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3.5.1.1: asparaginase

This is an abbreviated version!
For detailed information about asparaginase, go to the full flat file.

Word Map on EC 3.5.1.1

Reaction

L-asparagine
+
H2O
=
L-aspartate
 +
NH3

Synonyms

14270 ASNase, alpha-asparaginase, AnsA, ansA3, AnsB, ansZ, Asn, ASNase, ASNase1, ASNase3, ASP1, ASP3, asparaginase, asparaginase II, asparagine amidohydrolase, asparginase II, ASPG, ASPG II, ASPGA1, ASPGB1, ASRGL1, At3g16150, colaspase, crasnitin, DiAsp, EcAII, EcAIII, EcaL-ASNase, ECAR-LANS, elspar, ErA, Erwinase, glutaminase-free L-asparaginase, glutamine-(asparagin-)ase, HPA, L-ASNase, L-asparaginase, L-asparaginase 2, L-asparaginase I, L-asparaginase II, L-asparaginase III, L-asparaginase type II, L-asparaginase type III, L-asparaginase-I, L-asparaginase-II, L-asparagine amidohydrolase, L-asparagine amino hydrolase, L-asparagine aminohydrolase, leunase, PfA, PhA, potassium-dependent asparaginase, potassium-independent asparaginase, potassium-independent L-asparaginase, SAMN05216263_10744, SGR ASNase, type I L-asparaginase, type II L-asparaginase, Ypa

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.1 asparaginase

Inhibitors

Inhibitors on EC 3.5.1.1 - asparaginase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-amino-5-chloro-4-oxo pentanoic acid
-
-
2-mercaptoethanol
3-Cyano-L-Ala
4-chloromercuribenzoate
-
complete inhibition at 0.5 mM
4-methylene-L-glutamine
-
-
4-phenylbutanoic acid
-
more than 80% residual activity at 10 mM
5-Bromo-4-oxo-L-norvaline
-
-
5-Diazo-4-oxo-L-norvaline
6-diazo-5-oxo-L-norleucine
-
-
aspartic acid
beta-aspartyl hydroxamate
48% inhibition at 5 mM
Bromoacetic acid
-
-
cyclo-(Pro-Phe)
21% inhibition at 0.02 mM
cyclo-(Pro-Tyr)
21% inhibition at 0.002 mM
cysteine
D-Asn
D-asparagine
39% inhibition at 5 mM
Dichromate
-
-
diethyldicarbonate
-
-
Dimethylsulfoxide
-
-
dithiothreitol
DL-aspartate 3-hydroxamate
-
-
DL-aspartyl hydroxamate
-
-
ethylenediamine
-
weak
Glutaraldehyde
-
inhibits the enzyme during immobilization at concentrations above 0.2%
Gly methyl ester
-
-
Gly-Gly
-
-
H2O2
-
76% inhibition at 1.0 mM
hydroxylamine
-
-
iodoacetamide
iodoacetate
-
-
L-Asn
-
inhibits hydrolysis of diazo-4-oxo-L-norvaline
L-Asp
L-asparagine
-
substrate inhibition above 20 mM L-asparagine
Lactate
-
about 70% inhibition at 10 mM
Li+
KC573069
10 mM, 17% residual activity
N-bromosuccinimide
-
1 mM, 5% inhibition
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinline
-
no effect up to 1 mM: Mg2+, Mn2+ and Ca2+
N4-hydroxyethyl-L-asparagine
-
-
O-(diazoacetyl)-L-serine
-
-
oxylate
-
about 70% inhibition at 10 mM
p-chloromercuribenzoate
p-chloromercuribenzoic acid
-
-
p-hydroxymercuribenzoate
p-mercuribenzoate
-
-
Phenylglyoxal
-
protection by substrate
phenylmethylsulfonyl fluoride
-
more than 80% residual activity at 10 mM
Phospholipase C
-
-
-
potassium ferricyanide
-
-
pyruvate
Sodium azide
-
1 mM, 15% inhibition
Succinamide
-
weak
Thiourea
1 mM, about 85% residual activtiy
Triton X-100
-
-
Trypsin
-
the free enzyme is completely inactivated by trypsin within 10 min, while the immobilized enzyme is stable for 240 min with loss of 30% activity
-
additional information
-