3.4.21.35: tissue kallikrein

This is an abbreviated version!
For detailed information about tissue kallikrein, go to the full flat file.

Word Map on EC 3.4.21.35

3.4.21.35

kallikreins

prostatectomy

gleason

androgen

rectal

hyperplasia

transrectal

ultrasound

preoperative

adenocarcinoma

prostate-specific

seminal

lymph

followup

metastases

radiotherapy

postoperative

needle

urological

staging

pelvic

bradykinin

lncap

transurethral

beam

retropubic

kallikrein-kinin

kininogens

ultrasonography

sextant

suspicious

brachytherapy

nadir

extraprostatic

urologist

aprotinin

immunosensors

actuarial

ultrasound-guided

multiparametric

incontinence

lymphadenectomy

transperineal

antiandrogens

hk2

organ-confined

extracapsular

biotechnology

medicine

drug development

finasteride

kininase

mcrpc

Reaction

Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds =

Synonyms

bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK15, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 15, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.35 tissue kallikrein

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Results	in table
21	Activating Compound
47	AA Sequence
28	Application
2	CAS Registry Number
25	Cloned(Commentary)
1	Crystallization (Commentary)
18153	Disease/ Diagnostics
15	Expression
37	General Information
1	General Stability
15	IC50 Value
216	Inhibitors
44	kcat/KM [mM/s]
76	Ki Value [mM]
207	KM Value [mM]
23	Localization
9	Metals/Ions
40	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
168	Organism
20	PDB ID
28	pH Optimum
4	pH Range
1	pH Stability
17	Posttranslational Modification
2	Protein Variants
47	Purification (Commentary)
6	Reaction
1	Reaction Type
163	Reference
257	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
486	Substrates and Products (Substrate)
28	Subunits
183	Synonyms
19	Temperature Optimum [°C]
3	Temperature Stability [°C]
183	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.21.35 - tissue kallikrein

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P09582 pBLAST

ESTA_CANLF

Canis lupus familiaris

260

28746

Swiss-Prot