The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum
Mol. Biol. Cell
10
393-406
1999
Dictyostelium discoideum
Haberland, J.; Gerke, V.
Conserved charged residues in the leucin-rich repeat domain of the Ran GTPase activating protein are required for Ran binding and GTPase activation
Biochem. J.
343
653-662
1999
Saccharomyces cerevisiae, Homo sapiens
Illenberger, D.; Schwald, F.; Pimmer, D.; Binder, W.; Maier, G.; Dietrich, A.; Gierschik, P.
Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1
EMBO J.
17
6241-6249
1998
Bos taurus, Homo sapiens
Stochaj, U.; Hejazi, M.; Belhumeur, P.
The small GTPase Gsp1p binds to the repeat domain of the nucleoporin Nsp1p
Biochem. J.
330
421-427
1998
Saccharomyces cerevisiae
Gamblin S.J.; Smerdon, S.J.
GTPase-activating proteins and their complexes
Curr. Opin. Struct. Biol.
8
195-201
1998
Homo sapiens
Hall, A.
Rho GTPases and the actin cytoskeleton
Science
279
509-514
1998
Saccharomyces cerevisiae, Homo sapiens
Dumas, J.J.; Zhu, Z.; Conolly, J.L.; Lambright, D.G.
Structural basis of activation and GTP hydrolysis in Rab proteins
Structure
7
413-423
1999
Rattus sp.
Vitale, N.; Moss, J.; Vaughan, M.
Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1)
J. Biol. Chem.
273
2553-2560
1998
Homo sapiens
Rittinger, K.; Walker, P.A.; Eccleston, J.F.; Smerdon, S.J.; Gamblin, S.J.
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue
Nature
389
758-762
1997
Homo sapiens
Saitoh, H.; Cooke, C.A.; Burgess, W.H.; Earnshaw, W.C.; Dasso, M.
Direct and indirect association of the small GTPase Ran with nuclear pore proteins and soluble transport factors: Studies in Xenopus laevis egg extracts
Mol. Biol. Cell
7
1319-1334
1996
Xenopus laevis
Polakis, P.G.; Rubinfeld, B.; Evans, T.; McCormick, F.
Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krec-1 from HL60 cells
Proc. Natl. Acad. Sci. USA
88
239-243
1991
Homo sapiens
Kim, J.H.; Cho, Y.S.; Kim, B.C.; Kim, Y.S.; Lee, G.S.
Role of Rho GTPase in the endothelin-1-induced nuclear signaling
Biochem. Biophys. Res. Commun.
232
223-226
1997
Rattus sp.
Janoueix-Lerosey, I.; Polakis, P.; Tavitian, A.; de Gunzburg, J.
Regulation of the GTPase activity of the Ras-related Rap2 protein
Biochem. Biophys. Res. Commun.
189
455-464
1992
Homo sapiens
Fukui, K.; Sasaki, T.; Imazumi, K.; Matsuura, Y.; Nakanishi, H.; Takai, Y.
Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins
J. Biol. Chem.
272
4655-4658
1997
Rattus sp.
Geyer, M.; Wittinghofer, A.
GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding protein
Curr. Opin. Struct. Biol.
7
786-792
1997
Bos taurus, Homo sapiens, Rattus sp.
Fischer, R.; Wei, Y.; Anagli, J.; Berchtold, M.W.
Calmodulin binds to and inhibits GTP binding of the Ras-like GTPase Kir/Gem
J. Biol. Chem.
271
25067-25070
1996
Homo sapiens
Li, R.; Zhang, B.; Zheng, Y.
Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain p190
J. Biol. Chem.
272
32830-32835
1997
Homo sapiens
Jones, S.; Litt, R. J.; Richardson, C.J.; Segev, N.
Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport
J. Cell Biol.
130
1051-1061
1995
Saccharomyces cerevisiae, Homo sapiens
Quilliam, L.A.; Der, C.J.; Clark, R.; O'Rourke, E.C.; Zhang, K.; McCormick, F.; Bokoch, G.M.
Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins
Mol. Cell. Biol.
10
2901-2908
1990
Homo sapiens
Ueda, T.; Kikuchi, A.; Ohga, N.; Yamamoto, J.; Takai, Y.
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein
J. Biol. Chem.
265
9373-9380
1990
Bos taurus
Yamamoto, J.; Kikuchi, A.; Ueda, T.; Ohga, N.; Takai, Y.
A GTPase-activating protein for rhoB p20, a ras p21-like GTP-binding protein - partial purification, characterization and subcellular distribution in rat brain
Mol. Brain Res.
8
105-111
1990
Bos taurus, Rattus sp.
Moran, M.F.; Polakis, P.; McCormick, F.; Pawson, T.; Ellis, C.
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein
Mol. Cell. Biol.
11
1804-1812
1991
Rattus sp.
Bourne, H.R.; Sanders, D.A.; McCormick, F.
The GTPase superfamily: conserved structure and molecular mechanism
Nature
349
117-127
1991
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Escherichia coli EF-Tu
Hall, A.
Small GTP-binding proteins and the regulation of the actin cytoskeleton
Annu. Rev. Cell Biol.
10
31-54
1994
Aplysia sp., Mammalia
Donaldson, J.G.; Jackson, C.L.
Regulators and effectors of the ARF GTPases
Curr. Opin. Cell Biol.
12
475-482
2000
Saccharomyces cerevisiae
Zhao, J.; Wang, W.N.; Tan, Y.C.; Zheng, Y.; Wang, Z.X.
Effect of Mg2+ on the kinetics of guanine nucleotide binding and hydrolysis by Cdc42
Biochem. Biophys. Res. Commun.
297
653-658
2002
Homo sapiens
Louro, R.; Nakaya, H.I.; Paquola, A.C.; Martins, E.A.; da Silva, A.M.; Verjovski-Almeida, S.; Reis, E.M.
RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors
Biochem. Biophys. Res. Commun.
316
618-627
2004
Homo sapiens (Q6T310), Homo sapiens (Q6T311), Homo sapiens
Menasche, G.; Feldmann, J.; Houdusse, A.; Desaymard, C.; Fischer, A.; Goud, B.; de Saint Basile, G.
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients
Blood
101
2736-2742
2003
Homo sapiens
Haeusler, L.C.; Blumenstein, L.; Stege, P.; Dvorsky, R.; Ahmadian, M.R.
Comparative functional analysis of the Rac GTPases
FEBS Lett.
555
556-560
2003
Homo sapiens, Homo sapiens (P60763)
Inaba, T.; Nagano, Y.; Nagasaki, T.; Sasaki, Y.
Distinct localization of two closely related Ypt3/Rab11 proteins on the trafficking pathway in higher plants
J. Biol. Chem.
277
9183-9188
2002
Pisum sativum
Wennerberg, K.; Der, C.J.
Rho-family GTPases: It's not only Rac and Rho (and I like it)
J. Cell Sci.
117
1301-1312
2004
Homo sapiens
Simpson, J.C.; Griffiths, G.; Wessling-Resnick, M.; Fransen, J.A.; Bennett, H.; Jones, A.T.
A role for the small GTPase Rab21 in the early endocytic pathway
J. Cell Sci.
117
6297-6311
2004
Homo sapiens (Q9UL25), Homo sapiens
Spencer, A.G.; Orita, S.; Malone, C.J.; Han, M.
A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans
Proc. Natl. Acad. Sci. USA
98
13132-13137
2001
Caenorhabditis elegans
Chopade, B.A.; Shankar, S.; Sundin, G.W.; Mukhopadhyay, S.; Chakrabarty, A.M.
Characterization of membrane-associated Pseudomonas aeruginosa Ras-like protein Pra, a GTP-binding protein that forms complexes with truncated nucleoside diphosphate kinase and pyruvate kinase to modulate GTP synthesis
J. Bacteriol.
179
2181-2188
1997
Pseudomonas aeruginosa, Pseudomonas aeruginosa 8830
Goehring, U.M.; Schmidt, G.; Pederson, K.J.; Aktories, K.; Barbieri, J.T.
The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases
J. Biol. Chem.
274
36369-36372
1999
Cricetulus griseus
Yu, Y.; Chang, Y.; Li, S.; Hu, H.; Huang, Q.; Ding, J.
Expression, purification, crystallization and preliminary structural characterization of the GTPase domain of human Rheb
Acta Crystallogr. Sect. D
D60
1883-1887
2004
Homo sapiens
Yanuar, A.; Sakurai, S.; Kitano, K.; Hakoshima, T.
Expression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPase
Acta Crystallogr. Sect. F
F61
978-980
2005
Homo sapiens
Araripe, J.R.; Ramos, F.P.; Cunha e Silva, N.L.; Urmenyi, T.P.; Silva, R.; Leite Fontes, C.F.; da Silveira, J.F.; Rondinelli, E.
Characterization of a RAB5 homologue in Trypanosoma cruzi
Biochem. Biophys. Res. Commun.
329
638-645
2005
Trypanosoma cruzi (Q58XP3)
Ramos, F.P.; Araripe, J.R.; Urmenyi, T.P.; Silva, R.; Cunha e Silva, N.L.; Leite Fontes, C.F.; da Silveira, J.F.; Rondinelli, E.
Characterization of RAB-like4, the first identified RAB-like protein from Trypanosoma cruzi with GTPase activity
Biochem. Biophys. Res. Commun.
333
808-817
2005
Trypanosoma cruzi (Q68U42), Trypanosoma cruzi
de Melo, L.D.; Eisele, N.; Nepomuceno-Silva, J.L.; Lopes, U.G.
TcRho1, the Trypanosoma cruzi Rho homologue, regulates cell-adhesion properties: evidence for a conserved function
Biochem. Biophys. Res. Commun.
345
617-622
2006
Trypanosoma cruzi
Kim, H.J.; Triplett, B.A.
Characterization of GhRac1 GTPase expressed in developing cotton (Gossypium hirsutum L.) fibers
Biochim. Biophys. Acta
1679
214-221
2004
Gossypium hirsutum
Paganini, S.; Guidetti, G.F.; Catricala, S.; Trionfini, P.; Panelli, S.; Balduini, C.; Torti, M.
Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins
Biochimie
88
285-295
2006
Homo sapiens
Zou, H.; Hu, L.; Li, J.; Zhan, S.; Cao, K.
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential
Biotechnol. Lett.
28
1901-1908
2006
Homo sapiens
Huber, S.K.; Scheidig, A.J.
High resolution crystal structures of human Rab4a in its active and inactive conformations
FEBS Lett.
579
2821-2829
2005
Homo sapiens
Yanuar, A.; Sakurai, S.; Kitano, K.; Hakoshima, T.
Crystal structure of human Rad GTPase of the RGK-family
Genes Cells
11
961-968
2006
Homo sapiens
Ye, M.; Shima, F.; Muraoka, S.; Liao, J.; Okamoto, H.; Yamamoto, M.; Tamura, A.; Yagi, N.; Ueki, T.; Kataoka, T.
Crystal structure of M-Ras reveals a GTP-bound off state conformation of Ras family small GTPases
J. Biol. Chem.
280
31267-31275
2005
Mus musculus
Guo, A.; Wang, T.; Ng, E.L.; Aulia, S.; Chong, K.H.; Teng, F.Y.; Wang, Y.; Tang, B.L.
Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization
J. Neurosci. Res.
83
1118-1127
2006
Mus musculus
Shutes, A.; Berzat, A.C.; Chenette, E.J.; Cox, A.D.; Der, C.J.
Biochemical analyses of the Wrch atypical Rho family GTPases
Methods Enzymol.
406
11-26
2006
Homo sapiens
OBrien, L.E.; Yu, W.; Tang, K.; Jou, T.S.; Zegers, M.M.; Mostov, K.E.
Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures
Methods Enzymol.
406
676-691
2006
Canis lupus familiaris
Spiliotis, M.; Tappe, D.; Brueckner, S.; Moesch, H.U.; Brehm, K.
Molecular cloning and characterization of Ras- and Raf-homologues from the fox-tapeworm Echinococcus multilocularis
Mol. Biochem. Parasitol.
139
225-237
2005
Echinococcus multilocularis
Yuan, J.; Shan, Y.; Chen, X.; Tang, W.; Luo, K.; Ni, J.; Wan, B.; Yu, L.
Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B
Mol. Biol. Rep.
32
205-214
2005
Homo sapiens (Q8TAI7)
Li, Y.; Inoki, K.; Guan, K.L.
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
Mol. Cell. Biol.
24
7965-7975
2004
Homo sapiens
Zhao, Q.; Leung, S.; Corbett, A.H.; Meier, I.
Identification and characterization of the Arabidopsis orthologs of nuclear transport factor 2, the nuclear import factor of ran
Plant Physiol.
140
869-878
2006
Arabidopsis thaliana
Mitra, B.N.; Saito-Nakano, Y.; Nakada-Tsukui, K.; Sato, D.; Nozaki, T.
Rab11B small GTPase regulates secretion of cysteine proteases in the enteric protozoan parasite Entamoeba histolytica
Cell. Microbiol.
9
2112-2125
2007
Entamoeba histolytica
Chavas, L.M.; Torii, S.; Kamikubo, H.; Kawasaki, M.; Ihara, K.; Kato, R.; Kataoka, M.; Izumi, T.; Wakatsuki, S.
Structure of the small GTPase Rab27b shows an unexpected swapped dimer
Acta Crystallogr. Sect. D
63
769-779
2007
Mus musculus
Zhang, H.; Cybulsky, A.V.; Aoudjit, L.; Zhu, J.; Li, H.; Lamarche-Vane, N.; Takano, T.
Role of Rho-GTPases in complement-mediated glomerular epithelial cell injury
Am. J. Physiol. Renal Physiol.
293
F148-F156
2007
Rattus norvegicus
Giehl, K.; Graness, A.; Goppelt-Struebe, M.
The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression
Am. J. Physiol. Renal Physiol.
294
F407-F413
2008
Rattus norvegicus
Kumei, Y.; Shimokawa, H.; Ohya, K.; Katano, H.; Akiyama, H.; Hirano, M.; Morita, S.
Small GTPase Ras and Rho expression in rat osteoblasts during spaceflight
Ann. N. Y. Acad. Sci.
1095
292-299
2007
Rattus norvegicus
Hirai, F.; Nakayamada, S.; Okada, Y.; Saito, K.; Kurose, H.; Mogami, A.; Tanaka, Y.
Small GTPase Rho signaling is involved in beta1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation
Biochem. Biophys. Res. Commun.
356
279-285
2007
Homo sapiens
Nikolova, E.; Mitev, V.; Zhelev, N.; Deroanne, C.F.; Poumay, Y.
The small Rho GTPase Rac1 controls normal human dermal fibroblasts proliferation with phosphorylation of the oncoprotein c-myc
Biochem. Biophys. Res. Commun.
359
834-839
2007
Homo sapiens
Liao, J.; Shima, F.; Araki, M.; Ye, M.; Muraoka, S.; Sugimoto, T.; Kawamura, M.; Yamamoto, N.; Tamura, A.; Kataoka, T.
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics
Biochem. Biophys. Res. Commun.
369
327-332
2008
Homo sapiens, Mus musculus, Suberites domuncula (A1XKQ5), Suberites domuncula (A1XKQ6), Suberites domuncula (A1XKQ7), Suberites domuncula (A1XKQ8), Suberites domuncula (A1XKQ9), Suberites domuncula (A1XKR0), Suberites domuncula (A1XKR1), Suberites domuncula (A1XKR2), Suberites domuncula (A1XKR3), Suberites domuncula (A1XKR5), Suberites domuncula (A1XKR6), Suberites domuncula (A1XKR7), Suberites domuncula (A1XKR8), Suberites domuncula (A1XKR9), Suberites domuncula (A1XKS0), Suberites domuncula (A1XKS1), Suberites domuncula (A1XKS2), Suberites domuncula (A1XKS3), Suberites domuncula (A1XKS4), Suberites domuncula (A1XKS5), Suberites domuncula (A1XKS6), Suberites domuncula (A1XKS7), Suberites domuncula (A1XKS8), Suberites domuncula (A1XKS9), Suberites domuncula (A1XKT0), Suberites domuncula (A1XKT1), Suberites domuncula (A1XKT2), Suberites domuncula (A1XKT3), Suberites domuncula (A1XKT4), Suberites domuncula (A1XKT5), Suberites domuncula (A1XKT6), Suberites domuncula (A1XKT7), Suberites domuncula (A1XKT8), Suberites domuncula (A1XKT9), Suberites domuncula (A1XKU0), Suberites domuncula (A1XKU1), Suberites domuncula (A1XKU2), Suberites domuncula (A1XKU3), Suberites domuncula (A1XKU4), Suberites domuncula (A1XKU5), Suberites domuncula (O97342), Suberites domuncula (Q4H115), Suberites domuncula (Q4H116)
Charest, P.G.; Firtel, R.A.
Big roles for small GTPases in the control of directed cell movement
Biochem. J.
401
377-390
2007
Dictyostelium sp.
Fu, D.; van Dam, E.M.; Brymora, A.; Duggin, I.G.; Robinson, P.J.; Roufogalis, B.D.
The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein
Biochim. Biophys. Acta
1773
1062-1072
2007
Homo sapiens
Miyano, K.; Sumimoto, H.
Role of the small GTPase Rac in p22phox-dependent NADPH oxidases
Biochimie
89
1133-1144
2007
Homo sapiens
de Gorter, D.J.; Reijmers, R.M.; Beuling, E.A.; Naber, H.P.; Kuil, A.; Kersten, M.J.; Pals, S.T.; Spaargaren, M.
The de Gorter, D.J.; Reijmers, R.M.; Beuling, E.A.; Naber, H.P.; Kuil, A.; Kersten, M.J.; Pals, S.T.; Spaargaren, M.: The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells
Blood
111
3364-3372
2008
Homo sapiens
Burguete, A.S.; Fenn, T.D.; Brunger, A.T.; Pfeffer, S.R.
Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185
Cell
132
286-298
2008
Homo sapiens
Crema, V.O.; Hamassaki, D.E.; Santos, M.F.
Small Rho GTPases are important for acinus formation in a human salivary gland cell line
Cell Tissue Res.
325
493-500
2006
Homo sapiens
Krause-Gruszczynska, M.; Rohde, M.; Hartig, R.; Genth, H.; Schmidt, G.; Keo, T.; Koenig, W.; Miller, W.G.; Konkel, M.E.; Backert, S.
Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni
Cell. Microbiol.
9
2431-2444
2007
Campylobacter jejuni
Martinez-Salgado, C.; Rodriguez-Pena, A.B.; Lopez-Novoa, J.M.
Involvement of small Ras GTPases and their effectors in chronic renal disease
Cell. Mol. Life Sci.
65
477-492
2008
Homo sapiens, Mus musculus
Tzima, E.
Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response
Circ. Res.
98
176-185
2006
Bos taurus
Kevei, E.; Gyula, P.; Feher, B.; Toth, R.; Viczian, A.; Kircher, S.; Rea, D.; Dorjgotov, D.; Schaefer, E.; Millar, A.J.; Kozma-Bognar, L.; Nagy, F.
Arabidopsis thaliana circadian clock is regulated by the small GTPase LIP1
Curr. Biol.
17
1456-1464
2007
Arabidopsis thaliana
Guemar, L.; de Santa Barbara, P.; Vignal, E.; Maurel, B.; Fort, P.; Faure, S.
The small GTPase RhoV is an essential regulator of neural crest induction in Xenopus
Dev. Biol.
310
113-128
2007
Xenopus laevis
Kerr, B.A.; Otani, T.; Koyama, E.; Freeman, T.A.; Enomoto-Iwamoto, M.
Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes
Exp. Cell Res.
314
1301-1312
2008
Gallus gallus
Selvakumar, B.; Hess, D.T.; Goldschmidt-Clermont, P.J.; Stamler, J.S.
Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac
FEBS Lett.
582
2195-2202
2008
Homo sapiens
Kikuchi, Y.; Mizuuchi, E.; Nogami, S.; Morishita, S.; Ohya, Y.
Involvement of Rho-type GTPase in control of cell size in Saccharomyces cerevisiae
FEMS Yeast Res.
7
569-578
2007
Saccharomyces cerevisiae
Wicker-Planquart, C.; Foucher, A.E.; Louwagie, M.; Britton, R.A.; Jault, J.M.
Interactions of an essential Bacillus subtilis GTPase, YsxC, with ribosomes
J. Bacteriol.
190
681-690
2008
Bacillus subtilis
Miyano, K.; Ueno, N.; Takeya, R.; Sumimoto, H.
Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1
J. Biol. Chem.
281
21857-21868
2006
Homo sapiens
Debidda, M.; Williams, D.A.; Zheng, Y.
Rac1 GTPase regulates cell genomic stability and senescence
J. Biol. Chem.
281
38519-38528
2006
Mus musculus
Kawato, M.; Shirakawa, R.; Kondo, H.; Higashi, T.; Ikeda, T.; Okawa, K.; Fukai, S.; Nureki, O.; Kita, T.; Horiuchi, H.
Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway
J. Biol. Chem.
283
166-174
2008
Homo sapiens
Pellinen, T.; Arjonen, A.; Vuoriluoto, K.; Kallio, K.; Fransen, J.A.; Ivaska, J.
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins
J. Cell Biol.
173
767-780
2006
Mus musculus
Mangahas, P.M.; Yu, X.; Miller, K.G.; Zhou, Z.
The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans
J. Cell Biol.
180
357-373
2008
Caenorhabditis elegans
Bidla, G.; Dushay, M.S.; Theopold, U.
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger
J. Cell Sci.
120
1209-1215
2007
Drosophila sp. (in: flies)
Dada, L.A.; Novoa, E.; Lecuona, E.; Sun, H.; Sznajder, J.I.
Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells
J. Cell Sci.
120
2214-2222
2007
Homo sapiens
Tourkova, I.L.; Shurin, G.V.; Wei, S.; Shurin, M.R.
Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells
J. Immunol.
178
7787-7793
2007
Mus musculus
Shurin, G.V.; Tourkova, I.L.; Shurin, M.R.
Low-dose chemotherapeutic agents regulate small Rho GTPase activity in dendritic cells
J. Immunother.
31
491-499
2008
Mus musculus
Fu, Z.; Lee, S.H.; Simonetta, A.; Hansen, J.; Sheng, M.; Pak, D.T.
Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons
J. Neurochem.
100
118-131
2007
Rattus norvegicus
Dombrowski, J.E.; Baldwin, J.C.; Martin, R.C.
Cloning and characterization of a salt stress-inducible small GTPase gene from the model grass species Lolium temulentum
J. Plant Physiol.
165
651-661
2008
Lolium temulentum (A6YDU4), Lolium temulentum
Scapin, S.M.; Carneiro, F.R.; Alves, A.C.; Medrano, F.J.; Guimaraes, B.G.; Zanchin, N.I.
The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform
J. Struct. Biol.
154
260-268
2006
Homo sapiens
Kakihara, K.; Shinmyozu, K.; Kato, K.; Wada, H.; Hayashi, S.
Conversion of plasma membrane topology during epithelial tube connection requires Arf-like 3 small GTPase in Drosophila
Mech. Dev.
125
325-336
2008
Drosophila sp. (in: flies)
Field, M.C.; Horn, D.; Carrington, M.
Analysis of small GTPase function in trypanosomes
Methods Enzymol.
438
57-76
2008
Trypanosoma brucei
Koziel, H.
Rho GTPases in alveolar macrophage phagocytosis
Methods Enzymol.
439
303-313
2008
Homo sapiens
Fernandes, H.; Roumanie, O.; Claret, S.; Gatti, X.; Thoraval, D.; Doignon, F.; Crouzet, M.
The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae
Microbiology
152
695-708
2006
Saccharomyces cerevisiae
Goldfinger, L.E.
Choose your own path: specificity in Ras GTPase signaling
Mol. Biosyst.
4
293-299
2008
Mus musculus
Suzuki, T.; Kanai, Y.; Hara, T.; Sasaki, J.; Sasaki, T.; Kohara, M.; Maehama, T.; Taya, C.; Shitara, H.; Yonekawa, H.; Frohman, M.A.; Yokozeki, T.; Kanaho, Y.
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development
Mol. Cell. Biol.
26
6149-6156
2006
Mus musculus
Caruso, M.E.; Jenna, S.; Bouchecareilh, M.; Baillie, D.L.; Boismenu, D.; Halawani, D.; Latterich, M.; Chevet, E.
GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48
Mol. Cell. Biol.
28
4261-4274
2008
Caenorhabditis elegans
Rolke, Y.; Tudzynski, P.
The small GTPase Rac and the p21-activated kinase Cla4 in Claviceps purpurea: interaction and impact on polarity, development and pathogenicity
Mol. Microbiol.
68
405-423
2008
Claviceps purpurea (B0B5Z8), Claviceps purpurea
Clarke, P.R.; Zhang, C.
Spatial and temporal coordination of mitosis by Ran GTPase
Nat. Rev. Mol. Cell Biol.
9
464-477
2008
Homo sapiens, Mus musculus
Ishikawa, Y.; Katoh, H.; Negishi, M.
Small GTPase Rnd1 is involved in neuronal activity-dependent dendritic development in hippocampal neurons
Neurosci. Lett.
400
218-223
2006
Rattus norvegicus
Zhang, Y.; McCormick, S.
A distinct mechanism regulating a pollen-specific guanine nucleotide exchange factor for the small GTPase Rop in Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
104
18830-18835
2007
Arabidopsis thaliana
Koenig, P.; Oreb, M.; Hoefle, A.; Kaltofen, S.; Rippe, K.; Sinning, I.; Schleiff, E.; Tews, I.
The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures
Structure
16
585-596
2008
Arabidopsis thaliana (O23680), Arabidopsis thaliana, Pisum sativum (Q41009), Pisum sativum
Shen, Y.; Han, Y.J.; Kim, J.I.; Song, P.S.
Arabidopsis nucleoside diphosphate kinase-2 as a plant GTPase activating protein
BMB Rep.
41
645-650
2008
Arabidopsis thaliana
Chavas, L.M.; Ihara, K.; Kawasaki, M.; Kato, R.; Izumi, T.; Wakatsuki, S.
Purification, crystallization and preliminary X-ray crystallographic analysis of Rab27a GTPase in complex with exophilin4/Slp2-a effector
Acta Crystallogr. Sect. F
64
599-601
2008
Mus musculus
Osanai, K.; Oikawa, R.; Higuchi, J.; Kobayashi, M.; Tsuchihara, K.; Iguchi, M.; Jongsu, H.; Toga, H.; Voelker, D.R.
A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice
Am. J. Pathol.
173
1265-1274
2008
Mus musculus
Ganter, M.T.; Roux, J.; Su, G.; Lynch, S.V.; Deutschman, C.S.; Weiss, Y.G.; Christiaans, S.C.; Myazawa, B.; Kipnis, E.; Wiener-Kronish, J.P.; Howard, M.; Pittet, J.F.
Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability
Am. J. Respir. Cell Mol. Biol.
40
108-118
2009
Bos taurus
Kobayashi, T.; Hori, Y.; Ueda, N.; Kajiho, H.; Muraoka, S.; Shima, F.; Kataoka, T.; Kontani, K.; Katada, T.
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome
Biochem. Biophys. Res. Commun.
381
439-442
2009
Homo sapiens
Fenwick, R.; Prasannan, S.; Campbell, L.; Nietlispach, D.; Evetts, K.; Camonis, J.; Mott, H.; Owen, D.
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding
Biochemistry
48
2192-2206
2009
Homo sapiens
Li, H.; Ung, C.Y.; Ma, X.H.; Li, B.W.; Low, B.C.; Cao, Z.W.; Chen, Y.Z.
Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1
Bioinformatics
25
358-364
2009
Homo sapiens
Carmona, G.; Goettig, S.; Orlandi, A.; Scheele, J.; Baeuerle, T.; Jugold, M.; Kiessling, F.; Henschler, R.; Zeiher, A.M.; Dimmeler, S.; Chavakis, E.
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
Blood
113
488-497
2009
Homo sapiens, Mus musculus
Nie, D.; Guo, Y.; Yang, D.; Tang, Y.; Chen, Y.; Wang, M.T.; Zacharek, A.; Qiao, Y.; Che, M.; Honn, K.V.
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho
Cancer Res.
68
115-121
2008
Homo sapiens
Fueller, F.; Kubatzky, K.F.
The small GTPase RhoH is an atypical regulator of haematopoietic cells
Cell Commun. Signal.
6
6-6
2008
Homo sapiens (Q15669), Homo sapiens, Mus musculus (Q9D3G9), Mus musculus
Fuchs, S.; Herzog, D.; Sumara, G.; Buechmann-Moller, S.; Civenni, G.; Wu, X.; Chrostek-Grashoff, A.; Suter, U.; Ricci, R.; Relvas, J.B.; Brakebusch, C.; Sommer, L.
Stage-specific control of neural crest stem cell proliferation by the small Rho GTPases Cdc42 and Rac1
Cell Stem cell
4
236-247
2009
Mus musculus
Lu, Q.; Longo, F.M.; Zhou, H.; Massa, S.M.; Chen, Y.H.
Signaling through Rho GTPase pathway as viable drug target
Curr. Med. Chem.
16
1355-1365
2009
Homo sapiens
Xu, N.; Keung, B.; Myat, M.M.
Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase
Dev. Biol.
321
88-100
2008
Drosophila melanogaster
Atre, A.N.; Surve, S.V.; Shouche, Y.S.; Joseph, J.; Patole, M.S.; Deopurkar, R.L.
Association of small Rho GTPases and actin ring formation in epithelial cells during the invasion by Candida albicans
FEMS Immunol. Med. Microbiol.
55
74-84
2009
Oryctolagus cuniculus, Oryctolagus cuniculus (Q5U814), Oryctolagus cuniculus (Q6DUE5)
Tsao, C.C.; Chen, Y.T.; Lan, C.Y.
A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans
Fungal Genet. Biol.
46
126-136
2009
Candida albicans (Q5ANA9), Candida albicans
Savina, A.; Peres, A.; Cebrian, I.; Carmo, N.; Moita, C.; Hacohen, N.; Moita, L.F.; Amigorena, S.
The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8+ dendritic cells
Immunity
30
544-555
2009
Mus musculus
He, H.; Baldwin, G.S.
Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins
Int. J. Biochem. Cell Biol.
40
2018-2022
2008
Homo sapiens
Yin, J.; Lu, J.; Yu, F.S.
Role of small GTPase Rho in regulating corneal epithelial wound healing
Invest. Ophthalmol. Vis. Sci.
49
900-909
2008
Homo sapiens, Sus scrofa
Lopez, J.A.; Kwan, E.P.; Xie, L.; He, Y.; James, D.E.; Gaisano, H.Y.
The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells
J. Biol. Chem.
283
17939-17945
2008
Mus musculus, Rattus norvegicus
Yoshida, T.; Clark, M.F.; Stern, P.H.
The small GTPase RhoA is crucial for MC3T3-E1 osteoblastic cell survival
J. Cell. Biochem.
106
896-902
2009
Mus musculus
Kimura, T.; Takagi, K.; Hirata, Y.; Hase, Y.; Muto, A.; Himeno, H.
Ribosome-small-subunit-dependent GTPase interacts with tRNA-binding sites on the ribosome
J. Mol. Biol.
381
467-477
2008
Escherichia coli, Escherichia coli A19
Crema, V.O.; Fossati, A.C.; Hamassaki, D.E.; Santos, M.F.
Distribution of small Rho GTPases in the developing rat submandibular gland
J. Mol. Histol.
39
519-525
2008
Rattus norvegicus
Martin, S.; Parton, R.G.
Characterization of Rab18, a lipid droplet-associated small GTPase
Methods Enzymol.
438
109-129
2008
Mus musculus
Williams, D.A.; Zheng, Y.; Cancelas, J.A.
Rho GTPases and regulation of hematopoietic stem cell localization
Methods Enzymol.
439
365-393
2008
Mus musculus
Birukov, K.G.
Small GTPases in mechanosensitive regulation of endothelial barrier
Microvasc. Res.
77
46-52
2009
Homo sapiens
Hayes, G.L.; Brown, F.C.; Haas, A.K.; Nottingham, R.M.; Barr, F.A.; Pfeffer, S.R.
Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi
Mol. Biol. Cell
20
209-217
2009
Homo sapiens
Haditsch, U.; Leone, D.P.; Farinelli, M.; Chrostek-Grashoff, A.; Brakebusch, C.; Mansuy, I.M.; McConnell, S.K.; Palmer, T.D.
A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory
Mol. Cell. Neurosci.
41
409-419
2009
Mus musculus
Ji, P.; Jayapal, S.R.; Lodish, H.F.
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2
Nat. Cell Biol.
10
314-321
2008
Mus musculus
Miller, A.L.; Bement, W.M.
Regulation of cytokinesis by Rho GTPase flux
Nat. Cell Biol.
11
71-77
2009
Xenopus laevis
Speth, E.B.; Imboden, L.; Hauck, P.; He, S.Y.
Subcellular localization and functional analysis of the Arabidopsis GTPase RabE
Plant Physiol.
149
1824-1837
2009
Arabidopsis thaliana
Higashi, M.; Ishikawa, C.; Yu, J.; Toyoda, A.; Kawana, H.; Kurokawa, K.; Matsuda, M.; Kitagawa, M.; Harigaya, K.
Human Mena associates with Rac1 small GTPase in glioblastoma cell lines
PLoS ONE
4
e4765
2009
Homo sapiens
Fueller, F.; Schmidt, G.
The polybasic region of Rho GTPases defines the cleavage by Yersinia enterocolitica outer protein T (YopT)
Protein Sci.
17
1456-1462
2008
Homo sapiens
Wu, H.; Rossi, G.; Brennwald, P.
The ghost in the machine: small GTPases as spatial regulators of exocytosis
Trends Cell Biol.
18
397-404
2008
Mus musculus
Dai, Y.; Walker, S.A.; de Vet, E.; Cook, S.; Welch, H.C.; Lockyer, P.J.
Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities
J. Biol. Chem.
286
19905-19916
2011
Cricetulus griseus
Falchi, R.; Cipriani, G.; Marrazzo, T.; Nonis, A.; Vizzotto, G.; Ruperti, B.
Identification and differential expression dynamics of peach small GTPases encoding genes during fruit development and ripening
J. Exp. Bot.
61
2829-2842
2010
Prunus persica
Dobrin, S.E.; Fahrbach, S.E.
Rho GTPase activity in the honey bee mushroom bodies is correlated with age and foraging experience
J. Insect Physiol.
58
228-234
2012
Apis mellifera
Jeyaraj, S.C.; Unger, N.T.; Chotani, M.A.
Rap1 GTPases: an emerging role in the cardiovasculature
Life Sci.
88
645-652
2011
Homo sapiens, Mus musculus
Zoppino, F.C.; Militello, R.D.; Slavin, I.; Alvarez, C.; Colombo, M.I.
Autophagosome formation depends on the small GTPase Rab1 and functional ER exit sites
Traffic
11
1246-1261
2010
Homo sapiens
Kopra, K.; Ligabue, A.; Wang, Q.; Syrjaenpaeae, M.; Blazevits, O.; Veltel, S.; van Adrichem, A.J.; Haenninen, P.; Abankwa, D.; Haermae, H.
A homogeneous quenching resonance energy transfer assay for the kinetic analysis of the GTPase nucleotide exchange reaction
Anal. Bioanal. Chem.
406
4147-4156
2014
Homo sapiens (P01112), Homo sapiens (P01116), Homo sapiens (P61586)
Stroupe, C.
The yeast vacuolar Rab GTPase Ypt7p has an activity beyond membrane recruitment of the homotypic fusion and protein sorting-Class C Vps complex
Biochem. J.
443
205-211
2012
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Na, R.H.; Zhu, G.H.; Luo, J.X.; Meng, X.J.; Cui, L.; Peng, H.J.; Chen, X.G.; Gomez-Cambronero, J.
Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells
BMC Microbiol.
13
125
2013
Chlorocebus sabaeus (A0A0D9RRD7), Chlorocebus sabaeus (A0A0D9RYP7)
Hatano, T.; Morigasaki, S.; Tatebe, H.; Ikeda, K.; Shiozaki, K.
Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose
Cell Cycle
14
848-856
2015
Schizosaccharomyces pombe
Lee, M.N.; Koh, A.; Park, D.; Jang, J.H.; Kwak, D.; Jeon, H.; Kim, J.; Choi, E.J.; Jeong, H.; Suh, P.G.; Ryu, S.H.
Deacetylated alphabeta-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading
Cell. Signal.
25
539-551
2013
Homo sapiens (Q15382)
Hsiao, B.Y.; Chang, T.K.; Wu, I.T.; Chen, M.Y.
Rad GTPase inhibits the NFkappaB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation
Cell. Signal.
26
1437-1444
2014
Homo sapiens
Zhang, C.; Wang, Y.; Wang, J.; Zhai, Z.; Zhang, L.; Zheng, W.; Zheng, W.; Yu, W.; Zhou, J.; Lu, G.; Shim, W.B.; Wang, Z.
Functional characterization of Rho family small GTPases in Fusarium graminearum
Fungal Genet. Biol.
61
90-99
2013
Fusarium graminearum (A0A098DKM1), Fusarium graminearum (A0A098E0E9), Fusarium graminearum (A0A2H3FHS0), Fusarium graminearum (A0A2H3GRH7), Fusarium graminearum (I1R9M1), Fusarium graminearum (Q4I2W2), Fusarium graminearum, Fusarium graminearum PH-1 (A0A098DKM1), Fusarium graminearum PH-1 (A0A098E0E9), Fusarium graminearum PH-1 (A0A2H3FHS0), Fusarium graminearum PH-1 (A0A2H3GRH7), Fusarium graminearum PH-1 (I1R9M1), Fusarium graminearum PH-1 (Q4I2W2)
Huelsenbeck, S.C.; Roggenkamp, D.; May, M.; Huelsenbeck, J.; Brakebusch, C.; Rottner, K.; Ladwein, M.; Just, I.; Fritz, G.; Schmidt, G.; Genth, H.
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Int. J. Biochem. Cell Biol.
45
1767-1775
2013
Homo sapiens (P62745), Mus musculus (P62746), Mus musculus
Hwang, J.; Tseitin, V.; Ramnarayan, K.; Shenderovich, M.D.; Inouye, M.
Structure-based design and screening of inhibitors for an essential bacterial GTPase, Der
J. Antibiot.
65
237-243
2012
Staphylococcus aureus, Escherichia coli (P0A6P5), Deinococcus radiodurans (Q9RS19), Thermotoga maritima (Q9X1F8), Thermotoga maritima
Kosami, K.; Ohki, I.; Nagano, M.; Furuita, K.; Sugiki, T.; Kawano, Y.; Kawasaki, T.; Fujiwara, T.; Nakagawa, A.; Shimamoto, K.; Kojima, C.
The crystal structure of the plant small GTPase OsRac1 reveals its mode of binding to NADPH oxidase
J. Biol. Chem.
289
28569-28578
2014
Oryza sativa (Q9SSX0), Oryza sativa
Aizawa, M.; Fukuda, M.
Small GTPase Rab2B and its specific binding protein Golgi-associated Rab2B interactor-like 4 (GARI-L4) regulate Golgi morphology
J. Biol. Chem.
290
22250-22261
2015
Homo sapiens (P61006), Homo sapiens (P61019), Homo sapiens (P62820), Homo sapiens (Q8WUD1), Homo sapiens (Q9H0U4), Homo sapiens (Q9NRW1), Homo sapiens
Ferri, N.; Contini, A.; Bernini, S.K.; Corsini, A.
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors
J. Cardiovasc. Pharmacol.
62
425-435
2013
Homo sapiens (P15153), Homo sapiens (P60763), Homo sapiens (P63000)
Moon, M.Y.; Kim, H.J.; Kim, J.G.; Lee, J.Y.; Kim, J.; Kim, S.C.; Choi, I.G.; Kim, P.H.; Park, J.B.
Small GTPase Rap1 regulates cell migration through regulation of small GTPase RhoA activity in response to transforming growth factor-beta1
J. Cell. Physiol.
228
2119-2126
2013
Mus musculus (Q91VL8), Mus musculus (Q9QUI0), Mus musculus C57BL/6 (Q91VL8), Mus musculus C57BL/6 (Q9QUI0)
Kumar, S.; Xu, J.; Kumar, R.S.; Lakshmikanthan, S.; Kapur, R.; Kofron, M.; Chrzanowska-Wodnicka, M.; Filippi, M.D.
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation
J. Exp. Med.
211
1741-1758
2014
Mus musculus (Q99JI6), Mus musculus C57BL/6 (Q99JI6)
Gerasimcik, N.; Dahlberg, C.I.; Baptista, M.A.; Massaad, M.J.; Geha, R.S.; Westerberg, L.S.; Severinson, E.
The Rho GTPase Cdc42 is essential for the activation and function of mature B cells
J. Immunol.
194
4750-4758
2015
Mus musculus, Mus musculus C57BL/6
Mori, R.; Toda, T.
The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2
Mol. Biol. Cell
24; 1713-24
S1-8
2013
Schizosaccharomyces pombe (Q09767), Schizosaccharomyces pombe, Schizosaccharomyces pombe 972 (Q09767)
Shen, D.W.; Pouliot, L.M.; Gillet, J.P.; Ma, W.; Johnson, A.C.; Hall, M.D.; Gottesman, M.M.
The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin
Mol. Pharm.
9
1822-1833
2012
Homo sapiens (P61586), Homo sapiens
Tsai, C.H.; Cheng, H.C.; Wang, Y.S.; Lin, P.; Jen, J.; Kuo, I.Y.; Chang, Y.H.; Liao, P.C.; Chen, R.H.; Yuan, W.C.; Hsu, H.S.; Yang, M.H.; Hsu, M.T.; Wu, C.Y.; Wang, Y.C.
Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis
Nat. Commun.
5
4804
2014
Homo sapiens (Q96AX2), Homo sapiens
Rousset, M.; Cens, T.; Menard, C.; Bowerman, M.; Bellis, M.; Bruses, J.; Raoul, C.; Scamps, F.; Charnet, P.
Regulation of neuronal high-voltage activated CaV2 Ca2+ channels by the small GTPase RhoA
Neuropharmacology
97
201-209
2015
Mus musculus (Q9QUI0)
Mavromatakis, Y.E.; Tomlinson, A.
The role of the small GTPase Rap in Drosophila R7 photoreceptor specification
Proc. Natl. Acad. Sci. USA
109
3844-3849
2012
Drosophila melanogaster (P08645)
Hemsworth, G.R.; Price, H.P.; Smith, D.F.; Wilson, K.S.
Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei
Protein Sci.
22
196-203
2013
Trypanosoma brucei (C9ZVV9), Trypanosoma brucei
Schaefer, A.; Reinhard, N.R.; Hordijk, P.L.
Toward understanding RhoGTPase specificity: structure, function and local activation
Small GTPases
5
6
2014
Homo sapiens (P08134), Homo sapiens (P61586), Homo sapiens (P62745)
Spuul, P.; Ciufici, P.; Veillat, V.; Leclercq, A.; Daubon, T.; Kramer, I.; Genot, E.
Importance of RhoGTPases in formation, characteristics, and functions of invadosomes
Small GTPases
5
e28195
2014
Homo sapiens (P15153), Homo sapiens (P60953), Homo sapiens (P61586), Homo sapiens (P63000)
Knihtila, R.; Volmar, A.Y.; Meilleur, F.; Mattos, C.
Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal application to the small GTPase Ras
Acta Crystallogr. Sect. F
75
111-115
2019
Homo sapiens
Miura, Y.; Kanaho, Y.
ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex
Biochem. Biophys. Res. Commun.
493
1089-1094
2017
Mus musculus (P62331), Mus musculus C57BL/6J (P62331)
Zhang, L.; Dai, F.; Cui, L.; Zhou, B.; Guo, Y.
Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells
Biochim. Biophys. Acta
1864
613-624
2017
Homo sapiens (P51153), Homo sapiens
Yoo, J.; Brady, S.; Acosta-Alvarez, L.; Rogers, A.; Peng, J.; Sorensen, L.; Wolff, R.; Mleynek, T.; Shin, D.; Rich, C.; Kircher, D.; Bild, A.; Odelberg, S.; Li, D.; Holmen, S.; Grossmann, A.
The small GTPase ARf6 activates PI3K in melanoma to induce a prometastatic state
Cancer Res.
79
2892-2908
2019
Homo sapiens (P62330), Homo sapiens, Mus musculus (P62331)
Yang, D.; Roh, S.; Jeong, S.
The axon guidance function of Rap1 small GTPase is independent of PlexA RasGAP activity in Drosophila
Dev. Biol.
418
258-267
2016
Drosophila melanogaster (P08645), Drosophila melanogaster w1118 (P08645)
Feng, Y.; Ma, M.; Zhang, X.; Liu, D.; Wang, L.; Qian, C.; Wei, G.; Zhu, B.
Characterization of small GTPase Rac1 and its interaction with PAK1 in crayfish Procambarus clarkii
Fish Shellfish Immunol.
87
178-183
2019
Procambarus clarkii
Kang, C.H.; Park, J.H.; Lee, E.S.; Paeng, S.K.; Chae, H.B.; Chi, Y.H.; Lee, S.Y.
Exploring novel functions of the small GTPase Ypt1p under heat-shock by characterizing a temperature-sensitive mutant yeast strain, ypt1-G80D
Int. J. Mol. Sci.
20
132
2019
Saccharomyces cerevisiae
Francis, J.W.; Newman, L.E.; Cunningham, L.A.; Kahn, R.A.
A trimer consisting of the tubulin-specific chaperone D (TBCD), regulatory GTPase ARL2, and beta-tubulin is required for maintaining the microtubule network
J. Biol. Chem.
292
4336-4349
2017
Homo sapiens (P36404), Homo sapiens
Carvalho, B.C.; Oliveira, L.C.; Rocha, C.D.; Fernandes, H.B.; Oliveira, I.M.; Leao, F.B.; Valverde, T.M.; Rego, I.M.G.; Ghosh, S.; Silva, A.M.
Both knock-down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF-kappaB activity and inflammatory gene expression
Mol. Immunol.
109
27-37
2019
Mus musculus (Q80ZJ1)
Wong, H.; Akamatsu, A.; Wang, Q.; Higuchi, M.; Matsuda, T.; Okuda, J.; Kosami, K.; Inada, N.; Kawasaki, T.; Kaneko-Kawano, T.; Nagawa, S.; Tan, L.; Kawano, Y.; Shimamoto, K.
In vivo monitoring of plant small GTPase activation using a Foerster resonance energy transfer biosensor
Plant Methods
14
56
2018
Oryza sativa Japonica Group (Q9SSX0), Oryza sativa Japonica Group C5924 (Q9SSX0)
Kaiser, A.; Langer, B.; Przyborski, J.; Kersting, D.; Krueger, M.
A putative non-canonical Ras-like GTPase from P. falciparum chemical properties and characterization of the protein
PLoS ONE
10
e0140994
2015
Plasmodium falciparum (O77338), Plasmodium falciparum
Esposito, A.; Ventura, V.; Petoukhov, M.; Rai, A.; Svergun, D.; Vanoni, M.
Human MICAL1 activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8
Protein Sci.
28
150-166
2019
Homo sapiens (P61006), Homo sapiens
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