3.5.4.3: guanine deaminase
This is an abbreviated version!
For detailed information about guanine deaminase, go to the full flat file.
Word Map on EC 3.5.4.3
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3.5.4.3
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xanthine
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purine
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deamination
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uric
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agdas
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hypoxanthine
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anogenital
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8-azaguanine
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anus
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penis
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scrotum
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medicine
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cephalad
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deaminases
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drug development
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analysis
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food industry
- 3.5.4.3
- xanthine
- purine
-
deamination
-
uric
-
agdas
- hypoxanthine
-
anogenital
- 8-azaguanine
-
anus
-
penis
-
scrotum
- medicine
-
cephalad
- deaminases
- drug development
- analysis
- food industry
Reaction
Synonyms
Agdap, cypin, cytosolic PSD-95 interactor, E. coli guanine deaminase, GAH, GDA, GDEase, GUA, guaD, guanase, guanine aminase, Guanine aminohydrolase, guanine deaminase, GUD1, human guanine deaminase, KLLAOD9492, More, NE0047, p51-nedasin, YgfP
ECTree
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Substrates Products
Substrates Products on EC 3.5.4.3 - guanine deaminase
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REACTION DIAGRAM
2,6-diaminopurine + H2O
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the native enzyme shows 107% activity and the recombinant enzyme 98% activity compared to guanine
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?
2-amino-6-chloropurine + H2O
6-chloro-3,9-dihydro-2H-purin-2-one + NH3
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?
2-amino-6-chloropurine + H2O
6-chloro-9H-purin-2-ol + NH3
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the native enzyme shows 93% activity and the recombinant enzyme 88% activity compared to guanine
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?
2-amino-6-methoxypurine + H2O
6-methoxy-3,9-dihydro-2H-purin-2-one + NH3
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?
8-azaxanthine + H2O
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the native enzyme shows 95% activity and the recombinant enzyme 88% activity compared to guanine
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-
?
ammelide + H2O
cyanuric acid + NH3
the absolute activity toward ammelide is 7 orders of magnitude lower than the activity of wild type GDA for guanine
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?
hypoxanthine + H2O
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the native enzyme shows 100% activity and the recombinant enzyme 87% activity compared to guanine
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xanthine + H2O
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the native enzyme shows 01% activity and the recombinant enzyme 87% activity compared to guanine
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?
6-thioguanine + H2O
6-thioxanthine + NH3
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-
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?
7,8-dihydrolumazine + NH3
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the enzyme exhibits 40fold higher activity for guanine than for 7,8-dihydropterin. Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin
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?
7,8-dihydropterin + H2O
7,8-dihydrolumazine + NH3
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the enzyme exhibits 40fold higher activity for guanine than for 7,8-dihydropterin. Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin
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?
8-azaxanthine + NH3
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the native enzyme shows 99% activity and the recombinant enzyme 95% activity compared to guanine
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8-azaguanine + H2O
8-azaxanthine + NH3
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the native enzyme shows 99% activity and the recombinant enzyme 95% activity compared to guanine
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?
8-azaguanine + H2O
8-azaxanthine + NH3
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high substrate specificity, only 60% of the reaction rate with the natural substrate guanine
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8-azaguanine + H2O
8-azaxanthine + NH3
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?
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the enzyme shows 60% activity for 8-azaguanine relative to 7,8-dihydropterin
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-
?
8-azaguanine + H2O
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the enzyme shows 60% activity for 8-azaguanine relative to 7,8-dihydropterin
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?
allopurinol + NH3
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the native enzyme shows 102% activity and the recombinant enzyme 85% activity compared to guanine
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adenine + H2O
allopurinol + NH3
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the native enzyme shows 102% activity and the recombinant enzyme 85% activity compared to guanine
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inosine + NH3
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the native enzyme shows 98% activity and the recombinant enzyme 91% activity compared to guanine
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?
adenosine + H2O
inosine + NH3
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the native enzyme shows 98% activity and the recombinant enzyme 91% activity compared to guanine
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?
guanine + H2O
xanthine + NH3
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substrate binding structure and tautomerization of the bound guanine, reaction steps in a detailed overview
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guanine + H2O
xanthine + NH3
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?
guanine + H2O
xanthine + NH3
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enzyme shows activity toward guanine not toward adenine
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?
guanine + H2O
xanthine + NH3
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209584, 209586, 209587, 209591, 209592, 209593, 209594, 209595, 209601, 667985, 711469, 733480, 733496
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?
guanine + H2O
xanthine + NH3
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reaction via tetrahedral intermediate
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guanine + H2O
xanthine + NH3
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?
guanine + H2O
xanthine + NH3
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the enzyme plays a central role in neuronal development, and an active role in regulating dendrite branching in hippocampal neurons, cypin-promoted increases in dendrite number are dependent on its zinc-dependent guanine deaminase activity, overview
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the native enzyme shows 48% activity and the recombinant enzyme 70% activity compared to guanine
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guanosine + H2O
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the enzyme shows 5% activity for guanosine relative to 7,8-dihydropterin
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guanosine + H2O
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the enzyme shows 5% activity for guanosine relative to 7,8-dihydropterin
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the native enzyme shows 89% activity and the recombinant enzyme 86% activity compared to guanine
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uric acid + H2O
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the native enzyme shows 89% activity and the recombinant enzyme 86% activity compared to guanine
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?
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the enzyme does not metabolize ammelide or melamine
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?
additional information
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the enzyme does not metabolize ammelide or melamine
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additional information
?
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the enzyme has no deaminase activities for other dihydropteridines such as 7,8-dihydrobiopterin, 7,8-dihydroneopterin, and sepiapterin, it also does not show deaminase activity with fully oxidized pteridines such as pterin, biopterin, neopterin, monapterin, xanthopterin, isoxanthopterin, aminopterin, 6-formylpterin, 6-carboxypterin, and 6-hydroxymethylpterin. Moreover the enzyme does not use folic acid, pyrimidodiazepine, drosopterin, or isodrosopterin as a substrate. No activity is found for adenine and adenosine
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additional information
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the enzyme has no deaminase activities for other dihydropteridines such as 7,8-dihydrobiopterin, 7,8-dihydroneopterin, and sepiapterin, it also does not show deaminase activity with fully oxidized pteridines such as pterin, biopterin, neopterin, monapterin, xanthopterin, isoxanthopterin, aminopterin, 6-formylpterin, 6-carboxypterin, and 6-hydroxymethylpterin. Moreover the enzyme does not use folic acid, pyrimidodiazepine, drosopterin, or isodrosopterin as a substrate. No activity is found for adenine and adenosine
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additional information
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the enzyme does not metabolize ammelide or melamine
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additional information
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9-methylguanine, 6-O-methylguanine, 6-thioguanine, and 2,6-diaminopurine, also exhibit measurable activity but turn over very slowly, i.e. below 0.001 per s
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additional information
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9-methylguanine, 6-O-methylguanine, 6-thioguanine, and 2,6-diaminopurine, also exhibit measurable activity but turn over very slowly, i.e. below 0.001 per s
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additional information
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nedasin, an enzyme involved in synaptic connections between neurons binding to neuronal and endocrine lethal discs large, might be an isozyme of guanase, overview
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additional information
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the enzyme does not metabolize ammelide or melamine
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additional information
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the enzyme does not metabolize ammelide or melamine
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additional information
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the enzyme does not metabolize ammelide or melamine
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?