1.1.1.67: mannitol 2-dehydrogenase

This is an abbreviated version, for detailed information about mannitol 2-dehydrogenase, go to the full flat file.

Reaction

D-mannitol
+
NAD+
=
D-fructose
+
NADH
+
H+

Synonyms

D-mannitol dehydrogenase, DSF1, Hxt13, Hxt15, Hxt16, Hxt17, M2DH, Man1, MAN2, mannitol 2-dehydrogenase, mannitol dehydrogenase, mannitol dehydrogenase 1, mannitol dehydrogenase 2, mannitol transporter, mannitol-2-dehydrogenase, MDH, mt-dh, MtDH, MtlD, NADH-dependent mannitol dehydrogenase, pfMDH, polyol dehydrogenase, PsM2DH, TM0298, YNR073C

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.67 mannitol 2-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.67 - mannitol 2-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
citrate
-
50 mM, pH 5.4, 72% inhibition
Cu2+
-
1 mM, 61% inhibition
CuSO4
-
1 mM, 28% inhibition of D-fructose reduction, 18% inhibition of D-sorbitol oxidation
D-fructose
-
substrate inhibition, Ki: 1.356 mM
D-mannitol
-
product inhibition, Ki: 24.6 mM
FeCl2
-
10 mM, 88% inhibition
imidazole
-
175 mM,pH 7.0, 74% inhibition
L-sorbitol
-
Ki: 24.6 mM
mannitol 1-phosphate
-
-
Methyl mercurinitrate
-
complete inhibition
MnCl2
-
10 mM, 48% inhibition
NaCl
-
with increasing NaCl concentrations enzyme activity decreases, 1.5 M NaCl 74% inhibition for oxidation and 72% inhibition for reduction
p-chloromercuribenzoate
-
0.1 mM, 100% inhibition
p-hydroxymercuribenzoate
PCMB
0.1 mM, complete inhibition
Zn2+
-
1 mM, 94% inhibition
ZnCl2
-
10 mM, 60% inhibition
additional information
-