Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.5.1.1: asparaginase

This is an abbreviated version!
For detailed information about asparaginase, go to the full flat file.

Word Map on EC 3.5.1.1

Reaction

L-asparagine
+
H2O
=
L-aspartate
 +
NH3

Synonyms

14270 ASNase, alpha-asparaginase, AnsA, ansA3, AnsB, ansZ, Asn, ASNase, ASNase1, ASNase3, ASP1, ASP3, asparaginase, asparaginase II, asparagine amidohydrolase, asparginase II, ASPG, ASPG II, ASPGA1, ASPGB1, ASRGL1, At3g16150, colaspase, crasnitin, DiAsp, EcAII, EcAIII, EcaL-ASNase, ECAR-LANS, elspar, ErA, Erwinase, glutaminase-free L-asparaginase, glutamine-(asparagin-)ase, HPA, L-ASNase, L-asparaginase, L-asparaginase 2, L-asparaginase I, L-asparaginase II, L-asparaginase III, L-asparaginase type II, L-asparaginase type III, L-asparaginase-I, L-asparaginase-II, L-asparagine amidohydrolase, L-asparagine amino hydrolase, L-asparagine aminohydrolase, leunase, PfA, PhA, potassium-dependent asparaginase, potassium-independent asparaginase, potassium-independent L-asparaginase, SAMN05216263_10744, SGR ASNase, type I L-asparaginase, type II L-asparaginase, Ypa

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.1 asparaginase

Substrates Products

Substrates Products on EC 3.5.1.1 - asparaginase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acrylamide + H2O
acrylic acid + NH3
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Asn + H2O
benzyloxycarbonyl-Gly-L-Asp
show the reaction diagram
-
-
-
?
beta-Asp-His + H2O
?
show the reaction diagram
-
substrate of ASPGA1 and ASPGB1, ASPGA1 has a 4fold substrate preference for beta-Asp-His over Asn
-
-
?
beta-aspartoethylamide + H2O
?
show the reaction diagram
-
at 0.4% of the activity with L-Asn
-
-
?
beta-aspartomethylamide + H2O
L-Asp + ethylamine
show the reaction diagram
-
at 0.5% of the activity with L-Asn
-
-
?
beta-aspartopropylamide + H2O
?
show the reaction diagram
-
at 0.7% of the activity with L-Asn
-
-
?
beta-cyano-L-Ala + H2O
?
show the reaction diagram
beta-L-Asp-L-Phe + H2O
?
show the reaction diagram
D-Asn + H2O
D-Asp + NH3
show the reaction diagram
D-asparagine + H2O
D-aspartate + NH3
show the reaction diagram
D-aspartic acid beta-hydroxamate + H2O
D-Asp + hydroxylamine
show the reaction diagram
-
59% of the activity with L-Asn
-
-
?
D-glutamine + H2O
D-glutamate + NH3
show the reaction diagram
diazo-4-oxo-L-norvaline + H2O
5-hydroxy-4-oxo-L-norvaline + NH3
show the reaction diagram
-
-
-
?
DL-Ala-DL-Asn + H2O
DL-Ala-DL-Asn + DL-Ala-DL-Asp
show the reaction diagram
-
-
75% Ala-Asp + 25% Ala-Asn
?
DL-aspartyl hydroxamate + H2O
DL-Asp + hydroxylamine
show the reaction diagram
Gly-D-Asn + H2O
Gly-D-Asp + NH3
show the reaction diagram
-
-
-
?
Gly-L-Asn + H2O
Gly-L-Asp + NH3
show the reaction diagram
-
-
-
?
L-Asn + H2O
?
show the reaction diagram
-
-
-
-
?
L-Asn + H2O
L-Asp + NH3
show the reaction diagram
L-Asp + H2O
?
show the reaction diagram
-
-
-
-
?
L-asparagine + H2O
?
show the reaction diagram
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
show the reaction diagram
L-asparagine + H2O
L-aspartic acid + NH3
show the reaction diagram
L-aspartic acid + NH3
?
show the reaction diagram
L-aspartic acid beta-hydrazide + H2O
L-Asp + hydroxylamine
show the reaction diagram
-
2% of the activity with L-Asn
-
-
?
L-aspartic acid beta-hydroxamate + H2O
L-Asp + hydroxylamine
show the reaction diagram
L-aspartyl hydroxamate + H2O
L-aspartate + hydroxylamine
show the reaction diagram
L-aspartyl-beta-hydroxamate + H2O
L-Asp + hydroxylamine
show the reaction diagram
L-Gln + H2O
?
show the reaction diagram
-
-
-
-
?
L-Gln + H2O
L-Glu + NH3
show the reaction diagram
L-Gln-L-Asn + H2O
L-Gln-L-Asp + NH3
show the reaction diagram
-
-
-
?
L-Glu-L-Asn + H2O
L-Glu-L-Asp + NH3
show the reaction diagram
-
-
-
?
L-glutamic acid gamma-hydroxamate + H2O
L-Glu + hydroxylamine
show the reaction diagram
-
1% of the activity with L-Asn
-
-
?
L-glutamine + H2O
?
show the reaction diagram
L-glutamine + H2O
L-glutamate + NH3
show the reaction diagram
L-glutamine + H2O
L-glutamic acid + NH3
show the reaction diagram
L-glutamyl hydroxamate + H2O
L-glutamate + hydroxylamine
show the reaction diagram
-
16% relative activity compared to L-asparagine as substrate
-
-
?
L-leucine amide + H2O
?
show the reaction diagram
-
5.3% of the activity with L-Asn
-
-
?
L-phenylalanine amide + H2O
?
show the reaction diagram
-
8.2% of the activity with L-Asn
-
-
?
N-acetyl-L-asparagine + H2O
N-acetyl-L-aspartic acid + NH3
show the reaction diagram
-
-
-
?
N4-ethyl-L-asparagine
L-Asp + propylamine
show the reaction diagram
-
12% of the activity with L-Asn
-
-
?
N4-methoxy-L-asparagine + H2O
L-Asp + O-methylhydroxylamine
show the reaction diagram
-
154% of the activity with L-Asn
-
-
?
N4-methyl-L-asparagine
L-Asp + methylamine
show the reaction diagram
-
12% of the activity with L-Asn
-
-
?
Nalpha-acetyl-L-Asn + H2O
Nalpha-acetyl-L-Asp + NH3
show the reaction diagram
Nalpha-acetyl-L-asparagine + H2O
Nalpha-acetyl-L-aspartate + NH3
show the reaction diagram
-
-
-
-
?
Nalpha-methyl-L-Asn + H2O
Nalpha-methyl-L-Asp + NH3
show the reaction diagram
-
26% of the activity with L-Asn
-
-
?
poly-L-asparagine + H2O
?
show the reaction diagram
succinamic acid + H2O
?
show the reaction diagram
-
at 20% of the activity with L-Asn
-
-
?
succinamic acid + H2O
succinate + NH3
show the reaction diagram
threo-3-hydroxy-L-asparagine + H2O
?
show the reaction diagram
-
36% of the activity with L-Asn
-
-
?
urea + H2O
? + NH3
show the reaction diagram
-
-
-
-
?
additional information
?
-