1.1.1.47: glucose 1-dehydrogenase [NAD(P)+]

This is an abbreviated version, for detailed information about glucose 1-dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

D-glucose
+
NAD(P)+
=
D-glucono-1,5-lactone
+
NAD(P)H
+
H+

Synonyms

alkali-resistant glucose 1-dehydrogenase, beta-D-glucose:NAD(P)+ 1-oxido-reductase, beta-D-glucose:NAD(P)+ 1-oxidoreductase, BmGlcDH-III, BmGlcDH-IV, D-glucose dehydrogenase (NAD(P)), EC 1.1.5.2, GDH, gdh-2, general stress protein 74, GlcDH, GlcDH-I, GlcDH-II, GlcDH-IWG3, glucose 1-dehydrogenase, glucose 1-dehydrogenase 3, glucose 1-dehydrogenase III, glucose 1-dehydrogenase IV, glucose dehydrogenase, glucose1-dehydrogenase, GSP74, hexose phosphate dehydrogenase, hexose-6-phosphate dehydrogenase, LsGDH, More, NAD(P)-dependent glucose-1-dehydrogenase, NAD-GDH, nicotinamide adenine dinucleotide (NAD)-linked glucose dehydrogenase, SsGDH, SSO3204

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]

Substrates Products

Substrates Products on EC 1.1.1.47 - glucose 1-dehydrogenase [NAD(P)+]

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-amino-2-deoxy-D-glucose + NAD(P)+
?
show the reaction diagram
2-amino-2-deoxy-D-glucose + NAD+
2-amino-2-deoxy-D-glucono-1,5-lactone + NADH + H+
show the reaction diagram
2-amino-2-deoxy-D-glucose + NADP+
2-amino-2-deoxy-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
-
5% of the activity with D-glucose and NAD+
-
-
?
2-deoxy-D-glucose + NAD(P)+
?
show the reaction diagram
2-deoxy-D-glucose + NAD+
2-deoxy-D-glucono-1,5-lactone + NADH + H+
show the reaction diagram
2-deoxy-D-glucose + NAD+
?
show the reaction diagram
2-deoxy-D-glucose + NADP+
2-deoxy-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
2-deoxy-D-glucose 6-phosphate + NAD+
2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADH
show the reaction diagram
-
-
-
-
?
2-deoxy-D-glucose 6-phosphate + NADP+
2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADPH
show the reaction diagram
-
-
-
-
?
6-deoxy-D-glucose + NAD(P)+
?
show the reaction diagram
6-deoxy-D-glucose + NAD+
6-deoxy-D-glucono-1,5-lactone + NADH + H+
show the reaction diagram
-
66% of the activity with D-glucose
-
-
?
6-deoxy-D-glucose + NADP+
? + NADPH
show the reaction diagram
-
9% of the activity with D-glucose and NAD+
-
-
?
beta-D-galactose + NADP+
D-galactono-1,5-lactone + NADPH
show the reaction diagram
beta-D-galactose + NADP+
D-galactono-1,5-lactone + NADPH + H+
show the reaction diagram
-
-
-
-
?
beta-D-glucose + 2,6-dichlorophenol-indophenol
?
show the reaction diagram
beta-D-glucose + NAD(P)(+)
D-glucono-1,5-lactone + NAD(P)H
show the reaction diagram
the enzyme might represent the major player in glucose catabolism via the branched Entner-Doudoroff pathway
-
-
ir
beta-D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
show the reaction diagram
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH
show the reaction diagram
the enzyme is absolutely specific for glucose. D-Galactose, D-allose, D-mannose, D-xylose, L-arabinose, D-ribose, D-xylose, D-arabinose, L-xylose, D-glucosamine, 2-deoxy-D-glucose, D-fucose, D-lactose, D-maltose, D-fructose and ethanol are not used as substrates. the catalytic efficiency for the reaction with beta-D-glucose and NADP+ (kcat/Km) is 7.8 fold higher compared to catalytic efficiency for the reaction with beta-D-glucose and NAD+
-
-
ir
beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
show the reaction diagram
beta-D-glucose + NADP+
D-glucono-1,5-lactone + NADPH
show the reaction diagram
the enzyme is absolutely specific for glucose. D-Galactose, D-allose, D-mannose, D-xylose, L-arabinose, D-ribose, D-xylose, D-arabinose, L-xylose, D-glucosamine, 2-deoxy-D-glucose, D-fucose, D-lactose, D-maltose, D-fructose and ethanol are not used as substrates. the catalytic efficiency for the reaction with beta-D-glucose and NADP+ (kcat/Km) is 7.8 fold higher compared to catalytic efficiency for the reaction with beta-D-glucose and NAD+
-
-
ir
beta-D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
beta-D-glucose 6-phosphate + NAD+
D-glucono-1,5-lactone 6-phosphate + NADPH
show the reaction diagram
-
-
-
-
?
beta-D-glucose 6-phosphate + NADP+
D-glucono-1,5-lactone 6-phosphate + NADPH
show the reaction diagram
cellobiose + NAD+
? + NADH
show the reaction diagram
D-allose + NAD(P)+
?
show the reaction diagram
-
low activity
-
-
?
D-allose + NAD+
D-allono-1,5-lactone + NADH
show the reaction diagram
-
8% of the activity with D-glucose
-
-
?
D-allose + NADP+
D-allono-1,5-lactone + NADPH
show the reaction diagram
-
13% of the activity with D-glucose and NAD+
-
-
?
D-altrose + NAD+
D-altrono-1,5-lactone + NADH
show the reaction diagram
-
5% of the activity with D-glucose
-
-
?
D-altrose + NADP+
?
show the reaction diagram
-
low activity
-
-
?
D-altrose + NADP+
D-altrono-1,5-lactone + NADPH
show the reaction diagram
-
12% of the activity with D-glucose and NAD+
-
-
?
D-cellobiose + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
D-fructose + NAD(P)+
? + NAD(P)H
show the reaction diagram
-
no activity with mutants Q252L and Q252L/E170K
-
-
?
D-fructose + NAD+
?
show the reaction diagram
D-fructose + NAD+
? + NADH
show the reaction diagram
D-fucose + NAD(P)+
?
show the reaction diagram
-
-
-
?
D-galactose + NAD(P)+
D-galactono-1,5-lactone + NAD(P)H
show the reaction diagram
D-galactose + NAD+
?
show the reaction diagram
D-galactose + NAD+
D-galactono-1,5-lactone + NADH
show the reaction diagram
D-galactose + NAD+
D-galactono-1,5-lactone + NADH + H+
show the reaction diagram
D-galactose + NADP+
D-galactono-1,5-lactone + NADPH
show the reaction diagram
D-glucosamine + NAD(P)+
?
show the reaction diagram
low activity
-
-
?
D-glucosamine + NAD+
?
show the reaction diagram
-
-
-
?
D-glucosamine + NAD+
D-glucosamino-1,5-lactone + NADH
show the reaction diagram
D-glucosamine + NAD+
D-glucosamino-1,5-lactone + NADH + H+
show the reaction diagram
D-glucosamine + NADP+
D-glucosamino-1,5-lactone + NADPH
show the reaction diagram
-
-
-
-
?
D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H
show the reaction diagram
D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
show the reaction diagram
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH
show the reaction diagram
-
-
-
?
D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NADP+
D-glucono-1,5-lactone 6-phosphate + NADPH + H+
show the reaction diagram
D-gulose + NAD(P)+
?
show the reaction diagram
-
low activity
-
-
?
D-gulose + NAD+
D-gulono-1,5-lactone + NADH
show the reaction diagram
-
8% of the activity with D-glucose
-
-
?
D-gulose + NADP+
D-gulono-1,5-lactone + NADPH
show the reaction diagram
-
12% of the activity with D-glucose and NAD+
-
-
?
D-idose + NAD(P)+
?
show the reaction diagram
low activity
-
-
?
D-idose + NAD+
D-idono-1,5-lactone + NADH
show the reaction diagram
-
65% of the activity with D-glucose
-
-
?
D-idose + NADP+
D-idono-1,5-lactone + NADPH
show the reaction diagram
-
12% of the activity with D-glucose and NAD+
-
-
?
D-lactose + NAD+
D-lactono-1,5-lactone + NADH + H+
show the reaction diagram
relative activity: 4.2%
-
-
?
D-lyxose + NAD(P)+
?
show the reaction diagram
low activity
-
-
?
D-maltose + NAD(P)+
? + NAD(P)H
show the reaction diagram
D-maltose + NAD+
?
show the reaction diagram
relative activity: 22.4%
-
-
?
D-mannose + NAD(P)+
? + NAD(P)H
show the reaction diagram
D-mannose + NAD+
?
show the reaction diagram
weak substrate
-
-
?
D-mannose + NAD+
D-mannono-1,5-lactone + NADH
show the reaction diagram
D-mannose + NAD+
D-mannono-1,5-lactone + NADH + H+
show the reaction diagram
D-mannose + NADP+
D-mannono-1,5-lactone + NADPH
show the reaction diagram
D-ribose + NADP+
?
show the reaction diagram
D-ribose + NADP+
D-ribono-1,5-lactone + NADPH
show the reaction diagram
-
4% of the activity with D-glucose and NADP+
-
-
?
D-xylose + NAD(P)+
?
show the reaction diagram
D-xylose + NAD(P)+
D-xylono-1,5-lactone + NAD(P)H + H+
show the reaction diagram
D-xylose + NAD+
?
show the reaction diagram
weak substrate
-
-
?
D-xylose + NAD+
D-xylono-1,5-lactone + NADH + H+
show the reaction diagram
D-xylose + NADP+
D-xylono-1,5-lactone + NADPH + H+
show the reaction diagram
gentiobiose + NAD+
? + NADH
show the reaction diagram
gluconate + NAD+
? + NADH
show the reaction diagram
L-arabinose + NAD(P)+
?
show the reaction diagram
maltose + NAD+
? + NADH
show the reaction diagram
maltose + NADP+
? + NADPH
show the reaction diagram
sucrose + NAD+
?
show the reaction diagram
relative activity: 6.3%
-
-
?
additional information
?
-