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Literature summary for 3.4.22.35 extracted from
- Specific and reversible inhibition of Entamoeba histolytica cysteine-proteinase activities by Zn2+: implications for adhesion and cell damage (1999), Arch. Med. Res., 30, 82-88.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | 77% inhibition of proteolytic activity at 2.5 mM, completely reversible by L-cystein, phenanthroline, and L-histidine, Zn2+ interferes with the fibronectin binding of the amoeba | Entamoeba histolytica |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein + H2O | Entamoeba histolytica | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| trophozoite | - |
Entamoeba histolytica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| azocasein + H2O | - |
Entamoeba histolytica | fragments of azocasein | - |
? | |
| Gelatin + H2O | - |
Entamoeba histolytica | ? | - |
? | |
| additional information | enzyme permits adhesion of trophozoites to cells via fibronectin binding, which can be inhibited by Zn2+ | Entamoeba histolytica | ? | - |
? | |
| protein + H2O | - |
Entamoeba histolytica | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Entamoeba histolytica cysteine-proteinase | - |
Entamoeba histolytica |
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