EC Number   |
General Information |
Reference |
|---|
   7.6.2.3 | malfunction |
MRP2-deficient rats are unable to transport reduced glutathione into bile |
747605 |
| 7.6.2.3 | metabolism |
multidrug resistance protein 1 mediates resistance to mitoxantrone via glutathione-dependent drug efflux |
748697 |
| 7.6.2.3 | metabolism |
over 90% of bismuth is passively absorbed, conjugated to glutathione, and transported into vesicles by the enzyme |
749174 |
| 7.6.2.3 | metabolism |
the enzyme transports glutathione S-conjugates of xenobiotics and endogenous substances, including herbicides and anthocyanins out of the cytosol |
749195 |
| 7.6.2.3 | physiological function |
apical multidrug resistance-associated protein 2 plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites |
747707 |
| 7.6.2.3 | physiological function |
enzyme-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum |
747938 |
| 7.6.2.3 | physiological function |
MRP1 is a high-affinity transporter of the cysteinyl leukotriene C4 and is responsible for the systemic release of this cytokine in response to an inflammatory stimulus |
747762 |
| 7.6.2.3 | physiological function |
the enzyme can significantly influence tumor cell sensitivity to and pharmacological disposition of mitoxantrone |
748697 |
| 7.6.2.3 | physiological function |
the enzyme contributes directly to the regulation of the cellular thiol-redox status and therefore to the protection against oxidative stress |
747605 |
| 7.6.2.3 | physiological function |
the enzyme is associated with multiple drug resistance of malignant tumors because of their capacity to pump drug conjugates and drug complexes across the plasma membrane into the extracellular space |
747225 |
