Literature summary for 7.6.2.3 extracted from

Morrow, C.; Peklak-Scott, C.; Bishwokarma, B.; Kute, T.; Smitherman, P.; Townsend, A.
Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux (2006), Mol. Pharmacol., 69, 1499-1505 .

Search for more literature for 7.6.2.3

Inhibitors

Inhibitors	Comment	Organism	Structure
MK571	i.e. 3-[[3-[2-(7-chloroquinolin-2-yl)vinyl]phenyl]-(2-dimethylcarbamoylethylsulfanyl)methylsulfanyl]propionic acid	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P33527	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + S-(mitoxantronyl)glutathione[side 1]	-	Homo sapiens	ADP + phosphate + S-(mitoxantronyl)glutathione[side 2]	-	?

Subunits

Subunits	Comment	Organism
?	x * 190000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ABCC1	-	Homo sapiens
MRP1	-	Homo sapiens
multidrug resistance-associated protein 1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	multidrug resistance protein 1 mediates resistance to mitoxantrone via glutathione-dependent drug efflux	Homo sapiens
physiological function	the enzyme can significantly influence tumor cell sensitivity to and pharmacological disposition of mitoxantrone	Homo sapiens

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Release 2023.1 (January 2023)