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Literature summary for 7.6.2.3 extracted from

  • Yokooji, T.; Murakami, T.; Ogawa, K.; Yumoto, R.; Nagai, J.; Takano, M.
    Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats (2005), J. Pharm. Pharmacol., 57, 579-585 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1] Rattus norvegicus
-
 ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q63120
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ileum
-
 Rattus norvegicus
-
intestine
-
 Rattus norvegicus
-
jejunum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
MRP2
-
 Rattus norvegicus
multidrug resistance-associated protein 2
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus suppression of enzyme activity in jejunum is observed after intravenous administration of bilirubin and co-administration of bilirubin as well as probenecid or ciclosporin down