Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.3 extracted from

  • Gupta, N.K.; Glantz, M.D.
    Isolation and characterization of human liver guanine deaminase (1985), Arch. Biochem. Biophys., 236, 266-276.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-aminoimidazole-4-carboxamide
-
Homo sapiens
5-aminoimidazole-4-carboxamide
-
Oryctolagus cuniculus
5-aminoimidazole-4-carboxamide
-
Rattus norvegicus
5-aminoimidazole-4-carboxamide ribonucleoside
-
Oryctolagus cuniculus
5-aminoimidazole-4-carboxamide ribonucleoside
-
Rattus norvegicus
iodoacetamide 2 mM mildly inhibitory Oryctolagus cuniculus
iodoacetic acid 0.1 mM 7% loss in the activity, 1 mM 29% loss in the activity after 30 min incubation Homo sapiens
iodoacetic acid
-
Oryctolagus cuniculus
p-hydroxymercuribenzoate 0.0001 M 91% loss of activity after 30 min incubation Homo sapiens
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
p-hydroxymercuribenzoate
-
Rattus norvegicus
tetrahydrofolic acid
-
Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0038
-
guanine
-
Oryctolagus cuniculus
0.0042
-
guanine
-
Bos taurus
0.0056
-
guanine
-
Homo sapiens
0.0056
-
guanine
-
Oryctolagus cuniculus
0.011
-
guanine
-
Sus sp.
0.0125
-
guanine at pH 7 Oryctolagus cuniculus
0.0153
-
guanine at pH 6 Homo sapiens
0.0156
-
guanine at pH 8.0 Homo sapiens
0.0166
-
guanine at pH 7.0 Homo sapiens
0.0178
-
guanine at pH 7.5 Homo sapiens
0.0182
-
guanine
-
Oryctolagus cuniculus
0.0182
-
guanine at pH 6 Homo sapiens
0.02
-
guanine at pH 6.5 Homo sapiens
0.0313
-
guanine at pH 5.5 Homo sapiens
0.037
-
guanine at pH 9.0 Homo sapiens
0.0417
-
guanine at pH 8.5 Homo sapiens
0.105
-
guanine
-
Oryctolagus cuniculus
0.17
-
guanine
-
Rattus norvegicus
0.2
-
8-Azaguanine at pH 6 Homo sapiens
0.23
-
8-Azaguanine
-
Oryctolagus cuniculus
0.33
-
8-Azaguanine
-
Sus sp.
0.333
-
8-Azaguanine at pH 6 Oryctolagus cuniculus
0.67
-
8-Azaguanine
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
2 * 50000, SDS-PAGE Homo sapiens
50000
-
2 * 50000, SDS-PAGE Oryctolagus cuniculus
50000
-
2 * 50000, SDS-PAGE Sus sp.
52000
-
2 * 52000, brain and liver enzymes, SDS-PAGE Rattus norvegicus
52000
-
2 * 52000, brain and liver enzymes, SDS-PAGE Bos taurus
52000
-
2 * 52000, brain and liver enzymes, SDS-PAGE Oryctolagus cuniculus
55000
-
-
Homo sapiens
55000
-
liver, single polypeptide chain, gel filtration Rattus norvegicus
55000
-
liver, single polypeptide chain, gel filtration Oryctolagus cuniculus
55000
-
2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
59000
-
-
Oryctolagus cuniculus
59000
-
2 * 59000, SDS-PAGE Homo sapiens
95000
-
-
Bos taurus
100000
-
-
Homo sapiens
100000
-
2 forms of liver enzyme Oryctolagus cuniculus
105000
-
-
Rattus norvegicus
105000
-
-
Bos taurus
110000
-
-
Rattus norvegicus
110000
-
-
Sus sp.
110000
-
liver, gel filtration Homo sapiens
110000
-
liver, gel filtration Oryctolagus cuniculus
120000
-
gel filtration Homo sapiens
170000
-
2 forms of liver enzyme Oryctolagus cuniculus
200000
-
-
Homo sapiens
207000
-
2 forms of liver enzyme Oryctolagus cuniculus
525000
-
2 forms of liver enzyme Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanine + H2O Homo sapiens
-
xanthine + NH3
-
?
guanine + H2O Rattus norvegicus
-
xanthine + NH3
-
?
guanine + H2O Bos taurus
-
xanthine + NH3
-
?
guanine + H2O Oryctolagus cuniculus
-
xanthine + NH3
-
?
guanine + H2O Sus sp.
-
xanthine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
cow
-
Homo sapiens
-
human
-
Oryctolagus cuniculus
-
rabbit
-
Rattus norvegicus
-
rat
-
Sus sp.
-
pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Bos taurus
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Bos taurus
-
liver
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
21.5
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-thioguanine + H2O
-
Oryctolagus cuniculus 6-thioxanthine + NH3
-
?
6-thioguanine + H2O
-
Sus sp. 6-thioxanthine + NH3
-
?
8-azaguanine + H2O
-
Homo sapiens 8-azaxanthine + NH3
-
?
8-azaguanine + H2O
-
Rattus norvegicus 8-azaxanthine + NH3
-
?
8-azaguanine + H2O
-
Oryctolagus cuniculus 8-azaxanthine + NH3
-
?
8-azaguanine + H2O
-
Sus sp. 8-azaxanthine + NH3
-
?
guanine + H2O
-
Homo sapiens xanthine + NH3
-
?
guanine + H2O
-
Rattus norvegicus xanthine + NH3
-
?
guanine + H2O
-
Bos taurus xanthine + NH3
-
?
guanine + H2O
-
Oryctolagus cuniculus xanthine + NH3
-
?
guanine + H2O
-
Sus sp. xanthine + NH3
-
?

Subunits

Subunits Comment Organism
dimer 2 * 50000, SDS-PAGE Homo sapiens
dimer 2 * 50000, SDS-PAGE Oryctolagus cuniculus
dimer 2 * 50000, SDS-PAGE Sus sp.
dimer 2 * 59000, SDS-PAGE Homo sapiens
dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Homo sapiens
dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Oryctolagus cuniculus
dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
dimer 2 * 52000, brain and liver enzymes, SDS-PAGE Rattus norvegicus
dimer 2 * 52000, brain and liver enzymes, SDS-PAGE Bos taurus
dimer 2 * 52000, brain and liver enzymes, SDS-PAGE Oryctolagus cuniculus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
-
Oryctolagus cuniculus
40
-
stable up to Homo sapiens
45
-
relatively stable, incubation for 5 min, 3% loss in activity, 17% after 30 min Homo sapiens
55
-
-
Oryctolagus cuniculus
55
-
becomes labile at, loses 21% of activity after 5 min incubation, 49% after 30 min Homo sapiens
65
-
activity completely lost after 30 min incubation Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.9
-
liver enzyme Oryctolagus cuniculus
6
-
8-azaguanine as substrate Homo sapiens
6
-
8-azaguanine as substrate Oryctolagus cuniculus
6.8
-
-
Oryctolagus cuniculus
8
-
-
Homo sapiens
8
-
-
Rattus norvegicus
8
-
-
Oryctolagus cuniculus

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9
-
Homo sapiens