Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | - |
Rattus norvegicus | |
dithioerythritol | - |
Rattus norvegicus | |
dithiothreitol | noncompetitive inhibition | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
canicular membrane | - |
Rattus norvegicus | - |
- |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + glutathione disulfide[side 1] | Rattus norvegicus | - |
ADP + phosphate + glutathione disulfide[side 2] | - |
? | |
ATP + H2O + glutathione-S-conjugate[side 1] | Rattus norvegicus | - |
ADP + phosphate + glutathione-S-conjugate[side 2] | - |
? | |
ATP + H2O + reduced glutathione[side 1] | Rattus norvegicus | - |
ADP + phosphate + reduced glutathione[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q63120 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + glutathione disulfide[side 1] | - |
Rattus norvegicus | ADP + phosphate + glutathione disulfide[side 2] | - |
? | |
ATP + H2O + glutathione-S-conjugate[side 1] | - |
Rattus norvegicus | ADP + phosphate + glutathione-S-conjugate[side 2] | - |
? | |
ATP + H2O + reduced glutathione[side 1] | - |
Rattus norvegicus | ADP + phosphate + reduced glutathione[side 2] | - |
? | |
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1] | - |
Rattus norvegicus | ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2] | - |
? | |
ATP + H2O + S-(aflatoxin B1)glutathione[side 1] | - |
Rattus norvegicus | ADP + phosphate + S-(aflatoxin B1)glutathione[side 2] | - |
? | |
ATP + H2O + S-(vincristinyl)glutathione[side 1] | - |
Rattus norvegicus | ADP + phosphate + S-(vincristinyl)glutathione[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP-driven GSH transporter | - |
Rattus norvegicus |
MRP2 | - |
Rattus norvegicus |
multidrug resistance-associated protein 2 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | MRP2-deficient rats are unable to transport reduced glutathione into bile | Rattus norvegicus |
physiological function | the enzyme contributes directly to the regulation of the cellular thiol-redox status and therefore to the protection against oxidative stress | Rattus norvegicus |