Any feedback?
Literature summary for 3.5.4.12 extracted from
- A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase (1990), Prog. Nucleic Acid Res. Mol. Biol., 39, 49-80.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dCTP | - |
Bacillus subtilis |  |
| dCTP | - |
Saccharomyces cerevisiae | |
| dCTP | - |
Herpes simplex virus | |
| dCTP | positive allosteric effector | Gallus gallus | |
| dCTP | positive allosteric effector | Homo sapiens | |
| dCTP | positive allosteric effector | Rattus norvegicus | |
| dCTP | positive allosteric effector | Tequatrovirus T4 | |
| dCTP | positive allosteric effector | Equus asinus | |
| dCTP | positive allosteric effector | Escherichia phage T2 | |
| dCTP | positive allosteric effector | Enterobacteria phage T6 | |
| dCTP | activation by dCTP is reversed by addition of dTTP | Gallus gallus | |
| dCTP | activation by dCTP is reversed by addition of dTTP | Homo sapiens | |
| dCTP | dCTP promotes an aggregation of enzyme subunits to the active state | Gallus gallus | |
| dCTP | dCTP promotes an aggregation of enzyme subunits to the active state | Escherichia phage T2 | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | associated mainly with dividing tissues, potential diagnostic tool for various disease states in which enzyme is elevated | Homo sapiens |
| pharmacology | might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents | Equus asinus |
| pharmacology | enzyme might be a reasonable target for chemotherapeutic agents directed against parasitic as well as neoplastic diseases by limiting the synthesis of dUMP, particularly when used in combination with inhibitors of dTMP synthase or other purine and pyrimidine inhibitors of DNA synthesis | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Tequatrovirus T4 |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Escherichia phage T2 |
General Stability
| General Stability | Organism |
|---|---|
| dCTP stabilizes | Gallus gallus |
| dCTP stabilizes | Tequatrovirus T4 |
| dCTP stabilizes | Escherichia phage T2 |
| dCTP stabilizing hexameric state, dTTP destabilizing | Equus asinus |
| dCTP stabilizing hexameric state, dTTP destabilizing | Escherichia phage T2 |
| enzyme is unstable | Gallus gallus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dTTP | allosteric inhibitor | Enterobacteria phage T6 | |
| dTTP | allosteric inhibitor | Equus asinus | |
| dTTP | allosteric inhibitor; dTTP favores disaggregated or inhibited state | Escherichia phage T2 | |
| dTTP | allosteric inhibitor; dTTP favores disaggregated or inhibited state | Gallus gallus | |
| dTTP | - |
Herpes simplex virus | |
| dTTP | allosteric inhibitor | Homo sapiens | |
| dTTP | allosteric inhibitor | Rattus norvegicus | |
| dTTP | allosteric inhibitor | Tequatrovirus T4 | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Gallus gallus | |
| additional information | - |
additional information | - |
Bacillus subtilis | |
| additional information | - |
additional information | - |
Homo sapiens | |
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | - |
Saccharomyces cerevisiae | |
| additional information | - |
additional information | - |
Tequatrovirus T4 | |
| additional information | - |
additional information | - |
Equus asinus | |
| additional information | - |
additional information | - |
Escherichia phage T2 |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20000 | - |
6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dCMP + H2O | Gallus gallus | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Bacillus subtilis | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Homo sapiens | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Rattus norvegicus | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Saccharomyces cerevisiae | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Tequatrovirus T4 | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Echinoidea | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Equus asinus | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Herpes simplex virus | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Escherichia phage T2 | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Betapolyomavirus macacae | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Enterobacteria phage T6 | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Polyomavirus sp. | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | dUMP + NH3 | - |
? | |
| dCMP + H2O | Gallus gallus | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Bacillus subtilis | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Homo sapiens | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Rattus norvegicus | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Saccharomyces cerevisiae | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Tequatrovirus T4 | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Echinoidea | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Equus asinus | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Herpes simplex virus | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Escherichia phage T2 | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Betapolyomavirus macacae | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Enterobacteria phage T6 | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| dCMP + H2O | Polyomavirus sp. | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | dUMP + NH3 | - |
? | |
| additional information | Homo sapiens | - |
? | - |
? | |
| additional information | Tequatrovirus T4 | function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Betapolyomavirus macacae | - |
induced by | - |
| Echinoidea | - |
- |
- |
| Enterobacteria phage T6 | - |
T2-, T4-, and T6-phage induced enzyme in Escherichia coli | - |
| Equus asinus | - |
donkey | - |
| Escherichia phage T2 | - |
T2-, T4-, and T6-phage induced enzyme in Escherichia coli | - |
| Escherichia phage T2 | - |
T2-phage infected Escherichia coli | - |
| Escherichia phage T2 | - |
T2r+-infected Escherichia coli B | - |
| Gallus gallus | - |
- |
- |
| Herpes simplex virus | - |
induced by | - |
| Homo sapiens | - |
human | - |
| no activity in Escherichia coli | - |
enzyme not detectable in Escherichia coli until after infection with T-even bacteriophage | - |
| no activity in Escherichia coli | - |
wild type Escherichia coli contains no dCMP deaminase | - |
| no activity in Salmonella typhimurium | - |
do not contain dCMP deaminase | - |
| Polyomavirus sp. | - |
induced by | - |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Tequatrovirus T4 | - |
T2-, T4-, and T6-phage induced enzyme in Escherichia coli | - |
| Tequatrovirus T4 | - |
T4-phage infected Escherichia coli | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
| HeLa cells | Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Gallus gallus | |
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Bacillus subtilis | |
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Homo sapiens | |
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Rattus norvegicus | |
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Tequatrovirus T4 | |
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Equus asinus | |
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Escherichia phage T2 | |
| dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Enterobacteria phage T6 | |
| dCMP + H2O = dUMP + NH3 | feedback regulation | Gallus gallus | |
| dCMP + H2O = dUMP + NH3 | feedback regulation | Homo sapiens | |
| dCMP + H2O = dUMP + NH3 | feedback regulation | Rattus norvegicus | |
| dCMP + H2O = dUMP + NH3 | feedback regulation | Tequatrovirus T4 | |
| dCMP + H2O = dUMP + NH3 | feedback regulation | Equus asinus | |
| dCMP + H2O = dUMP + NH3 | feedback regulation | Escherichia phage T2 | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Gallus gallus | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Bacillus subtilis | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Homo sapiens | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Rattus norvegicus | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Tequatrovirus T4 | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Equus asinus | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Escherichia phage T2 | |
| dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Enterobacteria phage T6 |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Echinoidea | - |
| embryo | - |
Gallus gallus | - |
| embryo | - |
Rattus norvegicus | - |
| HeLa cell | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| additional information | associated mainly with dividing tissues | Gallus gallus | - |
| additional information | associated mainly with dividing tissues | Bacillus subtilis | - |
| additional information | associated mainly with dividing tissues | Homo sapiens | - |
| additional information | associated mainly with dividing tissues | Rattus norvegicus | - |
| additional information | associated mainly with dividing tissues | Saccharomyces cerevisiae | - |
| additional information | associated mainly with dividing tissues | Tequatrovirus T4 | - |
| additional information | associated mainly with dividing tissues | Echinoidea | - |
| additional information | associated mainly with dividing tissues | Equus asinus | - |
| additional information | associated mainly with dividing tissues | Herpes simplex virus | - |
| additional information | associated mainly with dividing tissues | Escherichia phage T2 | - |
| additional information | associated mainly with dividing tissues | Betapolyomavirus macacae | - |
| additional information | associated mainly with dividing tissues | Enterobacteria phage T6 | - |
| additional information | associated mainly with dividing tissues | Polyomavirus sp. | - |
| spleen | - |
Homo sapiens | - |
| spleen | - |
Equus asinus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 500 | - |
HeLa cells | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-bromo-dCMP + H2O | - |
Saccharomyces cerevisiae | 5-bromo-dUMP + NH3 | - |
? | |
| 5-bromo-dCMP + H2O | - |
Equus asinus | 5-bromo-dUMP + NH3 | - |
? | |
| 5-bromo-dCMP + H2O | - |
Escherichia phage T2 | 5-bromo-dUMP + NH3 | - |
? | |
| 5-bromo-dCMP + H2O | very good substrate | Gallus gallus | 5-bromo-dUMP + NH3 | - |
? | |
| 5-fluoro-dCMP + H2O | - |
Saccharomyces cerevisiae | 5-fluoro-dUMP + NH3 | - |
? | |
| 5-fluoro-dCMP + H2O | - |
Equus asinus | 5-fluoro-dUMP + NH3 | - |
? | |
| 5-fluoro-dCMP + H2O | very good substrate | Gallus gallus | 5-fluoro-dUMP + NH3 | - |
? | |
| 5-fluoro-dCMP + H2O | very good substrate | Escherichia phage T2 | 5-fluoro-dUMP + NH3 | - |
? | |
| 5-Hg-dCMP + H2O | deamination activated by dTTP and inhibited by dCTP | Homo sapiens | 5-Hg-dUMP + NH3 | - |
? | |
| 5-Hg-dCMP + H2O | deamination activated by dTTP and inhibited by dCTP | Equus asinus | 5-Hg-dUMP + NH3 | - |
? | |
| 5-hydroxymethyl-dCMP + H2O | - |
Gallus gallus | 5-hydroxymethyl-dUMP + NH3 | - |
? | |
| 5-hydroxymethyl-dCMP + H2O | - |
Tequatrovirus T4 | 5-hydroxymethyl-dUMP + NH3 | - |
? | |
| 5-hydroxymethyl-dCMP + H2O | - |
Equus asinus | 5-hydroxymethyl-dUMP + NH3 | - |
? | |
| 5-hydroxymethyl-dCMP + H2O | HeLa cells, good substrate | Homo sapiens | 5-hydroxymethyl-dUMP + NH3 | - |
? | |
| 5-iodo-dCMP + H2O | - |
Gallus gallus | 5-iodo-dUMP + NH3 | - |
? | |
| 5-iodo-dCMP + H2O | - |
Equus asinus | 5-iodo-dUMP + NH3 | - |
? | |
| 5-iodo-dCMP + H2O | very poor substrate | Saccharomyces cerevisiae | 5-iodo-dUMP + NH3 | - |
? | |
| 5-iodo-dCMP + H2O | very poor substrate | Escherichia phage T2 | 5-iodo-dUMP + NH3 | - |
? | |
| 5-methyl-dCMP + H2O | - |
Homo sapiens | 5-methyl-dUMP + NH3 | - |
? | |
| 5-methyl-dCMP + H2O | - |
Saccharomyces cerevisiae | 5-methyl-dUMP + NH3 | - |
? | |
| 5-methyl-dCMP + H2O | - |
Equus asinus | 5-methyl-dUMP + NH3 | - |
? | |
| 5-methyl-dCMP + H2O | very good substrate | Gallus gallus | 5-methyl-dUMP + NH3 | - |
? | |
| 5-methyl-dCMP + H2O | very good substrate | Escherichia phage T2 | 5-methyl-dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Gallus gallus | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Bacillus subtilis | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Homo sapiens | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Rattus norvegicus | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Saccharomyces cerevisiae | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Tequatrovirus T4 | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Echinoidea | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Equus asinus | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Herpes simplex virus | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Escherichia phage T2 | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Betapolyomavirus macacae | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Enterobacteria phage T6 | dUMP + NH3 | - |
? | |
| dCMP + H2O | - |
Polyomavirus sp. | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Gallus gallus | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Bacillus subtilis | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Homo sapiens | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Rattus norvegicus | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Saccharomyces cerevisiae | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Tequatrovirus T4 | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Echinoidea | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Equus asinus | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Herpes simplex virus | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Escherichia phage T2 | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Betapolyomavirus macacae | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Enterobacteria phage T6 | dUMP + NH3 | - |
? | |
| dCMP + H2O | providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA | Polyomavirus sp. | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Gallus gallus | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Bacillus subtilis | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Homo sapiens | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Rattus norvegicus | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Saccharomyces cerevisiae | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Tequatrovirus T4 | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Echinoidea | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Equus asinus | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Herpes simplex virus | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Escherichia phage T2 | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Betapolyomavirus macacae | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Enterobacteria phage T6 | dUMP + NH3 | - |
? | |
| dCMP + H2O | importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides | Polyomavirus sp. | dUMP + NH3 | - |
? | |
| additional information | - |
Homo sapiens | ? | - |
? | |
| additional information | substrate specificity | Gallus gallus | ? | - |
? | |
| additional information | substrate specificity | Bacillus subtilis | ? | - |
? | |
| additional information | substrate specificity | Homo sapiens | ? | - |
? | |
| additional information | substrate specificity | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | substrate specificity | Equus asinus | ? | - |
? | |
| additional information | substrate specificity | Escherichia phage T2 | ? | - |
? | |
| additional information | function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants | Tequatrovirus T4 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 identical subunits | Gallus gallus |
| hexamer | 6 identical subunits | Homo sapiens |
| hexamer | 6 identical subunits | Rattus norvegicus |
| hexamer | 6 identical subunits | Tequatrovirus T4 |
| hexamer | 6 identical subunits | Equus asinus |
| hexamer | 6 identical subunits | Escherichia phage T2 |
| hexamer | 6 identical subunits | Enterobacteria phage T6 |
| hexamer | 6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Tequatrovirus T4 |
| 30 | - |
optimum condition | Homo sapiens |
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