3.4.22.35: Histolysain
This is an abbreviated version!
For detailed information about Histolysain, go to the full flat file.
Word Map on EC 3.4.22.35
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3.4.22.35
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cathepsins
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lysosomal
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cystatins
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papain
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calpains
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trypanosoma
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plasmodium
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falciparum
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papain-like
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cruzi
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resorption
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polyproteins
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antimalarial
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allergen
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caspase-1
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pyogenes
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chagas
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mite
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propeptide
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calcium-dependent
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osteoclast
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leupeptin
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trophozoite
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m-calpain
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asparaginyl
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proenzyme
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cruzipain
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warhead
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nsp2
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calpain-mediated
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hexakisphosphate
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pteronyssinus
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pyrogenic
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procathepsin
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cpp32
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streptococcal
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metacercariae
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3clpro
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autoprocessing
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bromelain
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kininogens
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calpastatin
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pineapple
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gingipains
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l-like
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alln
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osteoclast-mediated
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legumain
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collagenolytic
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dermatophagoides
- 3.4.22.35
- cathepsins
- lysosomal
- cystatins
- papain
- calpains
- trypanosoma
- plasmodium
- falciparum
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papain-like
- cruzi
- resorption
- polyproteins
-
antimalarial
- allergen
- caspase-1
- pyogenes
- chagas
- mite
- propeptide
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calcium-dependent
- osteoclast
- leupeptin
- trophozoite
- m-calpain
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asparaginyl
- proenzyme
- cruzipain
-
warhead
- nsp2
-
calpain-mediated
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hexakisphosphate
- pteronyssinus
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pyrogenic
-
procathepsin
- cpp32
- streptococcal
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metacercariae
- 3clpro
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autoprocessing
- bromelain
- kininogens
- calpastatin
- pineapple
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gingipains
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l-like
- alln
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osteoclast-mediated
- legumain
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collagenolytic
- dermatophagoides
Reaction
hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec =
Synonyms
Amebapain, amoebapain, CP1, CP2, CP5, CP6, cysteine protease, cysteine protease 1, cysteine protease 2, cysteine protease 5, cysteine protease 6, cysteine proteinase 1, cysteine proteinase 5, EhCP1, EhCP112, EhCP2, EhCP5, Entamoeba histolytica 112kDa adhesin, Entamoeba histolytica cysteine protease, Entamoeba histolytica cysteine proteinase, Entamoeba histolytica cysteine proteinase 5, Entamoeba histolytica cysteine-proteinase, Entamoeba histolytica neutral thiol proteinase, Histolysin, More, PCP5, ppEhCP-B9, Proteinase, Entamoeba histolytica cysteine
ECTree
3.4.22.35 HistolysainAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.35 - Histolysain
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
chemokine CCL13 + H2O
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Entamoeba histolytica is a human pathogen causing amoebic colitis, the enzyme is involved in the inflammation process modulating human host leucocyte migration by proteolytic cleavage of chemokines CCL2, CCL13, and CXCL8, a mechanism to circumvent host immune response
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chemokine CCL2 + H2O
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Entamoeba histolytica is a human pathogen causing amoebic colitis, the enzyme is involved in the inflammation process modulating human host leucocyte migration by proteolytic cleavage of chemokines CCL2, CCL13, and CXCL8, a mechanism to circumvent host immune response
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chemokine CXCL8 + H2O
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Entamoeba histolytica is a human pathogen causing amoebic colitis, the enzyme is involved in the inflammation process modulating human host leucocyte migration by proteolytic cleavage of chemokines CCL2, CCL13, and CXCL8, a mechanism to circumvent host immune response
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MUC2 mucin + H2O
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disruption of the protective mucin layer of targeted host cells, entry mechanism of the pathogen, overview
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mucin MUC2 polymer + H2O
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enzyme is involved, together with other Entamoeba histolytica cysteine proteinases, in the degradation of mucin in the mucous layer of the colon epithelium, altering the protective function to facilitate parasite attachment
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?
protein + H2O
peptides
enzyme is involved in pathogenic destruction of host tissue by degradation of extracellular matrix proteins
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?
additional information
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appears to be important both for digestion and as a cytotoxic factor
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additional information
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the enzyme can degrade colon cell mucin and destroy epithelial cell layers
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additional information
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the enzyme degrades a number of proteins, including those of the extracellular matrix
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additional information
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the enzyme is involved in host tissue invasion by trophozoites and destroys cell monolayers
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additional information
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the enzyme shows cytopathic effects and destroys cell monolayers
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additional information
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cysteine proteinases play a central role in tissue invasion and disruption of host defenses by digesting components of the extracellular matrix, immunoglobulins, complement, and cytokines
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additional information
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essential for pathogenicity of Entamoeba histolytica
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additional information
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essential for pathogenicity of Entamoeba histolytica
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additional information
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essential for pathogenicity of Entamoeba histolytica
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additional information
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essential for pathogenicity of Entamoeba histolytica
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additional information
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secreted cysteine proteases play an indispensable role in amoebic invasion and tissue destruction due to their hydrolytic and degradative activities towards extracellular matrix proteins
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additional information
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secreted cysteine proteases play an indispensable role in amoebic invasion and tissue destruction due to their hydrolytic and degradative activities towards extracellular matrix proteins
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additional information
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secreted cysteine proteases play an indispensable role in amoebic invasion and tissue destruction due to their hydrolytic and degradative activities towards extracellular matrix proteins
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additional information
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the cysteine proteinase EhCP112 and the adhesin EhADH112 assemble to form the EhCPADH complex involved in Entamoeba histolytica virulence
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additional information
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cysteine proteinases play a central role in tissue invasion and disruption of host defenses by digesting components of the extracellular matrix, immunoglobulins, complement, and cytokines
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