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3.4.21.35: tissue kallikrein

This is an abbreviated version!
For detailed information about tissue kallikrein, go to the full flat file.

Word Map on EC 3.4.21.35

Reaction

Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds =

Synonyms

bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK15, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 15, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.35 tissue kallikrein

Turnover Number

Turnover Number on EC 3.4.21.35 - tissue kallikrein

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
Abz-ALFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.09
Abz-FLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
1.6
Abz-FRSSR-Q-EDDnp
pH and temperature not specified in the publication
4.6
Abz-GFSPFRSLRI-Q-EDDnp
pH and temperature not specified in the publication
17.7
Abz-GFSPFRSSRI-Q-EDDnp
pH and temperature not specified in the publication
0.03
Abz-GLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.1
Abz-HLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.06
Abz-ILFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KAFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KFFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFFSK-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFRSK-EDDnp
-
at pH 7.5 and 37°C
0.43
Abz-KLFSAKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFSGKQ-EDDnp
-
at pH 7.5 and 37°C
0.09
Abz-KLFSIKQ-EDDnp
-
at pH 7.5 and 37°C
0.15
Abz-KLFSLKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFSNKQ-EDDnp
-
at pH 7.5 and 37°C
0.15
Abz-KLFSRKQ-EDDnp
-
at pH 7.5 and 37°C
0.05
Abz-KLFSSDQ-EDDnp
-
at pH 7.5 and 37°C
0.5
Abz-KLFSSEQ-EDDnp
-
at pH 7.5 and 37°C
0.09
Abz-KLFSSGQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KLFSSIQ-EDDnp
-
at pH 7.5 and 37°C
0.1
Abz-KLFSSK-EDDnp
-
at pH 7.5 and 37°C
0.1
Abz-KLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.08
Abz-KLFSSLQ-EDDnp
-
at pH 7.5 and 37°C
0.07
Abz-KLFSSNQ-EDDnp
-
at pH 7.5 and 37°C
0.14
Abz-KLFSSQQ-EDDnp
-
at pH 7.5 and 37°C
0.17
Abz-KLFSSRQ-EDDnp
-
at pH 7.5 and 37°C
0.43
Abz-KLFSSSQ-EDDnp
-
at pH 7.5 and 37°C
0.06
Abz-KLFSSVQ-EDDnp
-
at pH 7.5 and 37°C
0.35
Abz-KLFSVKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFTSK-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KLFWSK-EDDnp
-
at pH 7.5 and 37°C
0.85
Abz-KLYSSK-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KPFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.04
Abz-KVFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-KYFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.07
Abz-LLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.02
Abz-MISLMKLP-Q-EDDnp
pH and temperature not specified in the publication
0.33
Abz-MISLMKRP-Q-EDDnp
pH and temperature not specified in the publication
0.28
Abz-NLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.15
Abz-QLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.13
Abz-RLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
0.13
Abz-VLFSSKQ-EDDnp
-
at pH 7.5 and 37°C
1180
acetyl-2-aminohexanoic acid-Arg methyl ester
-
pH 9.0, 25°C
682
acetyl-Ala-Arg methyl ester
-
pH 9.0, 25°C
0.0542
acetyl-Ala-Arg-Ala
-
pH 8.0, 25°C
-
6.74
acetyl-Ala-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.87
acetyl-Ala-Phe-Arg-Ala
-
pH 8.0, 25°C
1.71
acetyl-Ala-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
0.72
acetyl-Ala-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.02
acetyl-Arg-Ala-NH2
-
pH 8.0, 25°C
0.05
acetyl-Arg-p-nitroanilide
-
pH 8.0, 25°C
4.6
acetyl-D-Ala-Arg methyl ester
-
pH 9.0, 25°C
49
acetyl-D-Phe-Arg methyl ester
-
pH 9.0, 25°C
9.2
acetyl-Glu-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.029
acetyl-Glu-Lys-Arg-p-nitroanilide
-
pH 8.5, 37°C
6.62
acetyl-Glu-Phe-Arg-p-nitroanilide
-
pH 8.5, 37°C
0.38
acetyl-Glu-Thr-Arg-p-nitroanilide
-
pH 8.5, 37°C
385
acetyl-Gly-Arg methyl ester
-
pH 9.0, 25°C
0.77
acetyl-Gly-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
727
acetyl-Ile-Arg methyl ester
-
pH 9.0, 25°C
634
acetyl-Leu-Arg methyl ester
-
pH 9.0, 25°C
1380
acetyl-Met-Arg methyl ester
-
pH 9.0, 25°C
915
acetyl-Phe-Arg methyl ester
-
pH 9.0, 25°C
0.81
acetyl-Phe-Arg-Ala
-
pH 8.0, 25°C
-
1.69
acetyl-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
2.1
acetyl-Phe-Arg-Ser-NH2
-
pH 9.0, 25°C
6.8
acetyl-Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
11.6
acetyl-Phe-Arg-Ser-Val-NH2
-
pH 9.0, 25°C
806
acetyl-Pro-Arg methyl ester
-
pH 9.0, 25°C
0.24
acetyl-Pro-Phe-Arg-Ala
-
pH 8.0, 25°C
0.78
acetyl-Pro-Phe-Arg-p-nitroanilide
-
pH 8.0, 25°C
438
acetyl-Trp-Arg methyl ester
-
pH 9.0, 25°C
680
acetyl-Tyr-Arg methyl ester
-
pH 9.0, 25°C
964
acetyl-Val-Arg methyl ester
-
pH 9.0, 25°C
0.12
Ala-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.113
benzyloxycarbonyl-Arg-Ala-NH2
-
pH 8.0, 25°C
0.014
benzyloxycarbonyl-Arg-p-nitroanilide
-
pH 8.0, 25°C
259
benzyloxycarbonyl-Pro-Gly-Arg methyl ester
-
pH 9.0, 25°C
537
benzyloxycarbonyl-Pro-Phe-Arg methyl ester
-
pH 9.0, 25°C
3.18 - 95.3
D-Pro-Phe-Arg-4-methylcoumarin-7-amide
0.05 - 12.5
D-Pro-Phe-Phe-4-methylcoumarin-7-amide
6.6
D-Val-Leu-Arg-p-nitroanilide
-
pH 8.5, 37°C
4.1
D-Val-Leu-Lys-4-nitroanilide
-
pH 8.5, 37°C
0.8 - 1.16
DL-Val-Leu-Arg-p-nitroanilide
6.4
FSPFRSVQ
-
pH 9.0, 25°C
0.0038
Gln-Ala-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.0035
Gly-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.04
Leu-Leu-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.154
N-alpha-acetyl-Arg-p-nitroanilide
-
pH 8.5, 37°C
11.2
N-alpha-acetyl-Tyr ethyl ester
-
pH 8.0, 25°C
123
N-alpha-benzoyl-L-Arg ethyl ester
-
pH 8.0, 25°C
154
N-alpha-benzoyl-L-Arg methyl ester
-
pH 8.0, 25°C
53.8 - 100
N-alpha-benzoyl-L-arginine ethyl ester
86.4
N-alpha-benzoyl-L-citrulline methyl ester
-
pH 8.0, 25°C
15.5
N-alpha-benzoyl-L-Lys methyl ester
-
pH 8.0, 25°C
1.8
N-alpha-benzoyl-L-Orn methyl ester
-
pH 8.0, 25°C
2.7
N-alpha-toluenesulfonyl-L-Arg methyl ester
-
pH 8.0, 25°C
2.35 - 9.38
N-alpha-tosyl-L-arginine methyl ester
0.05
o-aminobenzoyl-AIKFFIRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.02
o-aminobenzoyl-AIKFFQRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.54
o-aminobenzoyl-AIKFFSAE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.21
o-aminobenzoyl-AIKFFSKE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.05
o-aminobenzoyl-AIKFFSPE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
3.33
o-aminobenzoyl-AIKFFSRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.3
o-aminobenzoyl-AIKFFSSE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.04
o-aminobenzoyl-AIKFFTRE-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
1.4 - 7
o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine
0.9 - 1.6
o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
0.51
o-aminobenzoyl-GFSPF-4-(aminocyclohexyl)alanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.81
o-aminobenzoyl-GFSPF-4-(aminomethyl)-N-isopropylphenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
1.8
o-aminobenzoyl-GFSPF-4-(aminomethyl)phenylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.61
o-aminobenzoyl-GFSPF-4-piperidinylalanine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
2.1
o-aminobenzoyl-GFSPF-Nim-(dimethyl)histidine-SSRPQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
6.6 - 12
o-aminobenzoyl-GFSPFRAPRVQ-ethylenediamine 2,4-dinitrophenol
3 - 3.1
o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
1 - 7.5
o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine
0.94 - 4
o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine
1.5 - 40.1
o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
3.1 - 14.7
o-aminobenzoyl-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
0.04 - 0.076
o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.032
o-aminobenzoyl-LPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.014
o-aminobenzoyl-LPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.73 - 1.49
o-aminobenzoyl-MTEMARRPQ-ethylenediamine 2,4-dinitrophenol
3.27 - 5.86
o-aminobenzoyl-MTSVIRRPQ-ethylenediamine 2,4-dinitrophenol
1
o-aminobenzoyl-Phe-4-(aminomethyl)phenylalanine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
12.7 - 18.7
o-aminobenzoyl-Phe-Arg-Arg-ethylenediamine 2,4-dinitrophenol
18.4 - 21.8
o-aminobenzoyl-Phe-Arg-Lys-GFSPFRSVTVQ-ethylenediamine 2,4-dinitrophenol
1.2
o-aminobenzoyl-Phe-Nim-(dimethyl)histidine-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 9.0, 37°C
0.4 - 7.1
o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.6 - 1.1
o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine
0.0005
o-aminobenzoyl-VMIAALPRTMFIQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
0.004
o-aminobenzoyl-VMIAALPRTMQ-N-(2,4-dinitrophenyl)ethylene diamine
-
pH 8.0, 37°C
5.7
PFRSVQ
-
pH 9.0, 25°C
2.8
Phe-Arg-Ser-Val-Gln
-
pH 9.0, 25°C
0.0065
Phe-Ser-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
5.3 - 12.5
Pro-Phe-Arg-4-methylcoumarin 7-amide
0.031
Pro-Phe-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.917
Pro-Phe-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
5.7
RPPGFSPFRSVQ
-
pH 9.0, 25°C
2 - 29
succinyl-Val-Pro-Phe-thiobenzyl ester
0.0075
Val-Pro-Arg-7-amido-4-methylcoumarin
37°C, pH 7.5
0.0267
Val-Pro-Arg-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
additional information
additional information
-