3.5.4.12: dCMP deaminase This is an abbreviated version! For detailed information about dCMP deaminase, go to the full flat file .
Reaction
dCMP +
H2O =
dUMP +
NH3
Synonyms 2-deoxycytidylate deaminase, 5-mdCMP deaminase, 5-methyldeoxycytidine monophosphate deaminase, DCD, DCD1, dCDA, dCMP deaminase, dCMP-aminohydrolase, dCMP-dCTP deaminase, dCMPase, dCMPD, deaminase, deoxycytidylate, deoxy-CMP-deaminase, deoxycytidine deaminase, deoxycytidine monophosphate deaminase, deoxycytidine nucleotide deaminase, deoxycytidine-5'-monophosphate aminohydrolase, deoxycytidine-5'-monophosphate deaminase, deoxycytidine-5'-phosphate deaminase, deoxycytidylate aminohydrolase, deoxycytidylate deaminase, ST2 protein, STRIPE2, T2-dCMP deaminase, T2-deoxycytidylate deaminase, T2-phage deoxycytidylate deaminase, T4-dCMP deaminase, T4-deaminase, T4-phage deoxycytidylate deaminase
ECTree
Subunits
Subunits on EC 3.5.4.12 - dCMP deaminase
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dimer
-
2 * 53000, SDS-PAGE
dimer
Tequatrovirus T4
-
2 * 21200, mutant R115E: dimer, mutants R115Q and F112A varies from hexamers to dimers or something in between depending on protein concentration, HPLC gel filtration in the presence of SDS
dimer
Tequatrovirus T4
-
mutants R115Q and R115E, mutant F112A changes between dimeric and hexameric forms
dimer
Tequatrovirus T4
-
the mutant R115E is dimeric in solution, while hexameric in crystals, quarternary structure analysis
hexamer
-
6 identical subunits
hexamer
-
6 identical subunits
hexamer
-
6 * 20000, SDS-PAGE
hexamer
-
6 * 18842, amino acid analysis
hexamer
-
6 identical subunits
hexamer
-
hexamer is the active form
hexamer
-
6 * 20200, sedimentation in 6 M guanidine hydrochloride containing 0.1 M 2-mercaptoethanol and SDS-PAGE
hexamer
-
6 identical subunits
hexamer
-
6 identical subunits
hexamer
-
6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence
hexamer
-
6 * 20000, SDS-PAGE
hexamer
6 * 17000, SDS-PAGE
hexamer
-
6 identical subunits
hexamer
-
homohexamer, subunits adopt a three-layer alpha/beta/alpha sandwich fold
hexamer
Tequatrovirus T4
-
6 identical subunits
hexamer
Tequatrovirus T4
-
6 * 21200, wild-type, particularly in the presence of dCTP: hexamer, mutants R115Q and F112A varies from hexamers to dimers or something in between depending on protein concentration, HPLC gel filtration in the presence of SDS
hexamer
Tequatrovirus T4
-
wild-type enzyme, mutant F112A changes between dimeric and hexameric forms
additional information
-
monomeric and quarternary structure analysis, overview
additional information
Tequatrovirus T4
-
hexameric form of enzyme is activated by dCTP, while the dimer is not