1.1.1.67: mannitol 2-dehydrogenase

This is an abbreviated version, for detailed information about mannitol 2-dehydrogenase, go to the full flat file.

Reaction

D-mannitol
+
NAD+
=
D-fructose
+
NADH
+
H+

Synonyms

D-mannitol dehydrogenase, DSF1, Hxt13, Hxt15, Hxt16, Hxt17, M2DH, Man1, MAN2, mannitol 2-dehydrogenase, mannitol dehydrogenase, mannitol dehydrogenase 1, mannitol dehydrogenase 2, mannitol transporter, mannitol-2-dehydrogenase, MDH, mt-dh, MtDH, MtlD, NADH-dependent mannitol dehydrogenase, pfMDH, polyol dehydrogenase, PsM2DH, TM0298, YNR073C

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.67 mannitol 2-dehydrogenase

Reference

Reference on EC 1.1.1.67 - mannitol 2-dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hult, K.; Veide, A.; Gatenbeck, S.
The distribution of the NADPH regenerating mannitol cycle among fungal species
Arch. Microbiol.
128
253-255
1980
Fomes pinicola
Manually annotated by BRENDA team
Schmatz D.M.; Baginsky W.F.; Turner, M.J.
Evidence for and characterization of a mannitol cycle in Eimeria tenella
Mol. Biochem. Parasitol.
32
263-270
1989
Eimeria tenella
Manually annotated by BRENDA team
Sasajima, K.; Isono, M.
Polyol dehydrogenases in the soluble fraction of Acetobacter melanogenum
Agric. Biol. Chem.
32
161-169
1968
Gluconobacter oxydans
-
Manually annotated by BRENDA team
Schneider, K.H.; Giffhorn, F.
Purification and properties of a polyol dehydrogenase from the phototrophic bacterium Rhodobacter sphaeroides
Eur. J. Biochem.
184
15-19
1989
Rhodobacter sphaeroides
Manually annotated by BRENDA team
Quain, D.E.; Boulton, C.A.
Growth and metabolism of mannitol by strains of Saccharomyces cerevisiae
J. Gen. Microbiol.
133
1675-1684
1987
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Richter, D.F.E.; Kirst, G.O.
D-Mannitol dehydrogenase and D-mannitol-1-phosphate dehydrogenase in Platymonas subcordiformis: some characteristics and their role in osmotic adaptation
Planta
170
528-534
1987
Tetraselmis subcordiformis
Manually annotated by BRENDA team
Mori, M.; Shiio, I.
Pyruvate formation and sugar metabolism in an amino acid-producing bacterium, Brevibacterium flavum
Agric. Biol. Chem.
51
129-138
1987
Brevibacterium flavum, Brevibacterium flavum 2247
Manually annotated by BRENDA team
Kulbe, K.D.; Schwab, U.; Howaldt, M.; Kimmerle, K.
Anwendung von Membranverfahren bei der simultanen Herstellung von Mannitol und Gluconsäure aus Saccharose durch konjugierte NAD+-abhängige Dehydrogenasen
GBF Monogr.
9
189-200
1986
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Mathis, J.N.; Barbour, W.M.; Miller, T.B.; Israel, D.W.; Elkan, G.H.
Characterization of a mannitol-utilizing, nitrogen-fixing Bradyrhizobium japonicum USDA 110 derivative
Appl. Environ. Microbiol.
52
81-85
1986
Bradyrhizobium japonicum
Manually annotated by BRENDA team
Davis, C.L.; Robb, F.T.
Maintenance of different mannitol uptake systems during starvation in oxidative and fermentative marine bacteria
Appl. Environ. Microbiol.
50
743-748
1985
Pseudomonas sp.
Manually annotated by BRENDA team
Allenza, P.; Lee, Y.N.; Lessie, T.G.
Enzymes related to fructose utilization in Pseudomonas cepacia
J. Bacteriol.
150
1348-1356
1982
Burkholderia cepacia
Manually annotated by BRENDA team
Mulongoy, K.; Elkan, G.H.
Some effects of mannitol on the glucose metabolism of two derivatives of a strain of Rhizobium japonicum differing in mannitol dehydrogenase
Curr. Microbiol.
1
335-340
1978
Bradyrhizobium japonicum
-
Manually annotated by BRENDA team
Yamanaka, K.; Izawa, K.; Tenmizu, K.
Physicochemical properties of crystalline D-mannitol dehydrogenase of Leuconostoc mesenteroides
Agric. Biol. Chem.
41
1695-1699
1977
Leuconostoc mesenteroides
-
Manually annotated by BRENDA team
Mehta, R.J.; Fare, L.R.; Shearer, M.E.; Nash, C.H.
Mannitol oxidation in two Micromonospora isolates and in representative species of other actinomycetes
Appl. Environ. Microbiol.
33
1013-1015
1977
Actinoplanes missouriensis, Gluconobacter oxydans, Lactobacillus brevis, Mycobacterium smegmatis, Nocardia erythropolis, Sinorhizobium meliloti, Streptomyces lavendulae
Manually annotated by BRENDA team
Kuykendall, L.D.; Elkan, G.H.
Some features of mannitol metabolism in Rhizobium japonicum
J. Gen. Microbiol.
98
291-295
1977
Bradyrhizobium japonicum
Manually annotated by BRENDA team
Ueng, S.T.H.; McGuinness, E.T.
D-Mannitol dehydrogenase from Absidia glauca. Steady-state kinetic properties and the inhibitory role of mannitol 1-phosphate
Biochemistry
16
107-111
1977
Absidia glauca
Manually annotated by BRENDA team
Ueng, S.T.H.; Hartanowicz, P.; Lewandowski, C.; Keller, J.; M.Holick, E.T.McGuinness
D-Mannitol dehydrogenase from Absidia glauca. Purification, metabolic role, and subunit interactions
Biochemistry
15
1743-1749
1976
Absidia glauca
Manually annotated by BRENDA team
Yamanaka, K.
D-Mannitol dehydrogenase from Leuconostoc mesenteroides
Methods Enzymol.
41B
138-142
1975
Lactobacillus brevis, Lactobacillus gayonii, Lactobacillus pentoaceticus, Leuconostoc mesenteroides
Manually annotated by BRENDA team
Yamanaka, K.; Sakai, S.
Production of polyol dehydrogenases in bacteria
Can. J. Microbiol.
14
391-396
1968
Lactobacillus brevis, Lactobacillus gayonii, Lactobacillus pentoaceticus, Leuconostoc mesenteroides, Pseudomonas aeruginosa, Pseudomonas coronafaciens, Pseudomonas fluorescens, Sarcina aurantiaca, Sarcina marginata
Manually annotated by BRENDA team
Sakai, S.; Yamanaka, K.
Crystalline D-mannitol:NAD oxidoreductase from Leuconostoc mesenteroides: Part II. substrate and coenzyme specificity
Agric. Biol. Chem.
32
894-899
1968
Leuconostoc mesenteroides, no activity in Lactobacillus plantarum
-
Manually annotated by BRENDA team
Sakai, S.; Yamanaka, K.
Crystalline D-mannitol:NAD+ oxidoreductase from Leuconostoc mesenteroides
Biochim. Biophys. Acta
151
684-686
1968
Leuconostoc mesenteroides
Manually annotated by BRENDA team
Horecker, B.L.
Mannitol dehydrogenase (crystalline) from Lactobacillus brevis
Methods Enzymol.
9
143-146
1966
Lactobacillus brevis
-
Manually annotated by BRENDA team
Martinez, G.; Barker, H.A.; Horecker, B.L.
A specific mannitol dehydrogenase from Lactobacillus brevis
J. Biol. Chem.
238
1598-1603
1963
Lactobacillus brevis
-
Manually annotated by BRENDA team
Schafer, A.; Stein, M.A.; Schneider, K.H.; Giffhorn, F.
Mannitol dehydrogenase from Rhodobacter sphaeroides Si4: subcloning, overexpression in Escherichia coli and characterization of the recombinant enzyme
Appl. Microbiol. Biotechnol.
48
47-52
1997
Rhodobacter sphaeroides
Manually annotated by BRENDA team
Slatner, M.; Nagl, G.; Haltrich, D.; Kulbe, K.D.; Nidetzky, B.
Enzymic synthesis of mannitol: reaction engineering for a recombinant mannitol dehydrogenase
Ann. N. Y. Acad. Sci.
864
450-453
1998
Pseudomonas fluorescens
Manually annotated by BRENDA team
Slatner, M.; Nidetzky, B.; Kulbe, K.D.
Kinetic study of the catalytic mechanism of mannitol dehydrogenase from Pseudomonas fluorescens
Biochemistry
38
10489-10498
1999
Pseudomonas fluorescens
Manually annotated by BRENDA team
Brunker, P.; Altenbuchner, J.; Kulbe, K.D.; Mattes, R.
Cloning, nucleotide sequence and expression of a mannitol dehydrogenase gene from Pseudomonas fluorescens DSM 50106 in Escherichia coli
Biochim. Biophys. Acta
1351
157-167
1997
Pseudomonas fluorescens
Manually annotated by BRENDA team
Aarnikunnas, J.; Ronnholm, K.; Palva, A.
The mannitol dehydrogenase gene (mdh) from Leuconostoc mesenteroides is distinct from other known bacterial mdh genes
Appl. Microbiol. Biotechnol.
59
665-671
2002
Leuconostoc mesenteroides (Q8KQG6), Leuconostoc mesenteroides ATCC-9135 (Q8KQG6)
Manually annotated by BRENDA team
Kaup, B.; Bringer-Meyer, S.; Sahm, H.
Metabolic engineering of Escherichia coli: construction of an efficient biocatalyst for D-mannitol formation in a whole-cell biotransformation
Appl. Microbiol. Biotechnol.
64
333-339
2004
Leuconostoc pseudomesenteroides (Q83VI5)
Manually annotated by BRENDA team
Hahn, G.; Kaup, B.; Bringer-Meyer, S.; Sahm, H.
A zinc-containing mannitol-2-dehydrogenase from Leuconostoc pseudomesenteroides ATCC 12291: purification of the enzyme and cloning of the gene
Arch. Microbiol.
179
101-107
2003
Leuconostoc pseudomesenteroides (Q83VI5)
Manually annotated by BRENDA team
Klimacek, M.; Nidetzky, B.
A catalytic consensus motif for D-mannitol 2-dehydrogenase, a member of a polyol-specific long-chain dehydrogenase family, revealed by kinetic characterization of site-directed mutants of the enzyme from Pseudomonas fluorescens
Biochem. J.
367
13-18
2002
Pseudomonas fluorescens
Manually annotated by BRENDA team
Klimacek, M.; Kavanagh, K.L.; Wilson, D.K.; Nidetzky, B.
On the role of Bronsted catalysis in Pseudomonas fluorescens mannitol 2-dehydrogenase
Biochem. J.
375
141-149
2003
Pseudomonas fluorescens
Manually annotated by BRENDA team
Kavanagh, K.L.; Klimacek, M.; Nidetzky, B.; Wilson, D.K.
Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase: evidence for a very divergent long-chain dehydrogenase family
Chem. Biol. Interact.
143-144
551-558
2003
Pseudomonas fluorescens
Manually annotated by BRENDA team
Graefe, H.; Gutschow, B.; Gehring, H.; Dibbelt, L.
Sensitive and specific photometric determination of mannitol in human serum
Clin. Chem. Lab. Med.
41
1049-1055
2003
Leuconostoc mesenteroides
Manually annotated by BRENDA team
Korakli, M.; Vogel, R.F.
Purification and characterisation of mannitol dehydrogenase from Lactobacillus sanfranciscensis
FEMS Microbiol. Lett.
220
281-286
2003
Lactobacillus sanfranciscensis
Manually annotated by BRENDA team
Kavanagh, K.L.; Klimacek, M.; Nidetzky, B.; Wilson, D.K.
Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism
J. Biol. Chem.
277
43433-43442
2002
Pseudomonas fluorescens
Manually annotated by BRENDA team
Liu, S.; Saha, B.; Cotta, M.
Cloning, expression, purification, and analysis of mannitol dehydrogenase gene mtlK from Lactobacillus brevis
Appl. Biochem. Biotechnol.
121-124
391-401
2005
Lactobacillus brevis
Manually annotated by BRENDA team
Parmentier, S.; Arnaut, F.; Soetaert, W.; Vandamme, E.J.
Enzymatic production of D-mannitol with the Leuconostoc pseudomesenteroides mannitol dehydrogenase coupled to a coenzyme regeneration system
Biocatal. Biotransform.
23
1-7
2005
Leuconostoc pseudomesenteroides
-
Manually annotated by BRENDA team
Klimacek, M.; Nidetzky, B.
Examining the relative timing of hydrogen abstraction steps during NAD+-dependent oxidation of secondary alcohols catalyzed by long-chain D-mannitol dehydrogenase from Pseudomonas fluorescens using pH and kinetic isotope effects
Biochemistry
41
10158-10165
2002
Pseudomonas fluorescens
Manually annotated by BRENDA team
Parmentier, S.; Beauprez, J.; Arnaut, F.; Soetaert, W.; Vandamme, E.J.
Gluconobacter oxydans NAD-dependent, D-fructose reducing, polyol dehydrogenases activity: screening, medium optimisation and application for enzymatic polyol production
Biotechnol. Lett.
27
305-311
2005
Gluconobacter oxydans, Gluconobacter oxydans LMG 1489
Manually annotated by BRENDA team
Watanabe, Y.; Takechi, Y.; Nagayama, K.; Tamai, Y.
Overexpression of Saccharomyces cerevisiae mannitol dehydrogenase gene (YEL070w) in glycerol synthesis-deficient S. Cerevisiae mutant
Enzyme Microb. Technol.
39
654-659
2006
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Puttick, J.; Vieille, C.; Song, S.H.; Fodje, M.N.; Grochulski, P.; Delbaere, L.T.
Crystallization, preliminary X-ray diffraction and structure analysis of Thermotoga maritima mannitol dehydrogenase
Acta Crystallogr. Sect. F
63
350-352
2007
Thermotoga maritima
Manually annotated by BRENDA team
Baeumchen, C.; Roth, A.H.; Biedendieck, R.; Malten, M.; Follmann, M.; Sahm, H.; Bringer-Meyer, S.; Jahn, D.
D-mannitol production by resting state whole cell biotransformation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium
Biotechnol. J.
2
1408-1416
2007
Leuconostoc pseudomesenteroides (Q83VI5), Leuconostoc pseudomesenteroides ATCC12291 (Q83VI5)
Manually annotated by BRENDA team
Bubner, P.; Klimacek, M.; Nidetzky, B.
Structure-guided engineering of the coenzyme specificity of Pseudomonas fluorescens mannitol 2-dehydrogenase to enable efficient utilization of NAD(H) and NADP(H)
FEBS Lett.
582
233-237
2008
Pseudomonas fluorescens (O08355), Pseudomonas fluorescens
Manually annotated by BRENDA team
Song, S.H.; Ahluwalia, N.; Leduc, Y.; Delbaere, L.T.; Vieille, C.
Thermotoga maritima TM0298 is a highly thermostable mannitol dehydrogenase
Appl. Microbiol. Biotechnol.
81
485-495
2008
Lactobacillus reuteri (Q6ECH5), Thermotoga maritima (Q9WYD4), Thermotoga maritima
Manually annotated by BRENDA team
Krahulec, S.; Armao, G.C.; Bubner, P.; Klimacek, M.; Nidetzky, B.
Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies of mannitol 2-dehydrogenase and mannitol-1-phosphate 5-dehydrogenase
Chem. Biol. Interact.
178
274-282
2009
Aspergillus fumigatus, Aspergillus fumigatus (Q4WQY4)
Manually annotated by BRENDA team
Haghighatian, M.; Mofid, M.R.; Nekouei, M.K.; Yaghmaei, P.; Tafreshi, A.H.
Isomalt production by cloning, purifying and expressing of the MDH gene from Pseudomonas fluorescens DSM 50106 in different strains of E. coli
Pak. J. Biol. Sci.
11
2001-2006
2008
Pseudomonas fluorescens
Manually annotated by BRENDA team
Klimacek, M.; Nidetzky, B.
The oxyanion hole of Pseudomonas fluorescens mannitol 2-dehydrogenase: a novel structural motif for electrostatic stabilization in alcohol dehydrogenase active sites
Biochem. J.
425
455-463
2010
Pseudomonas fluorescens (O08355), Pseudomonas fluorescens
Manually annotated by BRENDA team
Klimacek, M.; Nidetzky, B.
From alcohol dehydrogenase to a 'one-way' carbonyl reductase by active-site redesign: a mechanistic study of mannitol 2-dehydrogenase from Pseudomonas fluorescens
J. Biol. Chem.
285
30644-30653
2010
Pseudomonas fluorescens (O08355), Pseudomonas fluorescens
Manually annotated by BRENDA team
Krahulec, S.; Armao, G.C.; Klimacek, M.; Nidetzky, B.
Enzymes of mannitol metabolism in the human pathogenic fungus Aspergillus fumigatus--kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications
FEBS J.
278
1264-1276
2011
Aspergillus fumigatus (Q4WQY4)
Manually annotated by BRENDA team
Klimacek, M.; Brunsteiner, M.; Nidetzky, B.
Dynamic mechanism of proton transfer in mannitol 2-dehydrogenase from Pseudomonas fluorescens: mobile GLU292 controls proton relay through a water channel that connects the active site with bulk solvent
J. Biol. Chem.
287
6655-6667
2012
Pseudomonas fluorescens (O08355), Pseudomonas fluorescens
Manually annotated by BRENDA team
Jordan, P.; Choe, J.Y.; Boles, E.; Oreb, M.
Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters
Sci. Rep.
6
0000
2016
Saccharomyces cerevisiae (P0CX08), Saccharomyces cerevisiae (P0CX09), Saccharomyces cerevisiae (P39924), Saccharomyces cerevisiae (P47185), Saccharomyces cerevisiae (P53631), Saccharomyces cerevisiae (P54854), Saccharomyces cerevisiae EBY.VW4000 (P0CX08), Saccharomyces cerevisiae EBY.VW4000 (P0CX09), Saccharomyces cerevisiae EBY.VW4000 (P39924), Saccharomyces cerevisiae EBY.VW4000 (P47185), Saccharomyces cerevisiae EBY.VW4000 (P53631), Saccharomyces cerevisiae EBY.VW4000 (P54854)
Manually annotated by BRENDA team