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Literature summary for 3.4.22.35 extracted from
- Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation (2006), Gastroenterology, 130, 721-730.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| functional expression of EhCP5 | Entamoeba histolytica |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of EhCP5-deficient amoeba by antisense inhibition showing no activity on mucin from cells LS174T and HT-29F Cl.16E or against CHO cell layers, enzyme-deficient amoeba cannot overcome the mucus barrier to disrupt CHO cell monolayers, overview | Entamoeba histolytica |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| E64 | specific inhibition | Entamoeba histolytica |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Entamoeba histolytica | the enzyme can degrade colon cell mucin and destroy epithelial cell layers | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | - |
gene ehcp5 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| trophozoite | - |
Entamoeba histolytica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme can degrade colon cell mucin and destroy epithelial cell layers | Entamoeba histolytica | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cysteine protease 5 | - |
Entamoeba histolytica |
| EhCP5 | - |
Entamoeba histolytica |
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Release 2023.1 (January 2023)
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