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Literature summary for 3.4.22.35 extracted from

  • Mitra, B.N.; Saito-Nakano, Y.; Nakada-Tsukui, K.; Sato, D.; Nozaki, T.
    Rab11B small GTPase regulates secretion of cysteine proteases in the enteric protozoan parasite Entamoeba histolytica (2007), Cell. Microbiol., 9, 2112-2125.
    View publication on PubMed
Search for more literature for 3.4.22.35

Inhibitors

Inhibitors Comment Organism Structure
E64 activity was completely abolished when trophozoites are pretreated with 200 mM of E64, a potent, irreversible and highly selective cysteine protease inhibitor; activity was completely abolished when trophozoites are pretreated with 200 mM of E64, a potent, irreversible and highly selective cysteine protease inhibitor; activity was completely abolished when trophozoites are pretreated with 200 mM of E64, a potent, irreversible and highly selective cysteine protease inhibitor Entamoeba histolytica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Entamoeba histolytica secreted cysteine proteases play an indispensable role in amoebic invasion and tissue destruction due to their hydrolytic and degradative activities towards extracellular matrix proteins ?
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 ?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
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 overexpression of EhRab11B protein results in a 15fold increase in both, intracellular and secreted cysteine protease activity, suggesting that the three major cysteine proteases are trafficked via an EhRab11B-associated secretory pathway
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Entamoeba histolytica Q01957 overexpression of EhRab11B protein results in a 15fold increase in both, intracellular and secreted cysteine protease activity, suggesting that the three major cysteine proteases are trafficked via an EhRab11B-associated secretory pathway
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Entamoeba histolytica Q01958 overexpression of EhRab11B protein results in a 15fold increase in both, intracellular and secreted cysteine protease activity, suggesting that the three major cysteine proteases are trafficked via an EhRab11B-associated secretory pathway
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information secreted cysteine proteases play an indispensable role in amoebic invasion and tissue destruction due to their hydrolytic and degradative activities towards extracellular matrix proteins Entamoeba histolytica ?
-
 ?
Z-Arg-Arg-7-amido-4-trifluoromethylcoumarin + H2O
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 Entamoeba histolytica Z-Arg-Arg + 7-amino-4-trifluoromethylcoumarin
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 ?

Synonyms

Synonyms Comment Organism
CP1
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 Entamoeba histolytica
CP2
-
 Entamoeba histolytica
CP5
-
 Entamoeba histolytica
cysteine protease 1 one of the three major cysteine proteases Entamoeba histolytica
cysteine protease 2 one of the three major cysteine proteases Entamoeba histolytica
cysteine protease 5 one of the three major cysteine proteases Entamoeba histolytica