3.4.21.35: tissue kallikrein

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For detailed information about tissue kallikrein, go to the full flat file.

Reaction

Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds =

Synonyms

bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK15, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 15, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.35 tissue kallikrein

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Results	in table
21	Activating Compound
47	AA Sequence
28	Application
2	CAS Registry Number
25	Cloned(Commentary)
1	Crystallization (Commentary)
18153	Disease/ Diagnostics
15	Expression
37	General Information
1	General Stability
15	IC50 Value
216	Inhibitors
44	kcat/KM [mM/s]
76	Ki Value [mM]
207	KM Value [mM]
23	Localization
9	Metals/Ions
40	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
168	Organism
20	PDB ID
28	pH Optimum
4	pH Range
1	pH Stability
17	Posttranslational Modification
2	Protein Variants
47	Purification (Commentary)
6	Reaction
1	Reaction Type
163	Reference
257	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
486	Substrates and Products (Substrate)
28	Subunits
183	Synonyms
19	Temperature Optimum [°C]
3	Temperature Stability [°C]
183	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.21.35 - tissue kallikrein

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

R53H

Homo sapiens

-

inactive

696535

Y228A

Homo sapiens

-

enlarges the S1 pocket

647522