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Literature summary for 3.6.5.2 extracted from
- The ghost in the machine: small GTPases as spatial regulators of exocytosis (2008), Trends Cell Biol., 18, 397-404.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Insulin | RalA is activated upon insulin stimulation in a dose-dependent manner | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | RalA is predominantly localized on the plasma membrane | Mus musculus | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | Rab and Ral GTPases function in exocyst assembly and vesicle-tethering processes, whereas the Rho family of GTPases functions in the local activation of the exocyst complex to facilitate downstream vesicle-fusion events | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | - |
Mus musculus | - |
| adipocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Mus musculus | GDP + phosphate | - |
? | |
| additional information | Rab and Ral GTPases function in exocyst assembly and vesicle-tethering processes, whereas the Rho family of GTPases functions in the local activation of the exocyst complex to facilitate downstream vesicle-fusion events | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdc42 | Cdc42 is a cell-cycle-specific regulator of exocytosis | Mus musculus |
| Rab GTPase | - |
Mus musculus |
| Ral GTPase | - |
Mus musculus |
| Rho GTPase | - |
Mus musculus |
| Rho1 | Rho1 is important for the localization of the Sec3 component of the exocyst complex | Mus musculus |
| Rho3 | Rho3 is a direct regulator of exocytosis | Mus musculus |
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