3.4.22.35: Histolysain

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For detailed information about Histolysain, go to the full flat file.

Reaction

hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec =

Synonyms

Amebapain, amoebapain, CP1, CP2, CP5, CP6, cysteine protease, cysteine protease 1, cysteine protease 2, cysteine protease 5, cysteine protease 6, cysteine proteinase 1, cysteine proteinase 5, EhCP1, EhCP112, EhCP2, EhCP5, Entamoeba histolytica 112kDa adhesin, Entamoeba histolytica cysteine protease, Entamoeba histolytica cysteine proteinase, Entamoeba histolytica cysteine proteinase 5, Entamoeba histolytica cysteine-proteinase, Entamoeba histolytica neutral thiol proteinase, Histolysin, More, PCP5, ppEhCP-B9, Proteinase, Entamoeba histolytica cysteine

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.35 Histolysain

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Results	in table
7	Activating Compound
8	AA Sequence
1	CAS Registry Number
12	Cloned(Commentary)
5	Expression
4	General Information
1	General Stability
44	Inhibitors
12	Ki Value [mM]
2	KM Value [mM]
17	Localization
15	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
78	Organism
13	pH Optimum
5	pH Range
1	pH Stability
3	pI Value
3	Posttranslational Modification
1	Protein Variants
16	Purification (Commentary)
3	Reaction
8	Reaction Type
41	Reference
6	Renatured (Commentary)
19	Source Tissue
8	Specific Activity [micromol/min/mg]
109	Substrates and Products (Substrate)
21	Subunits
67	Synonyms
6	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Expression

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Expression on EC 3.4.22.35 - Histolysain

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

CP5 expression is significantly higher in the Entamoeba histolytica strain EGG isolated from liver than in the other strains maintained in culture (5.6fold higher than strain 32, 4.1fold higher than strain HM1 and 3.0fold higher than cultured strain EGG)

Entamoeba histolytica

-

708440

cysteine protease 6 is upregulated in response to heat shock and during pathogen invasion of the host tissue

2 entries

when Entamoeba histolytica is grown in the presence of E-64, PCP5 levels are significantly increased

2 entries

cysteine protease 6 is upregulated in response to heat shock and during pathogen invasion of the host tissue

Entamoeba histolytica

C4LSI6

732864

cysteine protease 6 is upregulated in response to heat shock and during pathogen invasion of the host tissue

Entamoeba histolytica HM1:IMSS

-

-

when Entamoeba histolytica is grown in the presence of E-64, PCP5 levels are significantly increased

Entamoeba histolytica

-

717810

when Entamoeba histolytica is grown in the presence of E-64, PCP5 levels are significantly increased

Entamoeba histolytica HM1:IMSS

-

-