3.5.4.3: guanine deaminase
This is an abbreviated version!
For detailed information about guanine deaminase, go to the full flat file.
Word Map on EC 3.5.4.3
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3.5.4.3
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xanthine
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purine
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deamination
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uric
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agdas
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hypoxanthine
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anogenital
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8-azaguanine
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anus
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penis
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scrotum
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medicine
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cephalad
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deaminases
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drug development
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analysis
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food industry
- 3.5.4.3
- xanthine
- purine
-
deamination
-
uric
-
agdas
- hypoxanthine
-
anogenital
- 8-azaguanine
-
anus
-
penis
-
scrotum
- medicine
-
cephalad
- deaminases
- drug development
- analysis
- food industry
Reaction
Synonyms
Agdap, cypin, cytosolic PSD-95 interactor, E. coli guanine deaminase, GAH, GDA, GDEase, GUA, guaD, guanase, guanine aminase, Guanine aminohydrolase, guanine deaminase, GUD1, human guanine deaminase, KLLAOD9492, More, NE0047, p51-nedasin, YgfP
ECTree
3.5.4.3 guanine deaminaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.5.4.3 - guanine deaminase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(6R)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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competitive inhibition
(6S)-6-hydroxy-3-beta-D-ribofuranosyl-3a,4,5,6,7,8a-hexahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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competitive inhibition
1-(4-methoxybenzyl)-4-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8-(1H)-one
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1-(4-methoxybenzyl)-4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
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3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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3-(4-methoxybenzyl)-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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3-(4-methoxybenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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3-benzyl-5-butoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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3-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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3-benzyl-5-hydroxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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3-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
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competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group
4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
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4-chloromercuribenzoate
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the deaminase activities for both 7,8-dihydropterin and guanine are completely inhibited in the presence of 1 mM 4-chloromercuribenzoate
5-methoxy-1-(4-methoxybenzyl)-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
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6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
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competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group
6-hydroxy-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
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i.e. azepinomycin
allopurinol
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at concentrations of 1 and 10 mM, potassium fluoride shows weak inhibitory effect on both, guanine deaminase activity (5.2 and 11% inhibition) and dihydropterin deaminase activity (6.2 and 10.1% inhibition)
guanosine
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at concentrations of 1 and 10 mM, guanosine shows weak inhibitory effect on both, guanine deaminase activity (1.8 and 12.5% inhibition) and dihydropterin deaminase activity (3.8 and 5.1% inhibition)
KCN
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KCN inhibits dihydropterin deaminase activity strongly 98.6% inhibition at 10 mM whereas it has almost no inhibitory effect on guanine deaminase activity at the same concentration
lumazine
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at concentrations of 1 and 10 mM, allopurinol shows weak inhibitory effect on both, guanine deaminase activity (4.5 and 17.8% inhibition) and dihydropterin deaminase activity (3.2 and 10% inhibition)
potassium fluoride
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at concentrations of 1 and 10 mM, potassium fluoride shows weak inhibitory effect on both, guanine deaminase activity (3.6 and 8.1% inhibition) and dihydropterin deaminase activity (0 and 1.2% inhibition)
pterin
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pterin strongly inhibits guanine deaminase activity (57.8% inhibition at 1 mM), whereas it has a weak effect on dihydropterin deaminase activity
additional information
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not inhibited by EDTA, 1,10-phenanthroline, dithiothreitol, L-cysteine, and phenylmethylsulfonyl fluoride
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5-aminoimidazole-4-carboxamide
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adenine
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at concentrations of 1 and 10 mM, adenine shows weak inhibitory effect on both, guanine deaminase activity (7.1 and 24% inhibition) and dihydropterin deaminase activity (10.3 and 14.1% inhibition)
adenosine
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at concentrations of 1 and 10 mM, adenosine shows weak inhibitory effec on both, guanine deaminase activity (5.6 and 22.7% inhibition) and dihydropterin deaminase activity (11.5 and 16.7% inhibition)
azepinomycin
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naturally occuring guanase inhibitor, antitumor antibiotic
F-
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inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5
F-
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inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5
F-
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inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5
iodoacetic acid
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0.1 mM 7% loss in the activity, 1 mM 29% loss in the activity after 30 min incubation
natural inhibitor protein
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heat labile proteinous mitochondrial inhibitor for liver and brain enzyme
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p-hydroxymercuribenzoate
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noncompetitive inhibitor, 0.1 mM, 37°C, rapid inactivation
p-hydroxymercuribenzoate
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0.0001 M 91% loss of activity after 30 min incubation
p-hydroxymercuribenzoate
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isoenzyme B more rapidly inactivated and the inhibition is less effectively reversed by thiol supplements than isoenzyme A
