1.1.1.47: glucose 1-dehydrogenase [NAD(P)+]

This is an abbreviated version, for detailed information about glucose 1-dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

D-glucose
+
NAD(P)+
=
D-glucono-1,5-lactone
+
NAD(P)H
+
H+

Synonyms

alkali-resistant glucose 1-dehydrogenase, beta-D-glucose:NAD(P)+ 1-oxido-reductase, beta-D-glucose:NAD(P)+ 1-oxidoreductase, BmGlcDH-III, BmGlcDH-IV, D-glucose dehydrogenase (NAD(P)), EC 1.1.5.2, GDH, gdh-2, general stress protein 74, GlcDH, GlcDH-I, GlcDH-II, GlcDH-IWG3, glucose 1-dehydrogenase, glucose 1-dehydrogenase 3, glucose 1-dehydrogenase III, glucose 1-dehydrogenase IV, glucose dehydrogenase, glucose1-dehydrogenase, GSP74, hexose phosphate dehydrogenase, hexose-6-phosphate dehydrogenase, LsGDH, More, NAD(P)-dependent glucose-1-dehydrogenase, NAD-GDH, nicotinamide adenine dinucleotide (NAD)-linked glucose dehydrogenase, SsGDH, SSO3204

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]

Inhibitors

Inhibitors on EC 1.1.1.47 - glucose 1-dehydrogenase [NAD(P)+]

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
1 M, 71% inhibition
2-mercaptoethanol
-
1 mM, room temperature, pH 9.0, rapid inactivation
3-(2-bromoacetyl)pyridine
-
active-site-directed irreverseible inhibitor, the cofactor NAD but not the substrate glucose protects the enzyme from the inactivation, in the presence of 0.1 M NAD and 1.37 mM 3-(2-bromoacetyl)pyridine, glucose dehydrogenase has still 85% of its original activity after incubation for 2 h
5,5'-dithiobis(2-nitrobenzoic acid)
-
1 mM, room temperature, pH 9.0, 50% inactivation
Ag+
-
1 mM, 99% inhibition
Cd2+
more than 50% inhibition at 20 mM
D-glucono-1,5-lactone
-
forward reaction, oxidation, product inhibition, noncompetitive vs. beta-D-glucose and NADP+
dithiothreitol
-
10 mM, 28% inhibition
KCl
-
1 M, 44% inhibition
LiCl
-
1 M, 64% inhibition
N-ethylmaleimide
-
3 mM, room temperature, pH 9.0, 50% inactivation
NAD+
-
above 12 mM
NADH
-
0.1 mM, 45% inhibition, noncompetitive inhibitorr of D-glucose
NADP+
NADPH
p-chloromercuribenzoate
-
1 mM, 93% inhibition
Tetranitromethane
-
the rapid inactivation can be prevented by the presence of NAD, AMP, or ATP
thioredoxin
-
in the presence of 0.5 mM dithiothreitol
additional information
-