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3.4.21.35: tissue kallikrein

This is an abbreviated version!
For detailed information about tissue kallikrein, go to the full flat file.

Word Map on EC 3.4.21.35

Reaction

Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds =

Synonyms

bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK15, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 15, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.35 tissue kallikrein

KM Value

KM Value on EC 3.4.21.35 - tissue kallikrein

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.005
2-aminobenzoyl-TSVIRRVQ-ethylenediamine
-
-
-
0.0043
Abz-ALFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0032
Abz-FLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0015
Abz-FRSSR-Q-EDDnp
pH and temperature not specified in the publication
0.00036
Abz-GFSPFRSLRI-Q-EDDnp
pH and temperature not specified in the publication
0.0002
Abz-GFSPFRSSRI-Q-EDDnp
pH and temperature not specified in the publication
0.0062
Abz-GLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0034
Abz-HLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-ILFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0035
Abz-KAFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.003
Abz-KFFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0016
Abz-KLFFSK-EDDnp
-
at pH 7.5 and 37°C
0.0006
Abz-KLFRSK-EDDnp
-
at pH 7.5 and 37°C
0.0062
Abz-KLFSAKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFSGKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFSIKQ-EDDnp
-
at pH 7.5 and 37°C
0.0037
Abz-KLFSLKQ-EDDnp
-
at pH 7.5 and 37°C
0.0023
Abz-KLFSNKQ-EDDnp
-
at pH 7.5 and 37°C
0.0015
Abz-KLFSRKQ-EDDnp
-
at pH 7.5 and 37°C
0.0032
Abz-KLFSSDQ-EDDnp
-
at pH 7.5 and 37°C
0.0127
Abz-KLFSSEQ-EDDnp
-
at pH 7.5 and 37°C
0.0016
Abz-KLFSSGQ-EDDnp
-
at pH 7.5 and 37°C
0.0033
Abz-KLFSSIQ-EDDnp
-
at pH 7.5 and 37°C
0.0018
Abz-KLFSSK-EDDnp
-
at pH 7.5 and 37°C
0.0018
Abz-KLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0032
Abz-KLFSSLQ-EDDnp
-
at pH 7.5 and 37°C
0.0045
Abz-KLFSSNQ-EDDnp
-
at pH 7.5 and 37°C
0.0043
Abz-KLFSSQQ-EDDnp
-
at pH 7.5 and 37°C
0.0016
Abz-KLFSSRQ-EDDnp
-
at pH 7.5 and 37°C
0.0059
Abz-KLFSSSQ-EDDnp
-
at pH 7.5 and 37°C
0.0104
Abz-KLFSSVQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFSVKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KLFTSK-EDDnp
-
at pH 7.5 and 37°C
0.0024
Abz-KLFWSK-EDDnp
-
at pH 7.5 and 37°C
0.00062 - 0.00065
Abz-KLRSSQ-EDDnp
0.0034
Abz-KLYSSK-EDDnp
-
at pH 7.5 and 37°C
0.0025
Abz-KPFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0019
Abz-KVFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0027
Abz-KYFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0046
Abz-LLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.009
Abz-MISLMKLP-Q-EDDnp
pH and temperature not specified in the publication
0.0007
Abz-MISLMKRP-Q-EDDnp
pH and temperature not specified in the publication
0.0017
Abz-NLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0052
Abz-QLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0041
Abz-RLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0021
Abz-VLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.08
acetyl-2-aminohexanoic acid-Arg methyl ester
-
-
0.6 - 1.14
acetyl-Ala-Arg methyl ester
8.6
acetyl-Ala-Arg-Ala
-
pH 8.0, 25°C
-
0.222
acetyl-Ala-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.035
acetyl-Ala-Phe-Arg methyl ester
-
pH 8.0, 25°C
0.17
acetyl-Ala-Phe-Arg-Ala
-
pH 8.0, 25°C
0.11
acetyl-Ala-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.571
acetyl-Ala-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
4.1
acetyl-Arg methyl ester
-
pH 8.0, 25°C
16
acetyl-Arg p-nitroanilide
-
pH 8.0, 25°C
14
acetyl-Arg-Ala-NH2
-
pH 8.0, 25°C
2.5
acetyl-D-Ala-Arg methyl ester
-
pH 9.0, 25°C
0.95
acetyl-D-Phe-Arg methyl ester
-
pH 9.0, 25°C
0.849
acetyl-Glu-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.291
acetyl-Glu-Lys-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.765
acetyl-Glu-Phe-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.929
acetyl-Glu-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.77
acetyl-Gly-Arg methyl ester
-
pH 9.0, 25°C
26
acetyl-Gly-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.199
acetyl-Ile-Arg methyl ester
-
pH 9.0, 25°C
0.0249
acetyl-Leu-Arg methyl ester
-
pH 9.0, 25°C
0.182
acetyl-Met-Arg methyl ester
-
pH 9.0, 25°C
0.14
acetyl-Phe-Arg ethyl ester
-
-
0.0244 - 0.0311
acetyl-Phe-Arg methyl ester
0.27
acetyl-Phe-Arg-Ala
-
pH 8.0, 25°C
-
0.15
acetyl-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.21
acetyl-Phe-Arg-Ser-NH2
-
pH 9.0, 25°C
0.31
acetyl-Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.04
acetyl-Phe-Arg-Ser-Val-NH2
-
pH 9.0, 25°C
0.153
acetyl-Pro-Arg methyl ester
-
pH 9.0, 25°C
0.089
acetyl-Pro-Phe-Arg methyl ester
-
pH 8.0, 25°C
0.21
acetyl-Pro-Phe-Arg-Ala
-
pH 8.0, 25°C
0.087
acetyl-Pro-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.027
acetyl-Trp-Arg methyl ester
-
pH 9.0, 25°C
0.132
acetyl-Tyr-Arg methyl ester
-
pH 9.0, 25°C
0.283
acetyl-Val-Arg methyl ester
-
pH 9.0, 25°C
0.02
Ala-Arg-Arg-4-methylcoumarin 7-amide
-
-
0.02
Ala-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.45
benzoyl-Pro-Phe-Arg-p-nitroanilide
-
pH 8.0, 37°C
0.243
benzyloxycarbonyl-Arg methyl ester
-
pH 8.0, 25°C
1.25
benzyloxycarbonyl-Arg-Ala-NH2
-
pH 8.0, 25°C
0.327
benzyloxycarbonyl-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.209
benzyloxycarbonyl-Pro-Gly-Arg methyl ester
-
-
0.0114
benzyloxycarbonyl-Pro-Phe-Arg methyl ester
-
pH 9.0, 25°C
61.1
citrated bovine plasma
-
pH 7.8, 37°C
-
50.8
citrated dog plasma
-
pH 7.8, 37°C
-
0.00018 - 0.0031
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
0.001 - 0.07
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
0.0183 - 28.4
D-Val-Leu-Arg-p-nitroanilide
0.868
D-Val-Leu-Lys-4-nitroanilide
-
pH 8.5, 37°C
0.528
D-Val-Leu-Lys-p-nitroanilide
-
pH 8.0, 37°C
0.12 - 58.8
DL-Val-Leu-Arg-p-nitroanilide
0.064
FSPFRSVQ
-
pH 9.0, 25°C
0.27
Gln-Ala-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
1.18
Gly-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
17.6
human high molecular weight kininogen
-
pH 7.8, 37°C
-
12.7
human low molecular weight kininogen
-
pH 7.8, 37°C
-
0.071
Leu-Leu-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.383
N-alpha-acetyl-Arg-p-nitroanilide
-
pH 8.5, 37°C
50
N-alpha-acetyl-Tyr ethyl ester
-
pH 8.0, 40°C
0.104
N-alpha-benzoyl-L-Arg ethyl ester
-
pH 8.0, 40°C
0.125
N-alpha-benzoyl-L-Arg methyl ester
-
pH 8.0, 40°C
0.08 - 0.333
N-alpha-benzoyl-L-arginine ethyl ester
12.3
N-alpha-benzoyl-L-citrulline methyl ester
-
pH 8.0, 40°C
2
N-alpha-benzoyl-L-Lys methyl ester
-
pH 8.0, 40°C
2.44
N-alpha-benzoyl-L-Orn methyl ester
-
pH 8.0, 40°C
0.031
N-alpha-toluenesulfonyl-L-Arg methyl ester
-
pH 8.0, 40°C
0.022 - 0.117
N-alpha-tosyl-L-arginine methyl ester
0.00027
o-aminobenzoyl-AIKFFIRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00013
o-aminobenzoyl-AIKFFQRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0018
o-aminobenzoyl-AIKFFSAE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00021
o-aminobenzoyl-AIKFFSKE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0013
o-aminobenzoyl-AIKFFSPE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00036
o-aminobenzoyl-AIKFFSRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00094
o-aminobenzoyl-AIKFFSSE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00023
o-aminobenzoyl-AIKFFTRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0002 - 0.0006
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
0.0009 - 0.0073
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
0.0007
o-aminobenzoyl-GFSPF-4-(aminocyclohexyl)alanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0038
o-aminobenzoyl-GFSPF-4-(aminomethyl)-N-isopropylphenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0003
o-aminobenzoyl-GFSPF-4-(aminomethyl)phenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00064
o-aminobenzoyl-GFSPF-4-piperidinylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.001
o-aminobenzoyl-GFSPF-Nim-(dimethyl)histidine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00096 - 0.00147
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
0.0067 - 0.0104
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
0.0004 - 0.00076
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
0.00035 - 0.0014
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
0.00041 - 0.00051
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
0.00017 - 0.00251
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
0.0023 - 0.0047
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.0027
o-aminobenzoyl-LPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.0007
o-aminobenzoyl-LPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.003 - 0.00735
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
0.00223 - 0.0024
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
0.0036
o-aminobenzoyl-Phe-4-(aminomethyl)phenylalanine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0002 - 0.00033
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
0.00024 - 0.00077
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
0.0007
o-aminobenzoyl-Phe-Nim-(dimethyl)histidine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0039 - 0.0042
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.0003 - 0.0455
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.00023
o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.0005
o-aminobenzoyl-VMIAALPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.057
PFRSVQ
-
pH 9.0, 25°C
2.2
Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.44
Phe-Ser-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.07 - 0.114
Pro-Phe-Arg-4-methylcoumarin 7-amide
0.53
Pro-Phe-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.04
Pro-Phe-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.066
RPPGFSPFRSVQ
-
pH 9.0, 25°C
0.516 - 0.842
succinyl-Val-Pro-Phe-thiobenzyl ester
0.103
tosyl-Gly-Pro-Arg-p-nitroanilide
-
pH 8.0, 37°C
0.28
Val-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.048
Val-Pro-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.067
Z-L-Phe-L-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 25°C
additional information
additional information
-