3.5.1.1: asparaginase
This is an abbreviated version!
For detailed information about asparaginase, go to the full flat file.
Word Map on EC 3.5.1.1
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3.5.1.1
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leukemia
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lymphoblastic
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children
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remission
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erwinia
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hypersensitivity
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methotrexate
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lymphoma
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vincristine
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pegylated
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relapse
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pancreatitis
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thrombosis
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prednisone
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high-dose
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venous
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oncology
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event-free
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schedule
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cytarabine
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consolidation
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intensification
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antileukemic
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intrathecal
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antithrombin
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l-aspartic
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chrysanthemi
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anthracyclines
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medicine
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reinduction
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cyclophosphamide
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pegaspargase
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thromboembolism
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allergy
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acrylamide
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arabinoside
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mercaptopurine
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daunorubicin
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osteonecrosis
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analysis
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philadelphia
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extranodal
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fried
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b-precursor
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succinogenes
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standard-risk
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synthesis
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coli-derived
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food industry
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diagnostics
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biotechnology
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dana-farber
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pharmacology
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teniposide
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carotovora
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multiagent
- 3.5.1.1
- leukemia
- lymphoblastic
- children
-
remission
- erwinia
- hypersensitivity
- methotrexate
- lymphoma
- vincristine
-
pegylated
-
relapse
- pancreatitis
- thrombosis
- prednisone
-
high-dose
- venous
-
oncology
-
event-free
-
schedule
- cytarabine
-
consolidation
-
intensification
-
antileukemic
-
intrathecal
- antithrombin
-
l-aspartic
- chrysanthemi
- anthracyclines
- medicine
-
reinduction
- cyclophosphamide
-
pegaspargase
- thromboembolism
- allergy
- acrylamide
-
arabinoside
- mercaptopurine
- daunorubicin
- osteonecrosis
- analysis
-
philadelphia
-
extranodal
-
fried
-
b-precursor
- succinogenes
-
standard-risk
- synthesis
-
coli-derived
- food industry
- diagnostics
- biotechnology
-
dana-farber
- pharmacology
- teniposide
- carotovora
-
multiagent
Reaction
Synonyms
14270 ASNase, alpha-asparaginase, AnsA, ansA3, AnsB, ansZ, Asn, ASNase, ASNase1, ASNase3, ASP1, ASP3, asparaginase, asparaginase II, asparagine amidohydrolase, asparginase II, ASPG, ASPG II, ASPGA1, ASPGB1, ASRGL1, At3g16150, colaspase, crasnitin, DiAsp, EcAII, EcAIII, EcaL-ASNase, ECAR-LANS, elspar, ErA, Erwinase, glutaminase-free L-asparaginase, glutamine-(asparagin-)ase, HPA, L-ASNase, L-asparaginase, L-asparaginase 2, L-asparaginase I, L-asparaginase II, L-asparaginase III, L-asparaginase type II, L-asparaginase type III, L-asparaginase-I, L-asparaginase-II, L-asparagine amidohydrolase, L-asparagine amino hydrolase, L-asparagine aminohydrolase, leunase, PfA, PhA, potassium-dependent asparaginase, potassium-independent asparaginase, potassium-independent L-asparaginase, SAMN05216263_10744, SGR ASNase, type I L-asparaginase, type II L-asparaginase, Ypa
ECTree
3.5.1.1 asparaginaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.5.1.1 - asparaginase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
activity is highest in sink tissues, especially in flowers and siliques
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sediment samples obtained from Tamilnadu and Kerala in India, production of the enzyme in three different media, solid-State media, tryptone glucose yeast extract, and tryptone fructose yeast extract broth. 10 isolates (S1, S2, S3, S4, S5, S6, S8. K2, K4, K5, and K8), only S3, S4 and K8 show L-asparaginase activity
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activity in all tested varieties is significantly higher in roots than in spears and leaves
additional information
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solid state, production evaluation and optimization of culture conditions using factorial designs
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solid state, production evaluation and optimization of culture conditions using factorial designs
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optimal conditions of induction are: inductor concentration of 0.1-0.2%, its addition during the middle of the logphase at 1.45-2.3 OU600, and culturing temperature of 28°C. The optimal duration of culturing after induction is 7-16 h
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optimal conditions of induction are: inductor concentration of 0.1-0.2%, its addition during the middle of the logphase at 1.45-2.3 OU600, and culturing temperature of 28°C. The optimal duration of culturing after induction is 7-16 h
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optimization of production of L-asparaginase by strain MK-VL_113. Optimal production at pH 7.0 and 30°C in a 72 h old culture in modified ISP-5 medium containing yeast extract, tryptone, or L-asparagine at 1-1.5% w/v as nitrogen source and 2% glycerol as carbon source, overview
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optimization of production of L-asparaginase by strain MK-VL_113. Optimal production at pH 7.0 and 30°C in a 72 h old culture in modified ISP-5 medium containing yeast extract, tryptone, or L-asparagine at 1-1.5% w/v as nitrogen source and 2% glycerol as carbon source, overview
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high L-asparaginase activity is found in cells cultured on L-fructose, D-galactose, sucrose or maltose, and in cells cultured on L-asparagine as the sole nitrogen source
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sabourand dextrose broth yields maximum growth and maximum L-asparaginase production
L-asparaginase-II is secreted in response to N starvation
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carbon sources such as sucrose, maltose, galactose, lactose, mannitol and mannose inhibit enzyme production. Exogenous cAMP in presence of carbon sources stimulates L-asparaginase enzyme production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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study of the effect of various carbon sources on pH of the broth and L-asparaginase production
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activity in all tested varieties is significantly higher in roots than in spears and leaves
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activity in all tested varieties is significantly higher in roots than in spears and leaves
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germinating and non-germinating seeds are studied, highest specific activity in germinating seeds in all cultivars
additional information
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comprehensive comparison shows that the Asparagus officinalis A7 variety has the highest asparaginase activity, while A1 has the lowest, regardless of the tissue type
additional information
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production of high levels of L-asparaginase in solid state fermentation, using agro-wastes from three leguminous crops (bran of Cajanus cajan, Phaseolus mungo, and Glycine max)
additional information
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highest L-asparaginase production in 2% proline medium, the lowest L-asparaginase production levels is found in the presence of glutamine and urea as nitrogen sources
additional information
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the lowest L-asparaginase production levels is found in the presence of glutamine and urea as nitrogen sources
additional information
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the synthesis of L-asparaginase in Escherichia coli W and Escherichia coli K-12 is almost completely suppressed if glucose is added at a concentration of 0.5% to the growth medium. Organic acids and amino acids such as L-leucine and L-methionine enhance production of L-asparaginase. n-Dodecane at 6% increases cell concentration by 12.7% and production of L-asparaginase by 21% to give 60.8 IU/ml in the fermentation medium
additional information
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a pH of 7.9, casein hydrolysate (3.11%) and corn-steep liquor (3.68%) are the most significant factors improving the enzyme production process
additional information
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a pH of 7.9, casein hydrolysate (3.11%) and corn-steep liquor (3.68%) are the most significant factors improving the enzyme production process
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additional information
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enzyme activity is highest during the exponential phase of growth
additional information
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incubation temperature, inoculum level and medium pH, among all fermentation factors, are major influential parameters at their individual level, and contributed to more than 60% of total L-asparaginase production
additional information
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incubation temperature, inoculum level and medium pH, among all fermentation factors, are major influential parameters at their individual level, and contributed to more than 60% of total L-asparaginase production
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additional information
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isolated from laterite soil samples of Guntar region
