3.5.4.12: dCMP deaminase This is an abbreviated version! For detailed information about dCMP deaminase, go to the full flat file .
Reaction
dCMP +
H2O =
dUMP +
NH3
Synonyms 2-deoxycytidylate deaminase, 5-mdCMP deaminase, 5-methyldeoxycytidine monophosphate deaminase, DCD, DCD1, dCDA, dCMP deaminase, dCMP-aminohydrolase, dCMP-dCTP deaminase, dCMPase, dCMPD, deaminase, deoxycytidylate, deoxy-CMP-deaminase, deoxycytidine deaminase, deoxycytidine monophosphate deaminase, deoxycytidine nucleotide deaminase, deoxycytidine-5'-monophosphate aminohydrolase, deoxycytidine-5'-monophosphate deaminase, deoxycytidine-5'-phosphate deaminase, deoxycytidylate aminohydrolase, deoxycytidylate deaminase, ST2 protein, STRIPE2, T2-dCMP deaminase, T2-deoxycytidylate deaminase, T2-phage deoxycytidylate deaminase, T4-dCMP deaminase, T4-deaminase, T4-phage deoxycytidylate deaminase
ECTree
Application
Application on EC 3.5.4.12 - dCMP deaminase
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medicine
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associated mainly with dividing tissues, potential diagnostic tool for various disease states in which enzyme is elevated
medicine
Tequatrovirus T4
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the enzyme is a major target for cancer chemotherapy
pharmacology
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elevated level of dCMPase in transformed cells and tumors: enzyme may represent another important target for cancer chemotherapy
pharmacology
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might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents
pharmacology
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enzyme might be a reasonable target for chemotherapeutic agents directed against parasitic as well as neoplastic diseases by limiting the synthesis of dUMP, particularly when used in combination with inhibitors of dTMP synthase or other purine and pyrimidine inhibitors of DNA synthesis