1.1.1.67: mannitol 2-dehydrogenase

This is an abbreviated version, for detailed information about mannitol 2-dehydrogenase, go to the full flat file.

Reaction

D-mannitol
+
NAD+
=
D-fructose
+
NADH
+
H+

Synonyms

D-mannitol dehydrogenase, DSF1, Hxt13, Hxt15, Hxt16, Hxt17, M2DH, Man1, MAN2, mannitol 2-dehydrogenase, mannitol dehydrogenase, mannitol dehydrogenase 1, mannitol dehydrogenase 2, mannitol transporter, mannitol-2-dehydrogenase, MDH, mt-dh, MtDH, MtlD, NADH-dependent mannitol dehydrogenase, pfMDH, polyol dehydrogenase, PsM2DH, TM0298, YNR073C

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.67 mannitol 2-dehydrogenase

KM Value

KM Value on EC 1.1.1.67 - mannitol 2-dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8 - 163
D-arabinitol
1.6 - 6.5
D-arabitol
0.24 - 79.2
D-fructose
32
D-glucitol
-
-
0.29 - 1187
D-mannitol
58.5
D-sorbitol
-
recombinant protein
1.7
D-xylulose
-
pH 7.1, 25°C
680
L-sorbitol
-
pH 10.0, 25°C
0.001 - 0.775
NAD+
0.0033 - 0.15
NADH
7.5
NADP+
at 80°C and pH 8.3; at 80°C, pH 8.3
0.17
NADPH
at 80°C and pH 6.1; at 80°C, pH 6.1
0.1
polyethyleneglycol-NH-succinyl-aminoethyl-NADH
-
-
-
0.125
polyethyleneglycol-NH-succinyl-NADH
-
-
-
0.074
polyethylenimine-NH-succinyl-NADH
-
-
-
additional information
additional information
-
steady-state kinetic analysis, recombinant wild-type and mutant enzymes, overview
-