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Literature summary for 7.6.2.3 extracted from

  • Huang, S.; Ye, J.; Yu, J.; Chen, L.; Zhou, L.; Wang, H.; Li, Z.; Wang, C.
    The accumulation and efflux of lead partly depend on ATP-dependent efflux pump-multidrug resistance protein 1 and glutathione in testis Sertoli cells (2014), Toxicol. Lett., 226, 277-284 .
    View publication on PubMed
Search for more literature for 7.6.2.3

Inhibitors

Inhibitors Comment Organism Structure
MK571
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Sertoli cell
-
 Mus musculus
-
testis
-
 Mus musculus
-
TM-4 cell and a cell line with lower expression of Mrp1, TM4-sh cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + S-(5-carboxyseminaphtharhodafluor-AM)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(5-carboxyseminaphtharhodafluor-AM)glutathione[side 2]
-
 ?
ATP + H2O + S-(calcein-AM)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(calcein-AM)glutathione[side 2]
-
 ?
ATP + H2O + S-(lead acetyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(lead acetyl)glutathione[side 2]
-
 ?

Subunits

Subunits Comment Organism
? x * 172000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ATP-dependent efflux pump-multidrug resistance protein 1
-
 Mus musculus
MRP1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus expression levels of mRNA and protein of the mrp1 gene in TM-4 cells are significantly induced by lead up