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BRENDA support

Information on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter

for references in articles please use BRENDA:EC7.6.2.3

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IUBMB Comments

A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.

The enzyme appears in viruses and cellular organisms

Synonyms
organic anion transporting polypeptide, rlip76, mrp-1, oatp2, oatp1, abcc5, gsh transporter, hgt1p, multidrug resistance associated protein 2, mrp transporter, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
arsenic detoxification (plants), arsenic detoxification (yeast), glutathione-mediated detoxification I, glutathione-mediated detoxification II, S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links