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Literature summary for 7.6.2.3 extracted from

  • Leslie, E.; Haimeur, A.; Waalkes, M.
    Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1) Evidence that a tri-glutathione conjugate is required (2004), J. Biol. Chem., 279, 32700-32708 .
    View publication on PubMed
Search for more literature for 7.6.2.3

Inhibitors

Inhibitors Comment Organism Structure
antimonite
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00032
-
 arsenic triglutathione[side 1] at pH 7.5 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P33527
-
-
Homo sapiens Q92887
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H-69AR cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + arsenic triglutathione[side 1] the enzyme transports arsenite only in the presence of glutathione, but not L-gamma-glutamyl-L-alpha-aminobutyryl glycine or S-methyl glutathione Homo sapiens ADP + phosphate + arsenic triglutathione[side 2]
-
 ?
additional information the enzyme does not transport arsenate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ABCC1
-
 Homo sapiens
MRP1
-
 Homo sapiens
MRP2
-
 Homo sapiens
multidrug resistance protein 1
-
 Homo sapiens
multidrug resistance protein 2
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0028
-
 antimonite at pH 7.5 and 37°C Homo sapiens