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Information on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter

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IUBMB Comments
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
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The enzyme appears in viruses and cellular organisms
Synonyms
ABCC1, ABCC2, ABCC3, ABCC4, Abcc5, ABCG2, ATP-dependent efflux pump-multidrug resistance protein 1, ATP-driven GSH transporter, BCRP, bile pigment transporter-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
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