3.4.21.35: tissue kallikrein
This is an abbreviated version!
For detailed information about tissue kallikrein, go to the full flat file.
Word Map on EC 3.4.21.35
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3.4.21.35
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kallikreins
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prostatectomy
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gleason
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androgen
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rectal
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hyperplasia
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transrectal
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ultrasound
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preoperative
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adenocarcinoma
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prostate-specific
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seminal
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lymph
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followup
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metastases
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radiotherapy
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postoperative
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needle
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urological
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staging
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pelvic
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bradykinin
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lncap
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transurethral
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beam
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retropubic
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kallikrein-kinin
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kininogens
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ultrasonography
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sextant
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suspicious
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brachytherapy
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nadir
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extraprostatic
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urologist
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aprotinin
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immunosensors
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actuarial
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ultrasound-guided
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multiparametric
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incontinence
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lymphadenectomy
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transperineal
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antiandrogens
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hk2
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organ-confined
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extracapsular
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biotechnology
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medicine
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drug development
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finasteride
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kininase
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mcrpc
- 3.4.21.35
- kallikreins
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prostatectomy
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gleason
- androgen
- rectal
- hyperplasia
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transrectal
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ultrasound
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preoperative
- adenocarcinoma
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prostate-specific
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seminal
- lymph
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followup
- metastases
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radiotherapy
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postoperative
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needle
- urological
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staging
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pelvic
- bradykinin
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lncap
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transurethral
-
beam
-
retropubic
-
kallikrein-kinin
- kininogens
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ultrasonography
-
sextant
-
suspicious
-
brachytherapy
-
nadir
-
extraprostatic
-
urologist
- aprotinin
-
immunosensors
-
actuarial
-
ultrasound-guided
-
multiparametric
- incontinence
-
lymphadenectomy
-
transperineal
-
antiandrogens
- hk2
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organ-confined
-
extracapsular
- biotechnology
- medicine
- drug development
- finasteride
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kininase
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mcrpc
Reaction
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds =
Synonyms
bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK15, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 15, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme
ECTree
3.4.21.35 tissue kallikreinAdvanced search results
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Natural Substrates Products on EC 3.4.21.35 - tissue kallikrein
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
epithelial sodium channel + H2O
activated epithelial sodium channel + ?
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?
kininogen + H2O
bradykinin + kinin heavy chain + kinin light chain
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important role in bradykinin release in seminal fluid
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?
low-molecular-weight kininogen + H2O
GMISLM + KRPPGFSPFR + SSRIG
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KRPPGFSPFR is kallidin
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?
prolactin + H2O
lactin + ?
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three cleavage sites between Arg174-Arg175, Lys185-Phe186 and Arg188-Cys189
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?
single-chain tissue-type plasminogen activator + H2O
?
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glandular kallikrein 24 may play a role in degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis, due not only to its own activity, but also to that of plasmin produced by the single-chain tissue-type plasminogen activator-converting activity of glandular kallikrein 24
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?
insulin-like growth factor binding proteins
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enhancement of IGF bioavailability, role in tumor progression
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?
kininogen + H2O
kallidin + kinin heavy chain + kinin light chain
best substrate
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?
kininogen + H2O
kallidin + kinin heavy chain + kinin light chain
enzyme is involved in inflammation, sepsis, pancreatitis, bone metabolism, heart disease, renal disease, and cancer through release of kallidin, i.e. Lys-bradykinin
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?
polypeptide + H2O
peptides
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S1' and S2' subsites of the enzyme play a determinant role in the recognition and hydrolysis of substrates
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?
polypeptide + H2O
peptides
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serine at position P1' and arginine at position P2' results in high activity
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?
polypeptide + H2O
peptides
implicated in processing of growth factrors and peptide hormones
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?
additional information
?
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the enzyme is implicated in the pathology of various inflammatory disorders, the enzyme is an attractive target for therapeutic intervention in diseases such as asthma, pancreatitis and rheumatoid arthritis
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?
additional information
?
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likely the physiological activator of the zymogen form of prostate-specific antigen in the prostate
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?
additional information
?
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involved in blood pressure regulation and inflammation processes
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?
additional information
?
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decrease in activity of tissue kallikrein results from a genetic mutation in humans and is associated with a newly discovered form of arterial dysfunction characterized by an inward remodeling of the brachial artery, which is not adapted to a chronic increase in wall shear stress
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?
additional information
?
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tissue kallikrein 4 regulates the structure and functions of the tumor-associated urokinase-type plasminogen activator receptor
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?
additional information
?
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tissue kallikrein plays an important role in the airways by processing the pro-form of the epidermal growth factor to mature epidermal growth factor in airway submucosal gland cells. The activity of tissue kallikrein is regulated by hyaluronan. Tissue kallikrein is inhibited in the presence of native hyaluronan in the airway and in the submucosal gland duct. Hyaluronan depolymerization is expected to cause activation of tissue kallikrein, release of epidermal growth factor and signaling of epidermal growth factor receptor and to lead to hypertrophy of tracheal submucosal gland cells and hyperplasia as well as mucus hypersecretion with subsequent airflow obstruction
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?
additional information
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tissue kallikreins may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion, and thus, may represent attractive drug targets to consider for therapeutic intervention
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?
additional information
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tissue kallikrein stimulates capillary tube formation and promotes cell migration of cultured endothelial cells, expression of human tissue kallikrein in rat heart reduces infarct size after myocardial infarction, tissue kallikrein inhibits GSK-3beta activity and stimulates vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in cultured endothelial cells
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?
additional information
?
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kallikrein 24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis
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?
