3.5.4.12: dCMP deaminase

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For detailed information about dCMP deaminase, go to the full flat file.

Reaction

Synonyms

2-deoxycytidylate deaminase, 5-mdCMP deaminase, 5-methyldeoxycytidine monophosphate deaminase, DCD, DCD1, dCDA, dCMP deaminase, dCMP-aminohydrolase, dCMP-dCTP deaminase, dCMPase, dCMPD, deaminase, deoxycytidylate, deoxy-CMP-deaminase, deoxycytidine deaminase, deoxycytidine monophosphate deaminase, deoxycytidine nucleotide deaminase, deoxycytidine-5'-monophosphate aminohydrolase, deoxycytidine-5'-monophosphate deaminase, deoxycytidine-5'-phosphate deaminase, deoxycytidylate aminohydrolase, deoxycytidylate deaminase, ST2 protein, STRIPE2, T2-dCMP deaminase, T2-deoxycytidylate deaminase, T2-phage deoxycytidylate deaminase, T4-dCMP deaminase, T4-deaminase, T4-phage deoxycytidylate deaminase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.12 dCMP deaminase

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Results	in table
118	Activating Compound
977	AA Sequence
6	Application
1	CAS Registry Number
12	Cloned(Commentary)
1	Cofactor
6	Crystallization (Commentary)
264	Disease/ Diagnostics
3	General Information
44	General Stability
129	Inhibitors
6	Ki Value [mM]
59	KM Value [mM]
1	Localization
63	Metals/Ions
30	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
83	Organism
5	Pathway
12	PDB ID
31	pH Optimum
4	pH Range
20	Protein Variants
33	Purification (Commentary)
90	Reaction
1	Reaction Type
71	Reference
3	Renatured (Commentary)
46	Source Tissue
19	Specific Activity [micromol/min/mg]
16	Storage Stability
238	Substrates and Products (Substrate)
43	Subunits
49	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
1	Temperature Range [°C]
12	Temperature Stability [°C]
12	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.5.4.12 - dCMP deaminase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

bound to dTTP, hanging drop vapor diffusion method, using 0.2 M potassium formate, 20% (w/v) PEG 3350

Cyanophage S-TIM5

H6WFU3

734322

-

Escherichia phage T2

-

288997, 289020

dCMP deaminase in complex with dCTP and an intermediate analogue, X-ray diffraction structure determination and analysis at 1.66-3.0 A resolution, the crystal structure of the free-state enzyme is determined by the zinc multiwavelength anomalous dispersion, MAD, method

Streptococcus mutans

-

688405

sitting-drop vapour-diffusion method at 4°C. Crystal structure of the enzyme complexed with dTTP is presented at 2.35 A resolution

Streptococcus mutans

Q8DSE5

755720

purified mutant R115E free or in complex with active site binding inhibitor pyrimidin-2-one deoxyribotide, the mutant R115E is dimeric in solution, while hexameric in crystals, hanging drop vapour diffusion method, 0.28 mM mutant R115E protein in 20 mM phosphate, pH 7.2, 0.38 mM inhibitor, and 30 mM DTT, is mixed with an equal volume of reservoir solution containing 1.3 M ammonium sulfate, 0.1 M sodium citrate, pH 6.0, and 10 mM DTT, 22°C, 3 weeks, X-ray diffraction structure determination and analysis at 2.2 A resolution

Tequatrovirus T4

-

667587