Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.21.35: tissue kallikrein

This is an abbreviated version!
For detailed information about tissue kallikrein, go to the full flat file.

Word Map on EC 3.4.21.35

Reaction

Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds =

Synonyms

bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, EMSP1, GK1, glandular kallikrein, glandular kallikrein 2, glandular kallikrein 24, glandular kallikrein-2, glumorin, HK1, hK10, hK11, hK13, hK14, hK3, hK5, hK6, hK8, HSCTE, HUK, K1, K2, Kailikang, Kal, kallidinogenase, kallikrein, kallikrein 1, kallikrein 24, kallikrein-related peptidase, kallikrein-related peptidase 10, kallikrein-related peptidase 2, kallikrein-related peptidase 7, kidney/pancreas/salivary gland kallikrein, kininogenase, kininogenin, KLK, KLK-L1 protein, KLK-L2 protein, KLK-L3, KLK-S3, KLK1, KLK10, KLK11, KLK15, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK9, mK1, mK13, mK22, mK24, mK9, More, neurosin, onokrein P., P1 kallikrein, padreatin, padutin, pancreatic kallikrein, pancreatic/renal kallikrein, PPK, Prk, pro-renin-converting enzyme, prokallikrein, prostase, prostase/KLK-L1/ARM1/PRSS17, prostate specific antigen, protease M, PS kallikrein, PSA, PSA/KLK3, renal kallikrein, renal tissue kallikrein, RSGK-50, RUK, S01.160, S1 kallikrein, S2 kallikrein, S3 kallikrein, salivary kallikrein, SEV, skeletal muscle kallikrein, submandibular enzymatic vasoconstrictor, T-kininogenase, tissue kallidinogenase, tissue kallikrein, tissue kallikrein 1, tissue kallikrein 11, tissue kallikrein 15, tissue kallikrein 4, tissue kallikrein 9, TK, trypsin-like serine protease, UKLK, urinary kallidinogenase, urinary kallikrein, urinary tissue kallikrein, urokallikrein, zyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.35 tissue kallikrein

Molecular Weight

Molecular Weight on EC 3.4.21.35 - tissue kallikrein

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11000
-
x * 11000 + x * 16000, kallikrein A, SDS-PAGE after reduction with 2-mercaptoethanol
14000
16000
18000
25200
-
equilibrium sedimentation
27000
-
x * 27000, kallikrein B, SDS-PAGE
28000
-
x * 28000, SDS-PAGE in absence of a reducing agent
29000
-
x * 29000, SDS-PAGE under reducing conditions
31000 - 35000
-
gel filtration
32000
33000
-
kallikrein B, gel filtration
33500
-
light scattering
34000
-
x * 34000 or x * 37000, the two molecular species represent differentially glycosylated forms
35000
-
x * 35000, SDS-PAGE
35900
-
prokallikrein A, gel filtration
36000
36500
-
1 * 36500, prokallikrein A, SDS-PAGE
37000
-
x * 34000 or x * 37000, the two molecular species represent differentially glycosylated forms
37400
-
prokallikrein B, gel filtration
38000
39000
40000
40500
-
short column equilibrium sedimentation
43000
-
x * 43000, urinary enzyme, SDS-PAGE
46000
-
1 * 46000, active kallikrein, SDS-PAGE
48000
-
1 * 48000, prokallikrein, SDS-PAGE
53000
-
prokallikrein and kallikrein, gel filtration
72000
-
unglycosylated dimer, SDS-PAGE
additional information
about 40% of human tissue kallikrein 11 (40000 Da) is enzymatically active, whereas the rest is inactivated by internal cleavage after Arg156 which generates two peptides of 20000 Da, connected by internal disulfide bonds