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3.5.1.1: asparaginase

This is an abbreviated version!
For detailed information about asparaginase, go to the full flat file.

Word Map on EC 3.5.1.1

Reaction

L-asparagine
+
H2O
=
L-aspartate
 +
NH3

Synonyms

14270 ASNase, alpha-asparaginase, AnsA, ansA3, AnsB, ansZ, Asn, ASNase, ASNase1, ASNase3, ASP1, ASP3, asparaginase, asparaginase II, asparagine amidohydrolase, asparginase II, ASPG, ASPG II, ASPGA1, ASPGB1, ASRGL1, At3g16150, colaspase, crasnitin, DiAsp, EcAII, EcAIII, EcaL-ASNase, ECAR-LANS, elspar, ErA, Erwinase, glutaminase-free L-asparaginase, glutamine-(asparagin-)ase, HPA, L-ASNase, L-asparaginase, L-asparaginase 2, L-asparaginase I, L-asparaginase II, L-asparaginase III, L-asparaginase type II, L-asparaginase type III, L-asparaginase-I, L-asparaginase-II, L-asparagine amidohydrolase, L-asparagine amino hydrolase, L-asparagine aminohydrolase, leunase, PfA, PhA, potassium-dependent asparaginase, potassium-independent asparaginase, potassium-independent L-asparaginase, SAMN05216263_10744, SGR ASNase, type I L-asparaginase, type II L-asparaginase, Ypa

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.1 asparaginase

Metals Ions

Metals Ions on EC 3.5.1.1 - asparaginase

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CN-
-
enhances activity
diphosphate
-
stimulation
EDTA
-
inhibits enzyme, 1, 3, and 10 mM tested
Fe2+
about 203.7% activity at 10 mM
HPO42-
-
stimulation
I-
-
enhances activity
K3Fe(CN)6
-
stimulation
KCl
the catalytic activity of YpA does not vary significantly as a function of ionic strength at 100-3000 mM KCl
KI
-
stimulates activity
Li+
-
rapid and reversible activation
Ni2+
-
5 mM, 37°C, 136% relative activity compared to the activity in absence of metal cations
Pb2+
-
stimulates activity
PO43-
-
enhances activity
Rb+
monovalent cation preference in order of decreasing efficiency is: K+, Na+, Rb+
Triton X-100
-
2 mM, 114% of initial activity
additional information