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Literature summary for 3.4.21.35 extracted from

  • Nakamura, S.; Morimoto, N.; Tsuruma, K.; Izuta, H.; Yasuda, Y.; Kato, N.; Ikeda, T.; Shimazawa, M.; Hara, H.
    Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165 (2011), Arterioscler. Thromb. Vasc. Biol., 31, 1041-1048.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vascular endothelial growth factor-165 + H2O Homo sapiens
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 ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
vitreous fluid
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vascular endothelial growth factor-165 + H2O
-
 Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function tissue kallikrein inhibits vascular endothelial growth factor-165-induced tube formation, proliferation, and migration in vitro angiogenesis model via suppression of the vascular endothelial growth factor-165-induced phosphorylation of vascular endothelial growth factor receptor-2. Tissue kallikrein is partly involved in pathogenesis of proliferative diabetic retinopathy Homo sapiens