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Literature summary for 3.4.22.35 extracted from
- Entamoeba histolytica cysteine proteinases disrupt the polymeric structure of colonic mucin and alter its protective function (2003), Infect. Immun., 71, 838-844.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cystatin | - |
Entamoeba histolytica | |
| leupeptin | - |
Entamoeba histolytica |  |
| additional information | no inhibition by aprotinin, pepstatin, phosphoramidon, and pefabloc SC | Entamoeba histolytica | |
| tosylsulfonylleucylchloromethyl ketone | i.e. TLCK | Entamoeba histolytica | |
| tosylsulfonylphenylalanylchloromethyl ketone | i.e. TPCK | Entamoeba histolytica | |
| trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | - |
Entamoeba histolytica | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secretion | Entamoeba histolytica | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mucin MUC2 polymer + H2O | Entamoeba histolytica | enzyme is involved, together with other Entamoeba histolytica cysteine proteinases, in the degradation of mucin in the mucous layer of the colon epithelium, altering the protective function to facilitate parasite attachment | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-Arg-Arg-4-nitroanilide + H2O | - |
Entamoeba histolytica | benzyloxycarbonyl-Arg-Arg + 4-nitroaniline | - |
? | |
| mucin + H2O | - |
Entamoeba histolytica | ? | - |
? | |
| mucin MUC2 polymer + H2O | enzyme is involved, together with other Entamoeba histolytica cysteine proteinases, in the degradation of mucin in the mucous layer of the colon epithelium, altering the protective function to facilitate parasite attachment | Entamoeba histolytica | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Entamoeba histolytica cysteine proteinase | - |
Entamoeba histolytica |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Entamoeba histolytica |
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Release 2023.1 (January 2023)
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