Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.6.2.3 extracted from

  • Peklak-Scott, C.; Townsend, A.; Morrow, C.
    Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide Contributions of glutathione, glutathione S-transferase, and MRP1 (2005), Biochemistry, 44, 4426-4433 .
    View publication on PubMed
Search for more literature for 7.6.2.3

Activating Compound

Activating Compound Comment Organism Structure
glutathione
-
 Homo sapiens
S-Methylglutathione
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0095
-
 4-(glutathione-S-yl)-quinoline-1-oxide[side 1] pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 4-(glutathione-S-yl)-quinoline-1-oxide[side 1]
-
 Homo sapiens ADP + phosphate + 4-(glutathione-S-yl)-quinoline-1-oxide[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
additional information enzyme-mediated S-(4-nitroquinoline-1-oxide)glutathione transport does not involve co-transport of glutathione Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MRP1
-
 Homo sapiens
multidrug resistance-associated protein 1
-
 Homo sapiens