3.4.22.35: Histolysain

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For detailed information about Histolysain, go to the full flat file.

Reaction

hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec =

Synonyms

Amebapain, amoebapain, CP1, CP2, CP5, CP6, cysteine protease, cysteine protease 1, cysteine protease 2, cysteine protease 5, cysteine protease 6, cysteine proteinase 1, cysteine proteinase 5, EhCP1, EhCP112, EhCP2, EhCP5, Entamoeba histolytica 112kDa adhesin, Entamoeba histolytica cysteine protease, Entamoeba histolytica cysteine proteinase, Entamoeba histolytica cysteine proteinase 5, Entamoeba histolytica cysteine-proteinase, Entamoeba histolytica neutral thiol proteinase, Histolysin, More, PCP5, ppEhCP-B9, Proteinase, Entamoeba histolytica cysteine

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.35 Histolysain

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Results	in table
7	Activating Compound
8	AA Sequence
1	CAS Registry Number
12	Cloned(Commentary)
5	Expression
4	General Information
1	General Stability
44	Inhibitors
12	Ki Value [mM]
2	KM Value [mM]
17	Localization
15	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
78	Organism
13	pH Optimum
5	pH Range
1	pH Stability
3	pI Value
3	Posttranslational Modification
1	Protein Variants
16	Purification (Commentary)
3	Reaction
8	Reaction Type
41	Reference
6	Renatured (Commentary)
19	Source Tissue
8	Specific Activity [micromol/min/mg]
109	Substrates and Products (Substrate)
21	Subunits
67	Synonyms
6	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Reaction

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Reaction on EC 3.4.22.35 - Histolysain

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec

3 entries

hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec

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hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec

from the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family)

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hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec

cleavage mechanism on mucin substrate, overview

Entamoeba histolytica

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