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3.5.1.1: asparaginase

This is an abbreviated version!
For detailed information about asparaginase, go to the full flat file.

Word Map on EC 3.5.1.1

Reaction

L-asparagine
+
H2O
=
L-aspartate
 +
NH3

Synonyms

14270 ASNase, alpha-asparaginase, AnsA, ansA3, AnsB, ansZ, Asn, ASNase, ASNase1, ASNase3, ASP1, ASP3, asparaginase, asparaginase II, asparagine amidohydrolase, asparginase II, ASPG, ASPG II, ASPGA1, ASPGB1, ASRGL1, At3g16150, colaspase, crasnitin, DiAsp, EcAII, EcAIII, EcaL-ASNase, ECAR-LANS, elspar, ErA, Erwinase, glutaminase-free L-asparaginase, glutamine-(asparagin-)ase, HPA, L-ASNase, L-asparaginase, L-asparaginase 2, L-asparaginase I, L-asparaginase II, L-asparaginase III, L-asparaginase type II, L-asparaginase type III, L-asparaginase-I, L-asparaginase-II, L-asparagine amidohydrolase, L-asparagine amino hydrolase, L-asparagine aminohydrolase, leunase, PfA, PhA, potassium-dependent asparaginase, potassium-independent asparaginase, potassium-independent L-asparaginase, SAMN05216263_10744, SGR ASNase, type I L-asparaginase, type II L-asparaginase, Ypa

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.1 asparaginase

Activating Compound

Activating Compound on EC 3.5.1.1 - asparaginase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-amino-6-methyl-4-phenyl-2-thioxy-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester
-
enhances activity
2-mercaptoethanol
albumin
-
0.1 mg/ml, 3fold activation of L-asparaginase II
-
bovine serum albumin
-
slightly enhances activity
-
citrate
-
stimulates
dithiothreitol
glutathione
-
enhances activity
glycine
L-Cys
L-cysteine
-
activates 148% at 1 mM
L-cystine
-
causes an increase in Vmax value and a decrease in Km value, nonessential mode of activation
L-His
L-histidine
-
activates 148% at 1 mM
L-methionine
-
causes an increase in Vmax value and a decrease in Km value, nonessential mode of activation
Lipid
-
activates
liquid paraffin
-
6% (v/v) results in 34% increase in the L-asparaginase activity accompanied by a 48% increase in the production of cell mass at a 10 l scale
-
N-acetyl-L-cysteine
-
causes an increase in Vmax value and a decrease in Km value, nonessential mode of activation
n-dodecane
-
exhibit a stimulatory effect in L-asparaginase activity, ca. 104% compared to control
PCMB
-
slight stimulation
potassium iodide
231.68% activity at 1 mM
SDS
-
78% inhibition at 3.0 mM, 119% activation at 2.0 mM
silicone oil
-
exhibit a stimulatory effect in L-asparaginase activity, ca. 108% compared to control
-
sorbitol
-
30% w/v, activates more than 10fold
Tartrate
-
stimulation
Triton X-100
161.26% activity at 1% (v/v)
Tween-80
123.45% activity at 1% (v/v)
additional information
-