BRENDA - Enzyme Database show
show all sequences of 1.1.1.67

Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies of mannitol 2-dehydrogenase and mannitol-1-phosphate 5-dehydrogenase

Krahulec, S.; Armao, G.C.; Bubner, P.; Klimacek, M.; Nidetzky, B.; Chem. Biol. Interact. 178, 274-282 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli JM109 cells
Aspergillus fumigatus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.019
-
NADH
at 25C, in 100 mM Tris/HCl buffer, pH 7.1
Aspergillus fumigatus
0.15
-
NAD+
at 25C, in 100 mM glycine/NaOH buffer pH 10.0
Aspergillus fumigatus
13
-
D-mannitol
at 25C, in 100 mM glycine/NaOH buffer pH 10.0
Aspergillus fumigatus
60
-
D-fructose
at 25C, in 100 mM Tris/HCl buffer, pH 7.1
Aspergillus fumigatus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
does not require metals for activity
Aspergillus fumigatus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
58000
-
recombinant enzyme, SDS-PAGE
Aspergillus fumigatus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aspergillus fumigatus
Q4WQY4
-
-
Purification (Commentary)
Commentary
Organism
Co2+ chelating Sepharose column chromatography and Superdex 200 gel filtration
Aspergillus fumigatus
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
14
-
crude extract, at 25C, using 100 mM Tris-HCl buffer, pH 7.1
Aspergillus fumigatus
33
-
after 6.7fold purification, at 25C, using 100 mM Tris-HCl buffer, pH 7.1
Aspergillus fumigatus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-mannitol + NAD+
-
697276
Aspergillus fumigatus
D-fructose + NADH + H+
-
-
-
r
D-mannitol + NADP+
M2DH is a much poorer enzyme when it employes NADP+ and NADPH as compared to NAD+ and NADH
697276
Aspergillus fumigatus
D-fructose + NADPH + H+
-
-
-
r
Subunits
Subunits
Commentary
Organism
monomer
1 * 58000, recombinant enzyme, SDS-PAGE
Aspergillus fumigatus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6
10
-
Aspergillus fumigatus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
dependent on, M2DH is a much poorer enzyme when it employes NADP+ and NADPH as compared to NAD+ and NADH
Aspergillus fumigatus
NADP+
M2DH is a much poorer enzyme when it employes NADP+ and NADPH as compared to NAD+ and NADH
Aspergillus fumigatus
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli JM109 cells
Aspergillus fumigatus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
dependent on, M2DH is a much poorer enzyme when it employes NADP+ and NADPH as compared to NAD+ and NADH
Aspergillus fumigatus
NADP+
M2DH is a much poorer enzyme when it employes NADP+ and NADPH as compared to NAD+ and NADH
Aspergillus fumigatus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.019
-
NADH
at 25C, in 100 mM Tris/HCl buffer, pH 7.1
Aspergillus fumigatus
0.15
-
NAD+
at 25C, in 100 mM glycine/NaOH buffer pH 10.0
Aspergillus fumigatus
13
-
D-mannitol
at 25C, in 100 mM glycine/NaOH buffer pH 10.0
Aspergillus fumigatus
60
-
D-fructose
at 25C, in 100 mM Tris/HCl buffer, pH 7.1
Aspergillus fumigatus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
does not require metals for activity
Aspergillus fumigatus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
58000
-
recombinant enzyme, SDS-PAGE
Aspergillus fumigatus
Purification (Commentary) (protein specific)
Commentary
Organism
Co2+ chelating Sepharose column chromatography and Superdex 200 gel filtration
Aspergillus fumigatus
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
14
-
crude extract, at 25C, using 100 mM Tris-HCl buffer, pH 7.1
Aspergillus fumigatus
33
-
after 6.7fold purification, at 25C, using 100 mM Tris-HCl buffer, pH 7.1
Aspergillus fumigatus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-mannitol + NAD+
-
697276
Aspergillus fumigatus
D-fructose + NADH + H+
-
-
-
r
D-mannitol + NADP+
M2DH is a much poorer enzyme when it employes NADP+ and NADPH as compared to NAD+ and NADH
697276
Aspergillus fumigatus
D-fructose + NADPH + H+
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 58000, recombinant enzyme, SDS-PAGE
Aspergillus fumigatus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6
10
-
Aspergillus fumigatus
Other publictions for EC 1.1.1.67
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737257
Jordan
Hxt13, Hxt15, Hxt16 and Hxt17 ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae EBY.VW4000
Sci. Rep.
6
0000
2016
-
-
-
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-
-
-
2
-
-
-
16
-
12
-
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19
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2
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16
-
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-
19
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725508
Klimacek
Dynamic mechanism of proton tr ...
Pseudomonas fluorescens
J. Biol. Chem.
287
6655-6667
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-
-
-
-
1
-
-
-
-
-
-
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-
3
-
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-
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2
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1
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2
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-
722234
Krahulec
Enzymes of mannitol metabolism ...
Aspergillus fumigatus
FEBS J.
278
1264-1276
2011
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-
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2
7
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2
-
2
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-
1
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-
7
-
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-
2
5
-
-
-
3
4
-
-
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-
3
-
-
-
-
2
4
7
-
-
-
2
-
-
-
-
-
-
-
-
7
-
-
-
2
5
-
-
-
-
-
-
-
-
6
6
711136
Klimacek
The oxyanion hole of Pseudomon ...
Pseudomonas fluorescens
Biochem. J.
425
455-463
2010
-
-
-
-
3
-
-
16
-
-
-
-
-
2
-
-
-
1
-
-
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-
2
-
-
-
-
8
-
-
-
-
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-
-
-
-
-
-
-
3
-
-
-
-
16
-
-
-
-
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-
-
-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
-
-
-
16
16
712470
Klimacek
From alcohol dehydrogenase to ...
Pseudomonas fluorescens
J. Biol. Chem.
285
30644-30653
2010
-
-
1
-
3
-
2
22
-
-
1
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
11
-
-
-
2
6
-
-
-
-
1
2
-
3
-
-
2
6
22
-
-
1
-
-
-
-
-
-
-
-
-
2
1
-
-
-
11
-
-
-
-
-
-
-
-
21
21
697276
Krahulec
Polyol-specific long-chain deh ...
Aspergillus fumigatus
Chem. Biol. Interact.
178
274-282
2009
-
-
1
-
-
-
-
4
-
1
1
-
-
5
-
-
1
-
-
-
2
-
2
1
-
-
-
-
-
1
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
4
-
1
1
-
-
-
-
1
-
-
2
-
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
686764
Bubner
Structure-guided engineering o ...
Pseudomonas fluorescens
FEBS Lett.
582
233-237
2008
1
1
1
-
3
-
1
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
1
-
-
6
1
-
-
3
-
-
-
1
1
1
3
-
3
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
6
1
-
-
-
-
-
-
-
-
-
695814
Song
Thermotoga maritima TM0298 is ...
Lactobacillus reuteri, Thermotoga maritima
Appl. Microbiol. Biotechnol.
81
485-495
2008
-
-
2
-
-
-
2
9
-
4
4
-
-
5
-
-
1
-
-
-
1
-
11
4
2
2
2
-
3
-
1
4
1
-
-
-
-
2
4
-
-
-
-
2
1
9
-
4
4
-
-
-
-
1
-
-
1
-
11
4
2
2
2
-
3
-
1
-
-
-
-
-
-
-
700553
Haghighatian
Isomalt production by cloning, ...
Pseudomonas fluorescens
Pak. J. Biol. Sci.
11
2001-2006
2008
-
1
1
-
-
-
-
-
-
-
1
-
-
3
-
-
1
-
-
-
1
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5
1
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-
-
-
-
-
-
-
-
1
1
-
-
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-
-
-
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-
1
-
-
-
-
1
-
-
1
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684173
Puttick
Crystallization, preliminary X ...
Thermotoga maritima
Acta Crystallogr. Sect. F
63
350-352
2007
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
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1
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1
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1
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-
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-
-
-
-
-
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685726
Baeumchen
D-mannitol production by resti ...
Leuconostoc pseudomesenteroides, Leuconostoc pseudomesenteroides ATCC12291
Biotechnol. J.
2
1408-1416
2007
-
1
1
-
1
-
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1
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2
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2
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1
1
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1
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1
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-
2
-
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-
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668450
Watanabe
-
Overexpression of Saccharomyce ...
Saccharomyces cerevisiae
Enzyme Microb. Technol.
39
654-659
2006
-
-
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1
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1
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1
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2
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1
-
1
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-
-
2
-
-
-
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-
-
-
-
667238
Liu
Cloning, expression, purificat ...
Lactobacillus brevis
Appl. Biochem. Biotechnol.
121-124
391-401
2005
-
-
1
-
-
-
-
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1
-
-
5
-
-
1
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1
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1
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-
1
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1
1
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1
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1
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1
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1
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-
-
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-
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667367
Parmentier
-
Enzymatic production of D-mann ...
Leuconostoc pseudomesenteroides
Biocatal. Biotransform.
23
1-7
2005
-
-
-
-
-
-
-
-
-
-
1
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1
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2
-
2
-
1
-
2
1
-
2
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2
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1
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2
-
2
-
1
-
2
1
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668058
Parmentier
Gluconobacter oxydans NAD-depe ...
Gluconobacter oxydans, Gluconobacter oxydans LMG 1489
Biotechnol. Lett.
27
305-311
2005
2
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2
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2
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2
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1
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1
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2
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2
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1
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1
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654309
Kaup
Metabolic engineering of Esche ...
Leuconostoc pseudomesenteroides
Appl. Microbiol. Biotechnol.
64
333-339
2004
-
1
1
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1
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1
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1
1
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1
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654390
Hahn
A zinc-containing mannitol-2-d ...
Leuconostoc pseudomesenteroides
Arch. Microbiol.
179
101-107
2003
-
-
1
-
-
1
3
2
-
1
2
-
-
4
-
-
1
-
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-
1
1
3
1
-
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-
-
2
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3
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1
3
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1
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3
-
2
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1
2
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1
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1
1
3
1
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2
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654531
Klimacek
On the role of Bronsted cataly ...
Pseudomonas fluorescens
Biochem. J.
375
141-149
2003
-
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2
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2
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1
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2
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1
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-
-
-
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655223
Kavanagh
Crystal structure of Pseudomon ...
Pseudomonas fluorescens
Chem. Biol. Interact.
143-144
551-558
2003
-
-
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1
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-
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-
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2
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1
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655244
Graefe
Sensitive and specific photome ...
Leuconostoc mesenteroides
Clin. Chem. Lab. Med.
41
1049-1055
2003
-
1
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2
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1
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655617
Korakli
Purification and characterisat ...
Lactobacillus sanfranciscensis
FEMS Microbiol. Lett.
220
281-286
2003
1
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654295
Aarnikunnas
The mannitol dehydrogenase gen ...
Leuconostoc mesenteroides, Leuconostoc mesenteroides ATCC-9135
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665-671
2002
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654504
Klimacek
A catalytic consensus motif fo ...
Pseudomonas fluorescens
Biochem. J.
367
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2002
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656092
Kavanagh
Crystal structure of Pseudomon ...
Pseudomonas fluorescens
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277
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2002
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667571
Klimacek
Examining the relative timing ...
Pseudomonas fluorescens
Biochemistry
41
10158-10165
2002
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4
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287261
Slatner
Kinetic study of the catalytic ...
Pseudomonas fluorescens
Biochemistry
38
10489-10498
1999
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2
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287260
Slatner
Enzymic synthesis of mannitol: ...
Pseudomonas fluorescens
Ann. N. Y. Acad. Sci.
864
450-453
1998
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1
1
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287259
Schafer
Mannitol dehydrogenase from Rh ...
Rhodobacter sphaeroides
Appl. Microbiol. Biotechnol.
48
47-52
1997
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287262
Brunker
Cloning, nucleotide sequence a ...
Pseudomonas fluorescens
Biochim. Biophys. Acta
1351
157-167
1997
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94720
Schmatz D.M.; Baginsky W.F.; Turner
Evidence for and characterizat ...
Eimeria tenella
Mol. Biochem. Parasitol.
32
263-270
1989
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2
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5
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1
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1
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1
1
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287237
Schneider
Purification and properties of ...
Rhodobacter sphaeroides
Eur. J. Biochem.
184
15-19
1989
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6
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2
1
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6
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1
1
5
1
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1
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2
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287238
Quain
Growth and metabolism of manni ...
Saccharomyces cerevisiae
J. Gen. Microbiol.
133
1675-1684
1987
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2
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287239
Richter
D-Mannitol dehydrogenase and D ...
Tetraselmis subcordiformis
Planta
170
528-534
1987
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2
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2
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-
-
287240
Mori
Pyruvate formation and sugar m ...
Brevibacterium flavum, Brevibacterium flavum 2247
Agric. Biol. Chem.
51
129-138
1987
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4
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4
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2
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287241
Kulbe
-
Anwendung von Membranverfahren ...
Saccharomyces cerevisiae
GBF Monogr.
9
189-200
1986
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1
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1
4
5
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1
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1
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5
1
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2
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1
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-
-
-
287242
Mathis
Characterization of a mannitol ...
Bradyrhizobium japonicum
Appl. Environ. Microbiol.
52
81-85
1986
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2
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287243
Davis
Maintenance of different manni ...
Pseudomonas sp.
Appl. Environ. Microbiol.
50
743-748
1985
-
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1
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287244
Allenza
Enzymes related to fructose ut ...
Burkholderia cepacia
J. Bacteriol.
150
1348-1356
1982
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94717
Hult
The distribution of the NADPH ...
Fomes pinicola
Arch. Microbiol.
128
253-255
1980
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2
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-
287246
Mulongoy
-
Some effects of mannitol on th ...
Bradyrhizobium japonicum
Curr. Microbiol.
1
335-340
1978
-
-
-
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1
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3
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-
287247
Yamanaka
-
Physicochemical properties of ...
Leuconostoc mesenteroides
Agric. Biol. Chem.
41
1695-1699
1977
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1
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2
1
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1
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2
1
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287248
Mehta
Mannitol oxidation in two Micr ...
Actinoplanes missouriensis, Gluconobacter oxydans, Lactobacillus brevis, Mycobacterium smegmatis, Nocardia erythropolis, Sinorhizobium meliloti, Streptomyces lavendulae
Appl. Environ. Microbiol.
33
1013-1015
1977
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-
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7
-
7
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14
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14
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14
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7
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14
-
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-
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287249
Kuykendall
Some features of mannitol meta ...
Bradyrhizobium japonicum
J. Gen. Microbiol.
98
291-295
1977
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3
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5
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287250
Ueng
D-Mannitol dehydrogenase from ...
Absidia glauca
Biochemistry
16
107-111
1977
-
-
-
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1
4
-
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1
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1
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2
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1
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4
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2
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1
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-
-
-
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287251
Ueng
D-Mannitol dehydrogenase from ...
Absidia glauca
Biochemistry
15
1743-1749
1976
-
-
-
-
-
-
2
-
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-
2
1
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2
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1
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1
1
3
1
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-
1
-
2
1
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2
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2
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2
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2
1
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1
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1
1
3
1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
287252
Yamanaka
D-Mannitol dehydrogenase from ...
Lactobacillus brevis, Lactobacillus gayonii, Lactobacillus pentoaceticus, Leuconostoc mesenteroides
Methods Enzymol.
41B
138-142
1975
-
-
-
1
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-
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9
-
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1
4
-
4
-
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1
-
-
1
1
-
8
-
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4
-
2
8
-
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-
8
1
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-
-
9
-
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1
4
-
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1
-
1
1
-
8
-
-
-
-
-
4
-
2
-
-
-
-
-
-
-
285866
Sasajima
-
Polyol dehydrogenases in the s ...
Gluconobacter oxydans
Agric. Biol. Chem.
32
161-169
1968
-
-
-
-
-
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3
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1
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1
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1
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1
1
2
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1
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2
2
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2
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2
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3
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1
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1
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1
1
2
-
-
-
1
-
2
2
-
-
-
-
-
-
-
-
287253
Yamanaka
Production of polyol dehydroge ...
Lactobacillus brevis, Lactobacillus gayonii, Lactobacillus pentoaceticus, Leuconostoc mesenteroides, Pseudomonas aeruginosa, Pseudomonas coronafaciens, Pseudomonas fluorescens, Sarcina aurantiaca, Sarcina marginata
Can. J. Microbiol.
14
391-396
1968
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9
-
9
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18
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18
-
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18
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9
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-
18
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
287255
Sakai
-
Crystalline D-mannitol:NAD oxi ...
Leuconostoc mesenteroides, no activity in Lactobacillus plantarum
Agric. Biol. Chem.
32
894-899
1968
-
-
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1
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1
4
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1
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2
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3
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2
2
2
2
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2
1
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1
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4
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1
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3
-
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2
2
2
-
-
-
-
-
-
-
287256
Sakai
Crystalline D-mannitol:NAD+ ox ...
Leuconostoc mesenteroides
Biochim. Biophys. Acta
151
684-686
1968
-
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1
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1
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1
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1
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1
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2
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2
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2
1
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1
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-
1
-
1
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2
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Mannitol dehydrogenase (crysta ...
Lactobacillus brevis
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143-146
1966
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287258
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A specific mannitol dehydrogen ...
Lactobacillus brevis
J. Biol. Chem.
238
1598-1603
1963
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