3.4.22.35: Histolysain

This is an abbreviated version!
For detailed information about Histolysain, go to the full flat file.

Reaction

hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg-/- in small molecule substrates including Z-Arg-Arg-/-NHMec =

Synonyms

Amebapain, amoebapain, CP1, CP2, CP5, CP6, cysteine protease, cysteine protease 1, cysteine protease 2, cysteine protease 5, cysteine protease 6, cysteine proteinase 1, cysteine proteinase 5, EhCP1, EhCP112, EhCP2, EhCP5, Entamoeba histolytica 112kDa adhesin, Entamoeba histolytica cysteine protease, Entamoeba histolytica cysteine proteinase, Entamoeba histolytica cysteine proteinase 5, Entamoeba histolytica cysteine-proteinase, Entamoeba histolytica neutral thiol proteinase, Histolysin, More, PCP5, ppEhCP-B9, Proteinase, Entamoeba histolytica cysteine

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.35 Histolysain

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Results	in table
7	Activating Compound
8	AA Sequence
1	CAS Registry Number
12	Cloned(Commentary)
5	Expression
4	General Information
1	General Stability
44	Inhibitors
12	Ki Value [mM]
2	KM Value [mM]
17	Localization
15	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
78	Organism
13	pH Optimum
5	pH Range
1	pH Stability
3	pI Value
3	Posttranslational Modification
1	Protein Variants
16	Purification (Commentary)
3	Reaction
8	Reaction Type
41	Reference
6	Renatured (Commentary)
19	Source Tissue
8	Specific Activity [micromol/min/mg]
109	Substrates and Products (Substrate)
21	Subunits
67	Synonyms
6	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Organism

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Organism on EC 3.4.22.35 - Histolysain

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Entamoeba dispar

gene edcp2 or acp2

668769

-

-

brenda

Entamoeba histolytica

17 entries

Entamoeba histolytica HM 1:IMSS

-

30321

-

-

brenda

Entamoeba histolytica HM1:IMSS

3 entries

Entamoeba histolytica

-

30316, 30318, 30319, 30321, 30322, 30323, 30324, 30325, 649500, 651493, 653742, 669261, 670707, 683417, 683468

-

-

brenda

Entamoeba histolytica

-

683468

Q01957, Q01958

UniProt

brenda

Entamoeba histolytica

-

701062, 708440, 717635, 717810, 731356, 732605

-

-

brenda

Entamoeba histolytica

-

732864

C4LSI6

UniProt

brenda

Entamoeba histolytica

and its derivative clone A

651056

-

-

brenda

Entamoeba histolytica

control strain and strains overexpressing EhRab7B and EhRab7B-GTP, activity secreted to the medium by the EhRab7B-GTP transformant is 4.3fold higher than the control transformant and has a 38% less total intracellular CP activity than the control transformant

683340

-

-

brenda

Entamoeba histolytica

enzyme is termed CP5

653256

Q95030

SwissProt

brenda

Entamoeba histolytica

gene ehcp112

668210

-

-

brenda

Entamoeba histolytica

gene Ehcp112, gene is encoded adjacent to Ehadh112

653261

-

-

brenda

Entamoeba histolytica

gene ehcp2

670467

-

-

brenda

Entamoeba histolytica

gene ehcp2 or acp2 encodes histolysain, gene ehcp1 or acp1 encodes amoebapain

668769

-

-

brenda

Entamoeba histolytica

gene ehcp5

668713

-

-

brenda

Entamoeba histolytica

isolate HM-1:IMSS, genes ehcp1, ehcp2, and ehcp5

670192

-

-

brenda

Entamoeba histolytica

low-virulence HMI strain and highly virulent 1659 clone, derived from HMI by hamster liver passages

30317

-

-

brenda

Entamoeba histolytica

overexpression of EhRab11B protein results in a 15fold increase in both, intracellular and secreted cysteine protease activity, suggesting that the three major cysteine proteases are trafficked via an EhRab11B-associated secretory pathway

683341

-

-

brenda

Entamoeba histolytica

overexpression of EhRab11B protein results in a 15fold increase in both, intracellular and secreted cysteine protease activity, suggesting that the three major cysteine proteases are trafficked via an EhRab11B-associated secretory pathway

683341

Q01957, Q01958

UniProt

brenda

Entamoeba histolytica

virulent strain HMI:IMSS

30320

-

-

brenda

Entamoeba histolytica HM1:IMSS

-

683417, 717635, 717810

-

-

brenda

Entamoeba histolytica HM1:IMSS

-

732864

C4LSI6

UniProt

brenda

Entamoeba histolytica HM1:IMSS

and its derivative clone A

651056

-

-

brenda