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3.4.21.35: tissue kallikrein

This is an abbreviated version!
For detailed information about tissue kallikrein, go to the full flat file.

Word Map on EC 3.4.21.35

Reaction

Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds =

Synonyms

bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK15, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 15, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.35 tissue kallikrein

KI Value

KI Value on EC 3.4.21.35 - tissue kallikrein

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003
Abz-KDFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0035
Abz-KEFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0026
Abz-KGFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0012
Abz-KHFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0005
Abz-KIFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0012
Abz-KKFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.002
Abz-KLASSK-EDDnp
-
at pH 7.5 and 37°C
0.0032
Abz-KLDSSK-EDDnp
-
at pH 7.5 and 37°C
0.003
Abz-KLESSK-EDDnp
-
at pH 7.5 and 37°C
0.0047
Abz-KLFESK-EDDnp
-
at pH 7.5 and 37°C
0.018
Abz-KLFHSK-EDDnp
-
at pH 7.5 and 37°C
0.0014
Abz-KLFISK-EDDnp
-
at pH 7.5 and 37°C
0.0006
Abz-KLFKSK-EDDnp
-
at pH 7.5 and 37°C
0.0014
Abz-KLFLSK-EDDnp
-
at pH 7.5 and 37°C
0.0083
Abz-KLFNSK-EDDnp
-
at pH 7.5 and 37°C
0.0014
Abz-KLFPSK-EDDnp
-
at pH 7.5 and 37°C
0.0061
Abz-KLFSEKQ-EDDnp
-
at pH 7.5 and 37°C
0.0096
Abz-KLFSFKQ-EDDnp
-
at pH 7.5 and 37°C
0.0014
Abz-KLFSHKQ-EDDnp
-
at pH 7.5 and 37°C
0.0048
Abz-KLFSPKQ-EDDnp
-
at pH 7.5 and 37°C
0.0009
Abz-KLFSQKQ-EDDnp
-
at pH 7.5 and 37°C
0.0017
Abz-KLFVSK-EDDnp
-
at pH 7.5 and 37°C
0.0022
Abz-KLGSSK-EDDnp
-
at pH 7.5 and 37°C
0.0013
Abz-KLHSSK-EDDnp
-
at pH 7.5 and 37°C
0.0002
Abz-KLISSK-EDDnp
-
at pH 7.5 and 37°C
0.0003
Abz-KLKSSK-EDDnp
-
at pH 7.5 and 37°C
0.0015
Abz-KLLSSK-EDDnp
-
at pH 7.5 and 37°C
0.001
Abz-KLMSSK-EDDnp
-
at pH 7.5 and 37°C
0.0011
Abz-KLNSSK-EDDnp
-
at pH 7.5 and 37°C
0.0022
Abz-KLPSSK-EDDnp
-
at pH 7.5 and 37°C
0.0022
Abz-KLQSSK-EDDnp
-
at pH 7.5 and 37°C
0.0016
Abz-KLRSSK-EDDnp
-
at pH 7.5 and 37°C
0.0018
Abz-KLSSSK-EDDnp
-
at pH 7.5 and 37°C
0.0023
Abz-KLTSSK-EDDnp
-
at pH 7.5 and 37°C
0.0017
Abz-KLVSSK-EDDnp
-
at pH 7.5 and 37°C
0.001
Abz-KLWSSK-EDDnp
-
at pH 7.5 and 37°C
0.0009
Abz-KMFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0041
Abz-KNFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0006
Abz-KQFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0011
Abz-KRFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0052
Abz-KSFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0007
Abz-KTFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.0009
Abz-KWFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.000424
acetyl-D-Lys-L-Phe-L-Arg-D-Arg-L-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.000494
acetyl-D-Lys-L-Phe-L-Arg-D-Arg-L-Gln-NH2
-
pH 9.0, 37°C
0.0044
acetyl-D-Lys-L-Phe-L-Arg-D-Arg-NH2
-
pH 9.0, 37°C
0.000029
acetyl-D-Lys-L-Phe-L-Arg-L-Leu-L-Glu-NH2
-
pH 9.0, 37°C
0.000002
Bauhinia bauhinioides trypsin inhibitor II
-
pH 8.0, 37°C
-
33
diglutamic acid
-
at pH 7.5 and 37°C
0.00000007
diisopropyl fluorophosphate
-
pH 7.2, 25°C
0.00000013
DX-2300
-
in 20 mM Tris/HCl buffer, pH 7.5, 150 mM NaCl, 1 mM EDTA, 0.1% poly(ethylene glycol)-8000 and 0.1% Triton X-100
-
0.0016 - 0.0036
fukugetin
0.0000068
kallistatin
-
at pH 7.5 and 37°C
-
0.00033
o-aminobenzoyl-AIKFFARE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0004
o-aminobenzoyl-AIKFFERE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00015
o-aminobenzoyl-AIKFFKRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00032
o-aminobenzoyl-AIKFFLRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00035
o-aminobenzoyl-AIKFFNRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00009
o-aminobenzoyl-AIKFFPRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00021
o-aminobenzoyl-AIKFFRRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00051
o-aminobenzoyl-AIKFFSEE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.001
o-aminobenzoyl-AIKFFSIE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00019
o-aminobenzoyl-AIKFFSLE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00073
o-aminobenzoyl-AIKFFSNE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0006
o-aminobenzoyl-AIKFFSQE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00032
o-aminobenzoyl-AIKFFSTE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0017
o-aminobenzoyl-AIKFFSVE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00022
o-aminobenzoyl-AIKFFVRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.000022
o-aminobenzoyl-D-Lys-L-Phe-L-Arg-D-Arg-L-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.000029
o-aminobenzoyl-D-Lys-L-Phe-L-Phe-D-Arg-L-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.00005
o-aminobenzoyl-F-4-(aminomethyl)cyclohexylalanine-SRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.0042
o-aminobenzoyl-TSVIRRPQ-ethylenediamine
-
pH 9.0, 37°C
0.000000025
Protein C inhibitor
-
pH 7.5, 37°C
-
0.0033
Zn2+-dependent small-molecule competitive inhibitor
-
-
-
additional information
additional information
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