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Literature summary for 3.6.5.2 extracted from
- Small GTPase Rab2B and its specific binding protein Golgi-associated Rab2B interactor-like 4 (GARI-L4) regulate Golgi morphology (2015), J. Biol. Chem., 290, 22250-22261.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Rab1A, genome-wide screening for human Rabs that are involved in Golgi morphology in HeLa-S3 cells using specific siRNAs | Homo sapiens |
| Rab1B, genome-wide screening for human Rabs that are involved in Golgi morphology in HeLa-S3 cells using specific siRNAs | Homo sapiens |
| Rab2A, genome-wide screening for human Rabs that are involved in Golgi morphology in HeLa-S3 cells using specific siRNAs | Homo sapiens |
| Rab2B, genome-wide screening for human Rabs that are involved in Golgi morphology in HeLa-S3 cells using specific siRNAs | Homo sapiens |
| Rab6A, genome-wide screening for human Rabs that are involved in Golgi morphology in HeLa-S3 cells using specific siRNAs | Homo sapiens |
| Rab8B, genome-wide screening for human Rabs that are involved in Golgi morphology in HeLa-S3 cells using specific siRNAs | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | knockdown of Rab isoform Rab1A induces fragmentation of the Golgi in HeLa-S3 cells, its phenotype is rescued by re-expression of its siRNA-resistant Rab construct alone, not by any of the other five Rab isozymes | Homo sapiens |
| additional information | knockdown of Rab isoform Rab1B induces fragmentation of the Golgi in HeLa-S3 cells, its phenotype is rescued by re-expression of its siRNA-resistant Rab construct alone, not by any of the other five Rab isozymes | Homo sapiens |
| additional information | knockdown of Rab isoform Rab2B induces fragmentation of the Golgi in HeLa-S3 cells, its phenotype is rescued by re-expression of its siRNA-resistant Rab construct alone, not by any of the other five Rab isozymes | Homo sapiens |
| additional information | knockdown of Rab isoform Rab6A induces fragmentation of the Golgi in HeLa-S3 cells, its phenotype is rescued by re-expression of its siRNA-resistant Rab construct alone, not by any of the other five Rab isozymes | Homo sapiens |
| additional information | knockdown of Rab isoform Rab8B induces fragmentation of the Golgi in HeLa-S3 cells, its phenotype is rescued by re-expression of siRNA-resistant Rab constructs | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| Golgi apparatus | co-localization with effector protein GARI-L4 | Homo sapiens | 5794 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P61006 | - |
- |
| Homo sapiens | P61019 | - |
- |
| Homo sapiens | P62820 | - |
- |
| Homo sapiens | Q8WUD1 | - |
- |
| Homo sapiens | Q9H0U4 | - |
- |
| Homo sapiens | Q9NRW1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Rab1a | - |
Homo sapiens |
| Rab1B | - |
Homo sapiens |
| Rab2A | - |
Homo sapiens |
| Rab2B | - |
Homo sapiens |
| Rab6A | - |
Homo sapiens |
| Rab6B | - |
Homo sapiens |
| small GTPase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | knockdown of Rab isoform Rab2A induces fragmentation of the Golgi in HeLa-S3 cells, its phenotype is rescued by re-expression of its siRNA-resistant Rab construct alone, not by any of the other five Rab isozymes | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | six Rab isoforms are involved in regulating Golgi morphology in HeLa-S3 cells | Homo sapiens |
| physiological function | Rab small GTPases are membrane trafficking proteins. Rab1A non-redundantly regulates Golgi morphology possibly through interaction with an isoform-specific effector molecule | Homo sapiens |
| physiological function | Rab small GTPases are membrane trafficking proteins. Rab1B non-redundantly regulates Golgi morphology possibly through interaction with an isoform-specific effector molecule | Homo sapiens |
| physiological function | Rab small GTPases are membrane trafficking proteins. Rab2A non-redundantly regulates Golgi morphology possibly through interaction with an isoform-specific effector molecule | Homo sapiens |
| physiological function | Rab small GTPases are membrane trafficking proteins. Rab2B non-redundantly regulates Golgi morphology possibly through interaction with an isoform-specific effector molecule. Golgi-associated Rab2B interactor-like 4 (GARI-L4) is a Golgi-resident Rab2B-specific binding protein whose knockdown also induces fragmentation of the Golgi like the knockdown of Rab2B. Effector protein GARI-L4 is required for the compacted Golgi morphology in HeLa-S3 cells | Homo sapiens |
| physiological function | Rab small GTPases are membrane trafficking proteins. Rab6A non-redundantly regulates Golgi morphology possibly through interaction with an isoform-specific effector molecule | Homo sapiens |
| physiological function | Rab small GTPases are membrane trafficking proteins. Rab8B non-redundantly regulates Golgi morphology possibly through interaction with an isoform-specific effector molecule | Homo sapiens |
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