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3.5.4.3: guanine deaminase

This is an abbreviated version!
For detailed information about guanine deaminase, go to the full flat file.

Word Map on EC 3.5.4.3

Reaction

guanine
+
H2O
=
xanthine
+
NH3

Synonyms

Agdap, cypin, cytosolic PSD-95 interactor, E. coli guanine deaminase, GAH, GDA, GDEase, GUA, guaD, guanase, guanine aminase, Guanine aminohydrolase, guanine deaminase, GUD1, human guanine deaminase, KLLAOD9492, More, NE0047, p51-nedasin, YgfP

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.3 guanine deaminase

Substrates Products

Substrates Products on EC 3.5.4.3 - guanine deaminase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-methylguanine + H2O
1-methylxanthine + NH3
show the reaction diagram
-
-
-
?
2,6-diaminopurine + H2O
?
show the reaction diagram
-
the native enzyme shows 107% activity and the recombinant enzyme 98% activity compared to guanine
-
-
?
2,6-diaminopurine + H2O
xanthine + NH3
show the reaction diagram
-
-
-
-
?
2-amino-6-chloropurine + H2O
6-chloro-3,9-dihydro-2H-purin-2-one + NH3
show the reaction diagram
-
-
-
-
?
2-amino-6-chloropurine + H2O
6-chloro-9H-purin-2-ol + NH3
show the reaction diagram
-
the native enzyme shows 93% activity and the recombinant enzyme 88% activity compared to guanine
-
-
?
2-amino-6-methoxypurine + H2O
6-methoxy-3,9-dihydro-2H-purin-2-one + NH3
show the reaction diagram
-
-
-
-
?
6-thioguanine + H2O
6-thioxanthine + NH3
show the reaction diagram
7,8-dihydropterin + H2O
7,8-dihydrolumazine + NH3
show the reaction diagram
8-azaguanine + H2O
8-azaxanthine + NH3
show the reaction diagram
8-azaguanine + H2O
?
show the reaction diagram
8-azaxanthine + H2O
8-azaxanthine + HCl
show the reaction diagram
-
-
-
-
?
8-azaxanthine + H2O
?
show the reaction diagram
-
the native enzyme shows 95% activity and the recombinant enzyme 88% activity compared to guanine
-
-
?
adenine + H2O
allopurinol + NH3
show the reaction diagram
adenosine + H2O
inosine + NH3
show the reaction diagram
ammelide + H2O
cyanuric acid + NH3
show the reaction diagram
the absolute activity toward ammelide is 7 orders of magnitude lower than the activity of wild type GDA for guanine
-
-
?
ammeline + H2O
?
show the reaction diagram
-
-
-
?
ammeline + H2O
? + NH3
show the reaction diagram
ammeline + H2O
ammelide + NH3
show the reaction diagram
AMP + H2O
IMP + NH3
show the reaction diagram
-
-
-
-
?
cytidine + H2O
uridine + NH3
show the reaction diagram
-
-
-
-
?
cytosine + H2O
6-hydroxy-1H-pyrimidin-2-one + NH3
show the reaction diagram
-
-
-
-
?
GMP + H2O
XMP + NH3
show the reaction diagram
-
-
-
-
?
guanine + H2O
xanthine + NH3
show the reaction diagram
guanosine + H2O
?
show the reaction diagram
guanosine + H2O
xanthosine + NH3
show the reaction diagram
-
-
-
-
?
hypoxanthine + H2O
?
show the reaction diagram
-
the native enzyme shows 100% activity and the recombinant enzyme 87% activity compared to guanine
-
-
?
uric acid + H2O
?
show the reaction diagram
xanthine + H2O
?
show the reaction diagram
-
the native enzyme shows 01% activity and the recombinant enzyme 87% activity compared to guanine
-
-
?
additional information
?
-